Development Level

Tchem 26 | 1,388
Tbio 23 | 11,651
Tclin 6 | 612

IMPC Phenotype

preweaning lethality, complete... 7 | 979
increased circulating alkaline... 3 | 122
increased neutrophil cell numb... 3 | 46
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal gait 2 | 69
decreased body weight 2 | 161
decreased circulating LDL chol... 2 | 38
decreased circulating creatini... 2 | 39
embryonic lethality prior to t... 2 | 278
increased circulating LDL chol... 2 | 13
increased spleen weight 2 | 10
increased total body fat amoun... 2 | 134
short tibia 2 | 97
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal femur morphology 1 | 14
abnormal glucose homeostasis 1 | 4
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal skin condition 1 | 6
decreased blood urea nitrogen ... 1 | 51
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to o... 1 | 239
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased heart left ventricle... 1 | 4
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased thermal nociceptive ... 1 | 9
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Cancer 46 | 2,499
Carcinoma 44 | 11,493
ovarian cancer 35 | 8,520
osteosarcoma 32 | 7,950
glioblastoma 28 | 5,792
lung cancer 28 | 4,740
psoriasis 23 | 6,694
Arthritis 21 | 290
diabetes mellitus 20 | 1,728
atypical teratoid / rhabdoid tumor 18 | 5,112
medulloblastoma, large-cell 18 | 6,241
tuberculosis 17 | 2,010
Rheumatoid arthritis 16 | 1,191
malignant mesothelioma 16 | 3,232
Breast cancer 15 | 3,578
Kidney cancer 15 | 2,613
Schizophrenia 15 | 1,160
adult high grade glioma 15 | 3,801
ependymoma 15 | 4,679
non-small cell lung cancer 15 | 2,890
subependymal giant cell astrocytoma 14 | 2,287
Osteoporosis 13 | 363
lung carcinoma 13 | 2,843
ulcerative colitis 13 | 1,819
Osteopetrosis 12 | 43
Pick disease 12 | 1,894
Vascular disease 12 | 319
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
pancreatic cancer 12 | 2,398
pituitary cancer 12 | 1,972
Astrocytoma, Pilocytic 11 | 3,081
Autosomal recessive predisposition 11 | 1,442
Obesity 11 | 678
oligodendroglioma 11 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Asthma 10 | 385
Kidney disease 10 | 430
Multiple myeloma 10 | 1,332
cystic fibrosis 10 | 1,696
group 4 medulloblastoma 10 | 1,855
interstitial cystitis 10 | 2,312
Alzheimer's disease 9 | 658
Breast Neoplasms 9 | 445
Hyperglycemia 9 | 137
Lung disease 9 | 142
Mammary Neoplasms 9 | 425
Short stature 9 | 531
group 3 medulloblastoma 9 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
lung adenocarcinoma 9 | 2,716
periodontitis 9 | 293
Brain Ischemia 8 | 110
Carcinoma, Hepatocellular 8 | 228
Cell Transformation, Neoplastic 8 | 97
Cholestasis, Extrahepatic 8 | 25
Inflammatory bowel disease 8 | 151
Liver carcinoma 8 | 240
Lung Neoplasms 8 | 232
Multiple Sclerosis 8 | 540
Parkinson's disease 8 | 392
astrocytoma 8 | 1,146
colon cancer 8 | 1,478
invasive ductal carcinoma 8 | 2,951
primary Sjogren syndrome 8 | 735
primitive neuroectodermal tumor 8 | 3,035
Epilepsy 7 | 792
Frontal bossing 7 | 157
Heart disease 7 | 306
Hypertension 7 | 396
Hypertensive disease 7 | 292
Intellectual disability 7 | 1,016
Neoplastic Cell Transformation 7 | 89
Toxic encephalopathy 7 | 141
Waldenstrons macroglobulinemia 7 | 765
dermatomyositis 7 | 966
gastric carcinoma 7 | 807
juvenile dermatomyositis 7 | 1,187
Chronic Lymphocytic Leukemia 6 | 262
Cognitive delay 6 | 608
Colonic Neoplasms 6 | 142
Depressive disorder 6 | 409
Disease Models, Animal 6 | 155
Global developmental delay 6 | 608
Hyperalgesia 6 | 83
Immunologic Deficiency Syndromes 6 | 113
Lytic lesion 6 | 32
Melanoma 6 | 711
Mental and motor retardation 6 | 608
Neoplasm Invasiveness 6 | 161
Neoplasm Metastasis 6 | 168
Recurrent respiratory infections 6 | 141
Renal Cell Carcinoma 6 | 214
Reperfusion Injury 6 | 86
Seizures 6 | 596
Stomach Neoplasms 6 | 300
acute myeloid leukemia 6 | 783
astrocytic glioma 6 | 2,597
nasopharyngeal carcinoma 6 | 1,058
sonic hedgehog group medulloblastoma 6 | 467

Tissue

Digestive Tract 55 | 17,369
Endocrine System 55 | 18,159
Female tissues 55 | 17,400
Liver and Pancreas 55 | 16,750
Male tissues 55 | 17,142
Respiratory system 55 | 16,393
Skin and soft tissues 55 | 17,230
Urinary Tract 55 | 16,678
Blood and immune system 54 | 16,909
Cardiovascular System 54 | 15,192
Nervous System 54 | 16,725

Target Family

Kinase 21 | 634
Non-IDG 14 | 12,091
Transcription Factor 10 | 1,400
Enzyme 9 | 4,145
GPCR 1 | 408

WikiPathways Pathway

RANKL/RANK (Receptor activator... 55 | 55
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Sequestosome-1 SQSTM1 Tbio Non-IDG -2.78728 635.1 766
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.74221 511.1 403
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Dual specificity mitogen-activated protein kinase kinase 6 MAP2K6 Tchem Kinase -2.01763 74.4 636
Nuclear factor NF-kappa-B p100 subunit NFKB2 Tchem Transcription Factor -2.29577 191.3 637
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.46817 32.4 765
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 Tbio Enzyme -1.90517 75.2 151
Proto-oncogene c-Fos FOS Tbio Transcription Factor -4.14231 13598.8 1058