Development Level

Tbio 57 | 11,445
Tchem 12 | 1,598
Tclin 10 | 613
Tdark 5 | 6,588

IMPC Phenotype

preweaning lethality, complete... 15 | 979
embryonic lethality prior to o... 10 | 239
embryonic lethality prior to t... 5 | 278
abnormal behavior 3 | 298
abnormal embryo size 3 | 220
increased mean corpuscular vol... 3 | 92
decreased bone mineral content 2 | 151
decreased circulating sodium l... 2 | 22
decreased mean corpuscular hem... 2 | 31
embryonic growth retardation 2 | 106
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased mean corpuscular hem... 2 | 96
prenatal lethality prior to he... 2 | 87
preweaning lethality, incomple... 2 | 499
abnormal clavicle morphology 1 | 6
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal embryonic autopod pla... 1 | 2
abnormal epididymis morphology 1 | 42
abnormal facial morphology 1 | 17
abnormal hair growth 1 | 10
abnormal placenta morphology 1 | 5
abnormal posture 1 | 2
abnormal rib morphology 1 | 10
abnormal stomach morphology 1 | 10
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
enlarged lymph nodes 1 | 37
enlarged urinary bladder 1 | 8
female infertility 1 | 60
increased T cell number 1 | 6
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased erythrocyte cell num... 1 | 39
increased or absent threshold ... 1 | 101
increased vertical activity 1 | 24
long tibia 1 | 25
male infertility 1 | 123
prenatal lethality 1 | 28
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
thin ventricular wall 1 | 24
tremors 1 | 39
unresponsive to tactile stimul... 1 | 8

Disease

ovarian cancer 46 | 8,520
lung cancer 35 | 4,740
osteosarcoma 35 | 7,950
Carcinoma 32 | 11,493
medulloblastoma, large-cell 32 | 6,241
group 3 medulloblastoma 31 | 4,104
psoriasis 26 | 6,694
glioblastoma 23 | 5,792
non-small cell lung cancer 20 | 2,890
primitive neuroectodermal tumor 20 | 3,035
atypical teratoid / rhabdoid tumor 19 | 5,112
malignant mesothelioma 18 | 3,232
Autosomal recessive predisposition 16 | 1,442
ependymoma 16 | 4,679
Breast cancer 15 | 3,578
Cancer 15 | 2,499
tuberculosis 15 | 2,010
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
invasive ductal carcinoma 13 | 2,951
Kidney cancer 12 | 2,613
Multiple myeloma 12 | 1,332
Colorectal Neoplasms 11 | 243
oligodendroglioma 11 | 2,850
interstitial cystitis 10 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
pancreatic cancer 10 | 2,398
pediatric high grade glioma 10 | 1,064
adult high grade glioma 9 | 3,801
lung adenocarcinoma 9 | 2,716
Astrocytoma, Pilocytic 8 | 3,081
Endometriosis 8 | 540
Pick disease 8 | 1,894
adrenocortical carcinoma 8 | 1,428
breast carcinoma 8 | 1,638
colon cancer 8 | 1,478
diabetes mellitus 8 | 1,728
ductal carcinoma in situ 8 | 1,745
non primary Sjogren syndrome sicca 8 | 891
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
ulcerative colitis 8 | 1,819
Carcinoma, Hepatocellular 7 | 228
Cognitive delay 7 | 608
Global developmental delay 7 | 608
Intellectual disability 7 | 1,016
Liver carcinoma 7 | 240
Mental and motor retardation 7 | 608
Waldenstrons macroglobulinemia 7 | 765
astrocytoma 7 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
Adenocarcinoma of lung 6 | 142
Adenocarcinoma of pancreas 6 | 14
Cerebellar Ataxia 6 | 304
Disease Models, Animal 6 | 155
Dull intelligence 6 | 645
Epilepsy 6 | 792
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Metastatic Breast Carcinoma 6 | 21
Poor school performance 6 | 645
Seizures 6 | 596
Stomach Neoplasms 6 | 300
Treacher Collins syndrome 6 | 27
astrocytic glioma 6 | 2,597
lung carcinoma 6 | 2,843
nasopharyngeal carcinoma 6 | 1,058
pituitary cancer 6 | 1,972
Acute lymphoid leukemia 5 | 25
Atopic dermatitis 5 | 952
Cleft Palate 5 | 271
Downward slant of palpebral fissure 5 | 158
Hereditary spherocytosis type 5 5 | 12
Hypoplastic mandible condyle 5 | 275
Malignant tumor of ovary 5 | 25
Mandibular hypoplasia 5 | 275
Micrognathism 5 | 275
Progressive disorder 5 | 142
acute myeloid leukemia 5 | 783
cystic fibrosis 5 | 1,696
gastric carcinoma 5 | 807
primary Sjogren syndrome 5 | 735
primary pancreatic ductal adenocarcinoma 5 | 1,109
subependymal giant cell astrocytoma 5 | 2,287
Anemia 4 | 365
Cerebral atrophy 4 | 178
Colonic Neoplasms 4 | 142
Congenital small ears 4 | 48
Deafness 4 | 198
Dysarthria 4 | 192
Highly variable clinical phenotype 4 | 150
Highly variable phenotype and severity 4 | 150
Highly variable phenotype, even within families 4 | 150
Muscle hypotonia 4 | 571
Myopia 4 | 176
Phenotypic variability 4 | 150
Short stature 4 | 531
Uranostaphyloschisis 4 | 167
cutaneous lupus erythematosus 4 | 1,057
hepatocellular carcinoma 4 | 547
pancreatic carcinoma 4 | 562

Tissue

Blood and immune system 83 | 16,909
Digestive Tract 83 | 17,369
Endocrine System 83 | 18,159
Female tissues 83 | 17,400
Liver and Pancreas 83 | 16,750
Male tissues 83 | 17,142
Nervous System 83 | 16,725
Respiratory system 83 | 16,393
Skin and soft tissues 83 | 17,230
Urinary Tract 83 | 16,678
Cardiovascular System 81 | 15,192

Target Family

Enzyme 68 | 4,145
Kinase 14 | 634
Non-IDG 2 | 12,091

WikiPathways Pathway

Pyrimidine metabolism 84 | 84
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoside diphosphate kinase B NME1-NME2 Tbio Kinase -2.85003 1033.0 85
Nucleoside diphosphate kinase A NME1 Tbio Kinase -2.99077 863.1 945
5'(3')-deoxyribonucleotidase, mitochondrial NT5M Tchem Enzyme -2.92598 803.3 44
Thymidylate synthase TYMS Tclin Enzyme -2.93426 732.0 733
Thymidine phosphorylase TYMP Tclin Enzyme -2.83170 677.8 514
Ribonucleoside-diphosphate reductase large subunit RRM1 Tclin Enzyme -2.84926 663.0 399
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1 Tchem Enzyme -2.74480 552.8 275
Ectonucleoside triphosphate diphosphohydrolase 1 ENTPD1 Tchem Enzyme -2.68249 518.8 505
Cytidine deaminase CDA Tchem Enzyme -2.76345 515.2 231
Deoxycytidine kinase DCK Tchem Kinase -2.63558 455.4 434