Development Level

Tbio 17 | 11,445
Tclin 16 | 613
Tchem 12 | 1,598

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal eye size 1 | 7
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal vibrissa morphology 1 | 25
decreased basophil cell number 1 | 16
decreased body weight 1 | 161
decreased circulating alanine ... 1 | 47
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
increased anti-nuclear antigen... 1 | 19
increased circulating sodium l... 1 | 71
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
preweaning lethality, incomple... 1 | 499

Disease

Cancer 30 | 2,499
ovarian cancer 30 | 8,520
Carcinoma 29 | 11,493
lung cancer 29 | 4,740
osteosarcoma 27 | 7,950
glioblastoma 26 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
lung carcinoma 22 | 2,843
non-small cell lung cancer 22 | 2,890
malignant mesothelioma 21 | 3,232
medulloblastoma, large-cell 21 | 6,241
ependymoma 20 | 4,679
psoriasis 20 | 6,694
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
pancreatic cancer 19 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,955
invasive ductal carcinoma 18 | 2,951
lung adenocarcinoma 18 | 2,716
Astrocytoma, Pilocytic 17 | 3,081
cystic fibrosis 17 | 1,696
ulcerative colitis 17 | 1,819
Liver Cirrhosis, Experimental 16 | 769
adult high grade glioma 16 | 3,801
colon cancer 15 | 1,478
group 3 medulloblastoma 15 | 4,104
atypical teratoid / rhabdoid tumor 14 | 5,112
interstitial cystitis 14 | 2,312
Breast cancer 13 | 3,578
Hypertension 13 | 396
pituitary cancer 13 | 1,972
Endometriosis 12 | 540
breast carcinoma 12 | 1,638
ductal carcinoma in situ 12 | 1,745
oligodendroglioma 12 | 2,850
Schizophrenia 11 | 1,160
gastric carcinoma 11 | 807
primitive neuroectodermal tumor 11 | 3,035
subependymal giant cell astrocytoma 11 | 2,287
tuberculosis 11 | 2,010
Asthma 10 | 385
Duchenne muscular dystrophy 10 | 601
Kidney disease 10 | 430
diabetes mellitus 10 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Atopic dermatitis 9 | 952
Osteoarthritis 9 | 184
Polycystic ovary syndrome 9 | 360
Prostatic Neoplasms 9 | 495
Rheumatoid arthritis 9 | 1,191
adrenocortical carcinoma 9 | 1,428
astrocytic glioma 9 | 2,597
Arthritis 8 | 290
Heart failure 8 | 162
Obesity 8 | 678
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510
juvenile dermatomyositis 8 | 1,187
Animal Mammary Neoplasms 7 | 136
Autosomal recessive predisposition 7 | 1,442
Bipolar Disorder 7 | 666
Heart disease 7 | 306
Hypertensive disease 7 | 292
Mammary Neoplasms, Animal 7 | 136
Pain 7 | 103
active ulcerative colitis 7 | 764
adrenocortical adenoma 7 | 131
astrocytoma 7 | 1,146
esophageal adenocarcinoma 7 | 737
group 4 medulloblastoma 7 | 1,855
Becker muscular dystrophy 6 | 191
Diabetes Mellitus, Experimental 6 | 108
Diabetes Mellitus, Non-Insulin-Dependent 6 | 145
Diabetes Mellitus, Type 2 6 | 142
Hyperglycemia 6 | 137
Inflammation 6 | 120
Kidney cancer 6 | 2,613
Mammary Neoplasms, Experimental 6 | 154
Mood Disorders 6 | 184
Patent ductus arteriosus 6 | 90
Pick disease 6 | 1,894
active Crohn's disease 6 | 922
aldosterone-producing adenoma 6 | 665
fibroadenoma 6 | 559
limb girdle muscular dystrophy 2A 6 | 213
medulloblastoma 6 | 720
primary pancreatic ductal adenocarcinoma 6 | 1,109
Adenoma 5 | 167
Allergic rhinitis 5 | 94
Arthritis, Rheumatoid 5 | 174
Atherosclerosis 5 | 291
Carcinoma, Hepatocellular 5 | 228
Cerebrovascular disease 5 | 238
Coronary artery disease 5 | 268
Liver carcinoma 5 | 240
Major Depressive Disorder 5 | 301
acute quadriplegic myopathy 5 | 1,158
dermatomyositis 5 | 966
head and neck cancer 5 | 271
nasopharyngeal carcinoma 5 | 1,058
nephrosclerosis 5 | 333
pediatric high grade glioma 5 | 1,064

Tissue

Digestive Tract 45 | 17,369
Endocrine System 45 | 18,159
Female tissues 45 | 17,400
Male tissues 45 | 17,142
Skin and soft tissues 45 | 17,230
Urinary Tract 45 | 16,678
Blood and immune system 44 | 16,909
Liver and Pancreas 44 | 16,750
Respiratory system 44 | 16,393
Nervous System 43 | 16,725
Cardiovascular System 42 | 15,192

Target Family

Enzyme 17 | 4,145
Non-IDG 14 | 12,091
GPCR 10 | 408
Transcription Factor 2 | 1,400
Nuclear Receptor 1 | 48
Transporter 1 | 473

WikiPathways Pathway

Prostaglandin Synthesis and Re... 45 | 45
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
15-hydroxyprostaglandin dehydrogenase [NAD(+)] HPGD Tchem Enzyme -2.26841 191.0 354
Multidrug resistance-associated protein 4 ABCC4 Tchem Transporter -2.56001 341.6 352
Prostaglandin G/H synthase 1 PTGS1 Tclin Enzyme -3.23035 1641.3 479
Prostaglandin G/H synthase 2 PTGS2 Tclin Enzyme -4.06834 12504.5 731
Protein S100-A10 S100A10 Tbio Non-IDG -2.26116 191.4 354
Thromboxane A2 receptor TBXA2R Tclin GPCR -2.17674 123.4 112
Prostaglandin F2 receptor negative regulator PTGFRN Tbio Non-IDG -1.42165 26.8 105
Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 Tchem Enzyme -3.04846 1171.6 189
Annexin A3 ANXA3 Tbio Non-IDG -2.01462 104.6 354
Prostaglandin E synthase PTGES Tchem Enzyme -3.05403 1164.2 151