Development Level

Tchem 35 | 1,598
Tbio 28 | 11,445
Tclin 13 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 5 | 499
abnormal gait 2 | 69
decreased body weight 2 | 161
decreased circulating creatini... 2 | 39
enlarged lymph nodes 2 | 37
increased mean corpuscular hem... 2 | 96
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating sodium l... 1 | 22
decreased heart left ventricle... 1 | 28
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
edema 1 | 59
enlarged spleen 1 | 41
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased circulating triglyce... 1 | 42
increased heart left ventricle... 1 | 4
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased neutrophil cell numb... 1 | 46
increased thermal nociceptive ... 1 | 9
premature death 1 | 5
short tibia 1 | 97
thin ventricular wall 1 | 24

Disease

Cancer 65 | 2,499
Carcinoma 59 | 11,493
ovarian cancer 53 | 8,520
osteosarcoma 46 | 7,950
glioblastoma 41 | 5,792
lung cancer 37 | 4,740
atypical teratoid / rhabdoid tumor 34 | 5,112
medulloblastoma, large-cell 31 | 6,241
psoriasis 30 | 6,694
Breast cancer 28 | 3,578
ependymoma 25 | 4,679
Kidney cancer 24 | 2,613
diabetes mellitus 24 | 1,728
Schizophrenia 23 | 1,160
Vascular disease 22 | 319
adult high grade glioma 21 | 3,801
invasive ductal carcinoma 21 | 2,951
subependymal giant cell astrocytoma 20 | 2,287
Astrocytoma, Pilocytic 19 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
non-small cell lung cancer 19 | 2,890
Arthritis 18 | 290
group 3 medulloblastoma 18 | 4,104
group 4 medulloblastoma 18 | 1,855
primitive neuroectodermal tumor 18 | 3,035
Rheumatoid arthritis 17 | 1,191
breast carcinoma 17 | 1,638
lung carcinoma 17 | 2,843
tuberculosis 17 | 2,010
Breast Neoplasms 16 | 445
Liver Cirrhosis, Experimental 16 | 769
Mammary Neoplasms 16 | 425
Multiple myeloma 16 | 1,332
Stomach Neoplasms 16 | 300
lung adenocarcinoma 16 | 2,716
malignant mesothelioma 16 | 3,232
oligodendroglioma 16 | 2,850
pancreatic cancer 16 | 2,398
Carcinoma, Hepatocellular 15 | 228
Liver carcinoma 15 | 240
Obesity 15 | 678
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
pituitary cancer 15 | 1,972
Alzheimer's disease 14 | 658
Lung Neoplasms 14 | 232
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
Cell Transformation, Neoplastic 13 | 97
Neoplasm Metastasis 13 | 168
astrocytic glioma 13 | 2,597
astrocytoma 13 | 1,146
ulcerative colitis 13 | 1,819
Heart disease 12 | 306
Hypertension 12 | 396
Orbital separation excessive 12 | 244
Pick disease 12 | 1,894
juvenile dermatomyositis 12 | 1,187
Brain Ischemia 11 | 110
Carcinoma, Squamous Cell 11 | 110
Hyperglycemia 11 | 137
Kidney disease 11 | 430
Multiple Sclerosis 11 | 540
Neoplastic Cell Transformation 11 | 89
Parkinson's disease 11 | 392
Renal Cell Carcinoma 11 | 214
Squamous cell carcinoma 11 | 129
ductal carcinoma in situ 11 | 1,745
interstitial cystitis 11 | 2,312
Acquired scoliosis 10 | 281
Blepharoptosis 10 | 231
Byzanthine arch palate 10 | 194
Cognitive delay 10 | 608
Concave bridge of nose 10 | 195
Curvature of spine 10 | 282
Depressed nasal bridge 10 | 195
Depressed nasal root/bridge 10 | 195
Downward slant of palpebral fissure 10 | 158
Frontal bossing 10 | 157
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
Pectus excavatum 10 | 100
Precancerous Conditions 10 | 80
Prostatic Neoplasms 10 | 495
Short stature 10 | 531
dermatomyositis 10 | 966
medulloblastoma 10 | 720
primary pancreatic ductal adenocarcinoma 10 | 1,109
Asthma 9 | 385
Depressive disorder 9 | 409
Disease Models, Animal 9 | 155
Hypoplastic mandible condyle 9 | 275
Inflammatory bowel disease 9 | 151
Intellectual disability 9 | 1,016
Lung disease 9 | 142
Mammary Neoplasms, Experimental 9 | 154
Mandibular hypoplasia 9 | 275
Micrognathism 9 | 275
Neoplasm Invasiveness 9 | 161
Reperfusion Injury 9 | 86
acute quadriplegic myopathy 9 | 1,158
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962

Tissue

Digestive Tract 76 | 17,369
Endocrine System 76 | 18,159
Female tissues 76 | 17,400
Liver and Pancreas 76 | 16,750
Male tissues 76 | 17,142
Skin and soft tissues 76 | 17,230
Urinary Tract 76 | 16,678
Blood and immune system 75 | 16,909
Cardiovascular System 75 | 15,192
Nervous System 75 | 16,725
Respiratory system 75 | 16,393

Target Family

Kinase 27 | 634
Non-IDG 23 | 12,091
Enzyme 14 | 4,145
Transcription Factor 12 | 1,400

WikiPathways Pathway

Prolactin Signaling Pathway 76 | 76
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
E3 SUMO-protein ligase PIAS3 PIAS3 Tbio Transcription Factor -1.74449 53.4 174
Nitric oxide synthase, inducible NOS2 Tchem Enzyme -3.35134 2277.5 752
Peptidyl-prolyl cis-trans isomerase A PPIA Tclin Enzyme -2.97822 870.7 436
Serine/threonine-protein kinase Nek3 NEK3 Tchem Kinase -0.96532 8.63 190
GRB2-associated-binding protein 2 GAB2 Tbio Non-IDG -2.08460 139.8 494
14-3-3 protein gamma YWHAG Tbio Non-IDG -1.87443 78.9 387
Focal adhesion kinase 1 PTK2 Tchem Kinase -3.06733 1038.3 2013
ETS domain-containing protein Elk-1 ELK1 Tbio Transcription Factor -0.51976 3.02 941