Development Level

Tbio 18 | 10,625
Tchem 10 | 1,890

IMPC Phenotype

preweaning lethality, complete... 3 | 633
embryonic lethality prior to t... 2 | 187
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal neural tube closure 1 | 37
abnormal retinal pigmentation 1 | 61
cataract 1 | 26
decreased IgG1 level 1 | 4
decreased T cell number 1 | 31
decreased body weight 1 | 174
decreased circulating choleste... 1 | 85
decreased circulating insulin ... 1 | 75
decreased circulating triglyce... 1 | 83
decreased hemoglobin content 1 | 53
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased erythrocyte cell num... 1 | 26
increased grip strength 1 | 83
increased lean body mass 1 | 107
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased red blood cell distr... 1 | 21
increased total body fat amoun... 1 | 57
vertebral fusion 1 | 23

Disease

ovarian cancer 18 | 8,491
Cancer 16 | 2,346
psoriasis 14 | 6,685
osteosarcoma 13 | 7,933
diabetes mellitus 12 | 1,663
lung cancer 12 | 4,473
glioblastoma 11 | 5,572
medulloblastoma, large-cell 9 | 6,234
non-small cell lung cancer 9 | 2,798
Multiple myeloma 8 | 1,327
acute quadriplegic myopathy 8 | 1,157
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
Vascular disease 7 | 281
active Crohn's disease 7 | 918
invasive ductal carcinoma 7 | 2,950
juvenile dermatomyositis 7 | 1,189
lung carcinoma 7 | 2,844
ulcerative colitis 7 | 2,087
Prostatic Neoplasms 6 | 471
atypical teratoid / rhabdoid tumor 6 | 4,369
malignant mesothelioma 6 | 3,163
pancreatic cancer 6 | 2,300
Breast cancer 5 | 3,098
breast carcinoma 5 | 1,614
cystic fibrosis 5 | 1,670
dermatomyositis 5 | 966
lung adenocarcinoma 5 | 2,714
pediatric high grade glioma 5 | 2,712
pilocytic astrocytoma 5 | 3,086
pituitary cancer 5 | 1,972
Squamous cell carcinoma of esophagus 4 | 82
adrenocortical carcinoma 4 | 1,427
esophageal adenocarcinoma 4 | 737
group 4 medulloblastoma 4 | 1,875
interstitial cystitis 4 | 2,299
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
non primary Sjogren syndrome sicca 4 | 840
tuberculosis 4 | 1,563
Alzheimer's disease 3 | 644
Amyotrophic Lateral Sclerosis 3 | 432
Asbestosis 3 | 10
Bipolar Disorder 3 | 266
Myocardial Ischemia 3 | 169
Obesity 3 | 616
Parkinson's disease 3 | 364
Pick disease 3 | 1,893
Rheumatoid Arthritis 3 | 1,170
Toxic encephalopathy 3 | 131
acute myeloid leukemia 3 | 785
aldosterone-producing adenoma 3 | 664
astrocytoma 3 | 1,493
ependymoma 3 | 2,514
fibroadenoma 3 | 557
gastric carcinoma 3 | 832
hepatocellular carcinoma 3 | 550
inflammatory breast cancer 3 | 404
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,988
posterior fossa group A ependymoma 3 | 1,511
primary pancreatic ductal adenocarcinoma 3 | 1,271
Down syndrome 2 | 548
Duchenne muscular dystrophy 2 | 602
Epilepsy 2 | 346
Fatty liver disease 2 | 86
Juvenile arthritis 2 | 124
Kidney disease 2 | 397
Liver Cirrhosis, Experimental 2 | 108
Liver carcinoma 2 | 217
Liver neoplasms 2 | 108
MYELODYSPLASTIC SYNDROME 2 | 39
Multiple Sclerosis 2 | 498
Myocardial Infarction 2 | 126
Necrosis 2 | 51
Neurodegenerative disease 2 | 383
Neuropathy 2 | 210
Non-alcoholic Fatty Liver Disease 2 | 40
Peripheral Neuropathy 2 | 303
Polycystic Ovary Syndrome 2 | 334
Reperfusion Injury 2 | 84
X-linked cerebral adrenoleukodystrophy 2 | 115
adult high grade glioma 2 | 2,148
astrocytic glioma 2 | 2,241
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
cutaneous lupus erythematosus 2 | 1,056
ductal carcinoma in situ 2 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
medulloblastoma 2 | 1,524
non-small cell lung carcinoma 2 | 413
oligodendroglioma 2 | 2,849
progressive supranuclear palsy 2 | 674
sarcoidosis 2 | 368
sonic hedgehog group medulloblastoma 2 | 1,482
spina bifida 2 | 1,064
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis and treatment for 3 months 2 | 327
Dermatologic disorders 1 | 65
Endometrial Neoplasms 1 | 50
Gastrointestinal Diseases 1 | 12
Kidney Diseases 1 | 86
Liver diseases 1 | 66
nervous system disorder 1 | 53

Tissue

Blood and immune system 28 | 17,994
Digestive Tract 28 | 18,472
Female tissues 28 | 18,646
Liver and Pancreas 28 | 18,135
Male tissues 28 | 17,968
Nervous System 28 | 18,560
Respiratory system 28 | 17,483
Urinary Tract 28 | 18,443
Cardiovascular System 27 | 17,957
Endocrine System 27 | 18,511
Skin and soft tissues 27 | 18,114

Target Family

Non-IDG 12 | 11,969
Enzyme 7 | 4,146
Transcription Factor 6 | 1,400
Kinase 3 | 634

WikiPathways Pathway

Photodynamic therapy-induced u... 28 | 28
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 128 | 128
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bcl-2-like protein 11 BCL2L11 Tbio Non-IDG -3.14287 1340.6 903
Calreticulin CALR Tbio Non-IDG -3.16449 1423.9 650
Eukaryotic translation initiation factor 2-alpha kinase 3 EIF2AK3 Tchem Kinase -3.01129 806.4 424
Eukaryotic translation initiation factor 2A EIF2A Tbio Non-IDG -0.57210 3.87 227
Tribbles homolog 3 TRIB3 Tbio Kinase -1.88815 82.8 376
Serine/threonine-protein kinase/endoribonuclease IRE1 ERN1 Tchem Kinase -2.40076 210.9 439
DNA damage-inducible transcript 3 protein DDIT3 Tchem Transcription Factor -2.90188 671.8 624
Tryptophan--tRNA ligase, cytoplasmic WARS Tbio Enzyme -2.71095 974.3 154
Endoplasmin HSP90B1 Tchem Non-IDG -2.74041 604.5 748
Estrogen sulfotransferase SULT1E1 Tchem Enzyme -2.94205 866.8 134