Development Level

Tbio 19 | 11,651
Tchem 9 | 1,388

IMPC Phenotype

preweaning lethality, complete... 4 | 979
decreased mean corpuscular vol... 3 | 79
decreased red blood cell distr... 2 | 41
embryonic lethality prior to t... 2 | 278
hyperactivity 2 | 148
increased hemoglobin content 2 | 45
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased mean corpuscular hem... 2 | 36
increased mean corpuscular vol... 2 | 92
abnormal QT variability 1 | 10
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
cataract 1 | 92
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased leukocyte cell numbe... 1 | 47
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
vertebral fusion 1 | 23

Disease

Carcinoma 19 | 11,493
ovarian cancer 18 | 8,520
Cancer 17 | 2,499
psoriasis 14 | 6,694
osteosarcoma 13 | 7,950
diabetes mellitus 12 | 1,728
lung cancer 12 | 4,740
glioblastoma 11 | 5,792
medulloblastoma, large-cell 9 | 6,241
non-small cell lung cancer 9 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Multiple myeloma 8 | 1,332
acute quadriplegic myopathy 8 | 1,158
Bipolar Disorder 7 | 666
Vascular disease 7 | 319
active Crohn's disease 7 | 922
atypical teratoid / rhabdoid tumor 7 | 5,112
invasive ductal carcinoma 7 | 2,951
juvenile dermatomyositis 7 | 1,187
lung carcinoma 7 | 2,843
Breast cancer 6 | 3,578
Prostatic Neoplasms 6 | 495
ependymoma 6 | 4,679
malignant mesothelioma 6 | 3,232
pancreatic cancer 6 | 2,398
tuberculosis 6 | 2,010
ulcerative colitis 6 | 1,819
Astrocytoma, Pilocytic 5 | 3,081
Liver Cirrhosis, Experimental 5 | 769
adult high grade glioma 5 | 3,801
breast carcinoma 5 | 1,638
cystic fibrosis 5 | 1,696
dermatomyositis 5 | 966
lung adenocarcinoma 5 | 2,716
pituitary cancer 5 | 1,972
Alzheimer's disease 4 | 658
Autosomal recessive predisposition 4 | 1,442
Chemical and Drug Induced Liver Injury 4 | 195
Fatty Liver 4 | 70
Obesity 4 | 678
Parkinson's disease 4 | 392
adrenocortical carcinoma 4 | 1,428
esophageal adenocarcinoma 4 | 737
group 4 medulloblastoma 4 | 1,855
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
non primary Sjogren syndrome sicca 4 | 891
Amyotrophic lateral sclerosis 3 | 451
Asbestosis 3 | 20
Diabetes Mellitus, Insulin-Dependent 3 | 48
Epilepsy 3 | 792
Esophageal Squamous Cell Carcinoma 3 | 77
Liver neoplasms 3 | 130
Myocardial Infarction 3 | 151
Myocardial Ischemia 3 | 169
Pick disease 3 | 1,894
Rheumatoid arthritis 3 | 1,191
Squamous cell carcinoma of esophagus 3 | 77
Toxic encephalopathy 3 | 141
acute myeloid leukemia 3 | 783
aldosterone-producing adenoma 3 | 665
astrocytoma 3 | 1,146
fibroadenoma 3 | 559
group 3 medulloblastoma 3 | 4,104
hepatocellular carcinoma 3 | 547
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
Arthritis, Juvenile 2 | 126
Carcinoma, Hepatocellular 2 | 228
Cholestasis 2 | 155
Chronic Lymphocytic Leukemia 2 | 262
Depressive disorder 2 | 409
Diabetes Mellitus, Type 2 2 | 142
Down syndrome 2 | 499
Duchenne muscular dystrophy 2 | 601
Juvenile arthritis 2 | 126
Kidney disease 2 | 430
Liver carcinoma 2 | 240
Mental Depression 2 | 333
Multiple Sclerosis 2 | 540
Necrosis 2 | 53
Neurodegenerative disease 2 | 414
Neuropathy 2 | 261
Polycystic ovary syndrome 2 | 360
Reperfusion Injury 2 | 86
Schizophrenia 2 | 1,160
X-linked cerebral adrenoleukodystrophy 2 | 116
active ulcerative colitis 2 | 764
astrocytic glioma 2 | 2,597
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
cutaneous lupus erythematosus 2 | 1,057
ductal carcinoma in situ 2 | 1,745
gastric cancer 2 | 459
gastric carcinoma 2 | 807
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
oligodendroglioma 2 | 2,850
pediatric high grade glioma 2 | 1,064
primary pancreatic ductal adenocarcinoma 2 | 1,109
progressive supranuclear palsy 2 | 676
spina bifida 2 | 1,074
subependymal giant cell astrocytoma 2 | 2,287

Tissue

Blood and immune system 27 | 16,909
Digestive Tract 27 | 17,369
Endocrine System 27 | 18,159
Female tissues 27 | 17,400
Liver and Pancreas 27 | 16,750
Male tissues 27 | 17,142
Respiratory system 27 | 16,393
Skin and soft tissues 27 | 17,230
Urinary Tract 27 | 16,678
Cardiovascular System 26 | 15,192
Nervous System 26 | 16,725

Target Family

Non-IDG 12 | 12,091
Enzyme 7 | 4,145
Transcription Factor 6 | 1,400
Kinase 3 | 634

WikiPathways Pathway

Photodynamic therapy-induced u... 28 | 28
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Calreticulin CALR Tbio Non-IDG -3.19563 1544.2 778
Tribbles homolog 3 TRIB3 Tbio Kinase -1.93599 97.7 421
Bcl-2-binding component 3 BBC3 Tbio Non-IDG -2.02081 88.0 559
Bcl-2-like protein 11 BCL2L11 Tbio Non-IDG -3.18092 1465.8 931
78 kDa glucose-regulated protein HSPA5 Tchem Non-IDG -3.35010 2184.4 1074
Ubiquitin-conjugating enzyme E2 E1 UBE2E1 Tbio Non-IDG -1.20770 12.4 78
Serine/threonine-protein kinase/endoribonuclease IRE1 ERN1 Tchem Kinase -2.44644 224.3 489
Protein disulfide-isomerase A6 PDIA6 Tbio Enzyme -1.61328 35.2 152
Protein phosphatase 1 regulatory subunit 15A PPP1R15A Tbio Enzyme -2.13768 136.4 173
ER degradation-enhancing alpha-mannosidase-like protein 1 EDEM1 Tbio Enzyme -1.74775 56.3 69