Development Level

Tchem 37 | 1,598
Tbio 24 | 11,445
Tclin 6 | 613

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal bone structure 2 | 187
abnormal cornea morphology 2 | 31
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal pericardium morpholog... 1 | 26
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
abnormal startle reflex 1 | 15
anophthalmia 1 | 33
decreased bone mineral content 1 | 151
decreased circulating amylase ... 1 | 28
decreased circulating glucose ... 1 | 126
decreased circulating sodium l... 1 | 22
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased leukocyte cell numbe... 1 | 47
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
prenatal lethality 1 | 28
short tibia 1 | 97

Disease

Carcinoma 53 | 11,493
Cancer 52 | 2,499
osteosarcoma 44 | 7,950
ovarian cancer 44 | 8,520
glioblastoma 37 | 5,792
lung cancer 34 | 4,740
psoriasis 34 | 6,694
medulloblastoma, large-cell 29 | 6,241
Breast cancer 28 | 3,578
ependymoma 27 | 4,679
atypical teratoid / rhabdoid tumor 26 | 5,112
Breast Neoplasms 24 | 445
Mammary Neoplasms 23 | 425
group 3 medulloblastoma 21 | 4,104
invasive ductal carcinoma 21 | 2,951
Kidney cancer 19 | 2,613
Vascular disease 19 | 319
breast carcinoma 19 | 1,638
Lung Neoplasms 18 | 232
adult high grade glioma 18 | 3,801
diabetes mellitus 18 | 1,728
ductal carcinoma in situ 18 | 1,745
lung adenocarcinoma 18 | 2,716
oligodendroglioma 18 | 2,850
Stomach Neoplasms 17 | 300
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
Astrocytoma, Pilocytic 16 | 3,081
adrenocortical carcinoma 16 | 1,428
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
lung carcinoma 16 | 2,843
Carcinoma, Squamous Cell 15 | 110
Neoplasm Metastasis 15 | 168
Schizophrenia 15 | 1,160
Squamous cell carcinoma 15 | 129
malignant mesothelioma 15 | 3,232
non-small cell lung cancer 15 | 2,890
pancreatic cancer 15 | 2,398
Prostatic Neoplasms 14 | 495
Renal Cell Carcinoma 14 | 214
astrocytic glioma 14 | 2,597
primitive neuroectodermal tumor 14 | 3,035
subependymal giant cell astrocytoma 14 | 2,287
tuberculosis 14 | 2,010
Adenocarcinoma 13 | 122
Cell Transformation, Neoplastic 13 | 97
Colonic Neoplasms 13 | 142
Ovarian Neoplasms 13 | 102
pituitary cancer 13 | 1,972
Arthritis 12 | 290
Neoplastic Cell Transformation 12 | 89
Pick disease 12 | 1,894
juvenile dermatomyositis 12 | 1,187
ovarian neoplasm 12 | 99
Carcinoma, Hepatocellular 11 | 228
Depressive disorder 11 | 409
Liver carcinoma 11 | 240
group 4 medulloblastoma 11 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Adenoma 10 | 167
Autosomal recessive predisposition 10 | 1,442
Brain Ischemia 10 | 110
Colorectal Neoplasms 10 | 243
Dull intelligence 10 | 645
Intellectual disability 10 | 1,016
Kidney disease 10 | 430
Low intelligence 10 | 645
Mammary Neoplasms, Experimental 10 | 154
Melanoma 10 | 711
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Neoplasm Invasiveness 10 | 161
Poor school performance 10 | 645
Rheumatoid arthritis 10 | 1,191
Seizures 10 | 596
interstitial cystitis 10 | 2,312
nasopharyngeal carcinoma 10 | 1,058
pediatric high grade glioma 10 | 1,064
Acquired scoliosis 9 | 281
Animal Mammary Neoplasms 9 | 136
Curvature of spine 9 | 282
Disease Models, Animal 9 | 155
Liver Neoplasms, Experimental 9 | 59
Lung disease 9 | 142
Mammary Neoplasms, Animal 9 | 136
Short stature 9 | 531
Skin cancer 9 | 469
astrocytoma 9 | 1,146
cystic fibrosis 9 | 1,696
ulcerative colitis 9 | 1,819
Byzanthine arch palate 8 | 194
Endometrial cancer 8 | 311
Epilepsy 8 | 792
Frontal bossing 8 | 157
Hypoplastic mandible condyle 8 | 275
Immune system cancer 8 | 140
Mandibular hypoplasia 8 | 275
Micrognathism 8 | 275
Muscle hypotonia 8 | 571
Neuroblastoma 8 | 80

Tissue

Blood and immune system 66 | 16,909
Endocrine System 66 | 18,159
Nervous System 66 | 16,725
Respiratory system 66 | 16,393
Digestive Tract 65 | 17,369
Female tissues 65 | 17,400
Liver and Pancreas 65 | 16,750
Male tissues 65 | 17,142
Skin and soft tissues 65 | 17,230
Urinary Tract 65 | 16,678
Cardiovascular System 62 | 15,192

Target Family

Non-IDG 28 | 12,091
Kinase 21 | 634
Enzyme 10 | 4,145
Transcription Factor 8 | 1,400

WikiPathways Pathway

Rac1/Pak1/p38/MMP-2 pathway 67 | 67
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Angiopoietin-related protein 1 ANGPTL1 Tbio Non-IDG -1.27029 19.3 252
Fibronectin FN1 Tchem Non-IDG -3.09873 1208.8 1583
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Retinoschisin RS1 Tbio Non-IDG -2.10828 131.3 39
Nitric oxide synthase, inducible NOS2 Tchem Enzyme -3.35134 2277.5 752
Focal adhesion kinase 1 PTK2 Tchem Kinase -3.06733 1038.3 2013
Caspase-9 CASP9 Tchem Enzyme -3.44725 2332.0 1313