Development Level

Tbio 15 | 11,445
Tchem 12 | 1,598
Tclin 5 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
decreased mean corpuscular hem... 2 | 50
decreased total body fat amoun... 2 | 207
increased lean body mass 2 | 172
abnormal behavioral response t... 1 | 66
abnormal femur morphology 1 | 14
abnormal snout morphology 1 | 23
abnormal tooth morphology 1 | 24
decreased circulating choleste... 1 | 93
decreased circulating creatine... 1 | 4
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased fasted circulating g... 1 | 65
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased vertical activity 1 | 208
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
increased circulating bilirubi... 1 | 16
increased circulating creatine... 1 | 5
increased circulating creatini... 1 | 38
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased kidney weight 1 | 6
increased mean corpuscular vol... 1 | 92
male infertility 1 | 123
persistence of hyaloid vascula... 1 | 33
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 31 | 11,493
Cancer 23 | 2,499
ovarian cancer 16 | 8,520
psoriasis 16 | 6,694
lung cancer 15 | 4,740
osteosarcoma 15 | 7,950
medulloblastoma, large-cell 13 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
atypical teratoid / rhabdoid tumor 12 | 5,112
glioblastoma 11 | 5,792
Bilirubin metabolic disorder 10 | 41
Liver disease 10 | 237
Prostatic Neoplasms 10 | 495
Breast Neoplasms 9 | 445
Chemical and Drug Induced Liver Injury 9 | 195
Kidney cancer 9 | 2,613
Mammary Neoplasms 9 | 425
Rheumatoid arthritis 9 | 1,191
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
lung adenocarcinoma 9 | 2,716
malignant mesothelioma 9 | 3,232
ulcerative colitis 9 | 1,819
Cholestasis 8 | 155
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
Epilepsy 7 | 792
adult high grade glioma 7 | 3,801
diabetes mellitus 7 | 1,728
interstitial cystitis 7 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
Adverse reaction to drug 6 | 61
Colorectal Neoplasms 6 | 243
Drug-Related Side Effects and Adverse Reactions 6 | 62
Schizophrenia 6 | 1,160
ependymoma 6 | 4,679
lung carcinoma 6 | 2,843
tuberculosis 6 | 2,010
Autosomal recessive predisposition 5 | 1,442
Neutropenia 5 | 72
Obesity 5 | 678
Sickle Cell Anemia 5 | 53
astrocytic glioma 5 | 2,597
group 4 medulloblastoma 5 | 1,855
non primary Sjogren syndrome sicca 5 | 891
pancreatic cancer 5 | 2,398
Acute kidney injury 4 | 70
Anemia 4 | 365
Arthritis, Rheumatoid 4 | 174
Breast cancer 4 | 3,578
Diarrhea 4 | 253
Liver Cirrhosis, Experimental 4 | 769
Major Depressive Disorder 4 | 301
Malaria 4 | 160
Neonatal Jaundice 4 | 30
Neoplasm Metastasis 4 | 168
Unipolar Depression 4 | 250
Vascular disease 4 | 319
active Crohn's disease 4 | 922
aldosterone-producing adenoma 4 | 665
cystic fibrosis 4 | 1,696
esophageal adenocarcinoma 4 | 737
invasive ductal carcinoma 4 | 2,951
non-small cell lung cancer 4 | 2,890
pituitary cancer 4 | 1,972
Adenocarcinoma 3 | 122
Astrocytoma, Pilocytic 3 | 3,081
Atrial Fibrillation 3 | 124
Chronic Lymphocytic Leukemia 3 | 262
Contact Dermatitis 3 | 81
Crohn's disease 3 | 321
Depressive disorder 3 | 409
Dermatitis, Contact 3 | 71
Endometriosis 3 | 540
HIV Infections 3 | 102
Human immunodeficiency virus infection 3 | 6
Icterus 3 | 82
Multiple myeloma 3 | 1,332
Nervous System Diseases 3 | 53
Pericholangitis 3 | 8
Pick disease 3 | 1,894
Waldenstrons macroglobulinemia 3 | 765
acute quadriplegic myopathy 3 | 1,158
adrenocortical carcinoma 3 | 1,428
astrocytoma 3 | 1,146
cutaneous lupus erythematosus 3 | 1,057
gastric carcinoma 3 | 807
group 3 medulloblastoma 3 | 4,104
medulloblastoma 3 | 720
nervous system disorder 3 | 53
non-small cell lung carcinoma 3 | 317
oligodendroglioma 3 | 2,850
primitive neuroectodermal tumor 3 | 3,035
Coronary artery disease 2 | 268
Heart disease 2 | 306
Hepatomegaly 2 | 285
Hypertension 2 | 396
Inflammatory bowel disease 2 | 151
Kidney disease 2 | 430
Psychotic Disorders 2 | 151
active ulcerative colitis 2 | 764
pediatric high grade glioma 2 | 1,064

Tissue

Liver and Pancreas 33 | 16,750
Digestive Tract 31 | 17,369
Skin and soft tissues 31 | 17,230
Male tissues 30 | 17,142
Urinary Tract 30 | 16,678
Female tissues 29 | 17,400
Endocrine System 28 | 18,159
Respiratory system 27 | 16,393
Blood and immune system 26 | 16,909
Nervous System 24 | 16,725
Cardiovascular System 18 | 15,192

Target Family

Enzyme 11 | 4,145
Non-IDG 11 | 12,091
Transporter 5 | 473
Epigenetic 2 | 242
Nuclear Receptor 2 | 48
Kinase 1 | 634
Transcription Factor 1 | 1,400

WikiPathways Pathway

Pregnane X Receptor pathway 33 | 33
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
Canalicular multispecific organic anion transporter 2 ABCC3 Tbio Transporter -2.46032 287.4 214
Multidrug resistance-associated protein 4 ABCC4 Tchem Transporter -2.56001 341.6 352
Nuclear receptor-interacting protein 1 NRIP1 Tbio Non-IDG -2.21323 183.8 155
Cytochrome P450 2C19 CYP2C19 Tchem Non-IDG -3.22652 1740.4 154
Nuclear receptor subfamily 1 group I member 2 NR1I2 Tchem Nuclear Receptor -3.15331 1582.6 305
UDP-glucuronosyltransferase 1-3 UGT1A3 Tbio Enzyme -1.83933 63.3 13
UDP-glucuronosyltransferase 1-1 UGT1A1 Tchem Enzyme -2.95436 932.5 146
Bile salt sulfotransferase SULT2A1 Tbio Enzyme -3.24754 1727.7 308
Multidrug resistance protein 1 ABCB1 Tchem Transporter -3.61827 4039.4 875