Development Level

Tbio 8 | 11,445
Tchem 4 | 1,598

IMPC Phenotype

embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
preweaning lethality, complete... 2 | 979
short tibia 2 | 97
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal retina morphology 1 | 71
decreased circulating serum al... 1 | 82
decreased spleen weight 1 | 10
embryonic growth retardation 1 | 106
enlarged kidney 1 | 14
increased circulating alkaline... 1 | 122
increased circulating glucose ... 1 | 24
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 10 | 11,493
ovarian cancer 10 | 8,520
Cancer 7 | 2,499
atypical teratoid / rhabdoid tumor 6 | 5,112
glioblastoma 6 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
lung cancer 6 | 4,740
osteosarcoma 6 | 7,950
Melanoma 5 | 711
astrocytic glioma 5 | 2,597
subependymal giant cell astrocytoma 5 | 2,287
Breast cancer 4 | 3,578
Intellectual disability 4 | 1,016
adult high grade glioma 4 | 3,801
group 3 medulloblastoma 4 | 4,104
medulloblastoma, large-cell 4 | 6,241
Abnormal dermatoglyphic pattern 3 | 24
Abnormality of vision 3 | 40
Alopecia 3 | 115
Asymmetric growth 3 | 5
Asymmetry of the posterior cranium 3 | 20
Basal cell carcinoma 3 | 54
Basal cell nevi 3 | 23
Blepharoptosis 3 | 231
Byzanthine arch palate 3 | 194
Carcinoma, Hepatocellular 3 | 228
Cardiac Arrhythmia 3 | 103
Cardiac conduction abnormalities 3 | 78
Cell Transformation, Neoplastic 3 | 97
Cerebellar hypoplasia and atrophy 3 | 41
Conduction disorder of the heart 3 | 79
Congenital ocular coloboma (disorder) 3 | 40
Congenital pectus carinatum 3 | 52
Connective tissue cancer 3 | 10
Cranial asymmetry 3 | 5
Curly hair (finding) 3 | 14
Decreased to absent deep tendon reflexes 3 | 42
Defect of vertebral segmentation 3 | 17
Delayed bone age 3 | 136
Dental abnormalities 3 | 60
Downward slant of palpebral fissure 3 | 158
EKG abnormalities 3 | 78
Electrocardiogram abnormal 3 | 81
Electrocardiogram change 3 | 78
Electroencephalogram abnormal 3 | 101
Excess nuchal skin 3 | 30
Facial asymmetry 3 | 32
Fetal overgrowth 3 | 16
Fibrous skin tumor of tuberous sclerosis 3 | 18
Flattening of cranial vault 3 | 20
Flattening of head 3 | 20
Frequent fractures 3 | 53
Frontal bossing 3 | 157
Full lower lip 3 | 64
Generalized osteopenia 3 | 99
Generalized overgrowth 3 | 16
Genu recurvatum 3 | 12
Hemangioma 3 | 69
Hemangioma, Cavernous 3 | 20
Hemimegalencephaly 3 | 5
Horseshoe Kidney 3 | 16
Hyperreflexia 3 | 209
Hypophosphatemic Rickets 3 | 11
Hypopigmentation disorder 3 | 25
Ichthyoses 3 | 41
Increased fracture rate 3 | 53
Irregular hyperpigmentation 3 | 33
Isolated cases 3 | 72
Joint hyperflexibility 3 | 78
Juvenile Myelomonocytic Leukemia 3 | 21
Kyphoscoliosis deformity of spine 3 | 60
Leukemia, Myelomonocytic, Juvenile 3 | 20
Leukocytosis 3 | 17
Liver carcinoma 3 | 240
Lymphoma 3 | 81
Melanocytic nevus 3 | 43
Neoplasms, Experimental 3 | 40
Neoplastic Cell Transformation 3 | 89
Neuroblastoma 3 | 80
Noncancerous mole 3 | 28
Noonan syndrome 3 | 34
Osteopenia 3 | 99
Overgrowth 3 | 16
Papillary thyroid carcinoma 3 | 43
Plagiocephaly 3 | 20
Plagiocephaly, Nonsynostotic 3 | 20
Porencephaly 3 | 20
Prominent back of the head 3 | 21
Prominent lower lip 3 | 64
Prominent occiput 3 | 21
Rhabdomyosarcoma 3 | 39
Rhomboid shaped head 3 | 20
Sebaceous adenoma 3 | 26
Stomach Neoplasms 3 | 300
Strabismus 3 | 270
Telecanthus 3 | 62
Thyroid cancer 3 | 36
Tooth Abnormalities 3 | 69
Upper respiratory tract disease 3 | 15
Varying degree of multiple fractures 3 | 53

Tissue

Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678

Target Family

Enzyme 8 | 4,145
Non-IDG 3 | 12,091
Transcription Factor 1 | 1,400

WikiPathways Pathway

RalA downstream regulated gene... 12 | 12
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Ras-related C3 botulinum toxin substrate 2 RAC2 Tbio Enzyme -2.89402 669.8 273
Ras-related protein Ral-A RALA Tbio Enzyme -2.22188 169.9 225
Y-box-binding protein 3 YBX3 Tbio Transcription Factor -2.13168 143.1 204
RalA-binding protein 1 RALBP1 Tbio Non-IDG -1.99667 110.8 320
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Exocyst complex component 2 EXOC2 Tbio Non-IDG -1.73003 48.8 86