Development Level

Tbio 41 | 11,651
Tchem 18 | 1,388
Tclin 5 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal lens morphology 2 | 81
abnormal retina morphology 2 | 71
cataract 2 | 92
decreased body weight 2 | 161
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
hypoactivity 2 | 132
mydriasis 2 | 6
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal gait 1 | 69
abnormal retinal outer nuclear... 1 | 3
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal vertebrae morphology 1 | 18
corneal opacity 1 | 32
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged spleen 1 | 41
increased body length 1 | 32
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
irregularly shaped pupil 1 | 7
prenatal lethality prior to he... 1 | 87
prolonged QRS complex duration 1 | 8
short tibia 1 | 97
thrombocytopenia 1 | 56
vertebral transformation 1 | 12

Disease

Carcinoma 55 | 11,493
Adenoid Cystic Carcinoma 54 | 99
Carcinoma, Adenoid Cystic 54 | 99
ovarian cancer 49 | 8,520
Breast cancer 37 | 3,578
Cancer 35 | 2,499
lung cancer 34 | 4,740
glioblastoma 33 | 5,792
osteosarcoma 33 | 7,950
Kidney cancer 31 | 2,613
psoriasis 31 | 6,694
medulloblastoma, large-cell 30 | 6,241
atypical teratoid / rhabdoid tumor 28 | 5,112
group 3 medulloblastoma 27 | 4,104
ependymoma 25 | 4,679
Intellectual disability 22 | 1,016
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
primitive neuroectodermal tumor 19 | 3,035
breast carcinoma 18 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
malignant mesothelioma 18 | 3,232
Dull intelligence 17 | 645
Liver cancer 17 | 604
Low intelligence 17 | 645
Mental Retardation 17 | 645
Mental deficiency 17 | 645
Poor school performance 17 | 645
astrocytic glioma 17 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
oligodendroglioma 17 | 2,850
Breast Neoplasms 16 | 445
Cognitive delay 16 | 608
Global developmental delay 16 | 608
Mammary Neoplasms 16 | 425
Mental and motor retardation 16 | 608
Epilepsy 15 | 792
Immune system cancer 15 | 140
Muscle hypotonia 15 | 571
Schizophrenia 15 | 1,160
Seizures 15 | 596
Short stature 15 | 531
lung adenocarcinoma 15 | 2,716
pancreatic cancer 15 | 2,398
Rheumatoid arthritis 14 | 1,191
invasive ductal carcinoma 14 | 2,951
non-small cell lung cancer 14 | 2,890
Byzanthine arch palate 13 | 194
Cryptorchidism 13 | 296
Lymphoid leukemia 13 | 160
Prostatic Neoplasms 13 | 495
Small head 13 | 374
Strabismus 13 | 270
adult high grade glioma 13 | 3,801
ductal carcinoma in situ 13 | 1,745
Blepharoptosis 12 | 231
Endometrial cancer 12 | 311
juvenile dermatomyositis 12 | 1,187
subependymal giant cell astrocytoma 12 | 2,287
tuberculosis 12 | 2,010
ulcerative colitis 12 | 1,819
Acquired scoliosis 11 | 281
Bladder Neoplasm 11 | 112
Carcinoma, Squamous Cell 11 | 110
Curvature of spine 11 | 282
Hypoplastic mandible condyle 11 | 275
Mandibular hypoplasia 11 | 275
Micrognathism 11 | 275
Squamous cell carcinoma 11 | 129
Stomach Neoplasms 11 | 300
Urinary Bladder Neoplasms 11 | 114
acute quadriplegic myopathy 11 | 1,158
nasopharyngeal carcinoma 11 | 1,058
Broad flat nasal bridge 10 | 236
Concave bridge of nose 10 | 195
Congenital Epicanthus 10 | 177
Congenital deafness 10 | 185
Deafness 10 | 198
Depressed nasal bridge 10 | 195
Depressed nasal root/bridge 10 | 195
Downward slant of palpebral fissure 10 | 158
Feeding difficulties in infancy 10 | 175
Hearing Loss, Partial 10 | 185
Melanoma 10 | 711
Multiple myeloma 10 | 1,332
Nasal bridge wide 10 | 236
Skin cancer 10 | 469
hearing impairment 10 | 199
pituitary cancer 10 | 1,972
Astrocytoma, Pilocytic 9 | 3,081
Autistic Disorder 9 | 364
Bipolar Disorder 9 | 666
Carcinoma, Hepatocellular 9 | 228
Failure to gain weight 9 | 365
Liver carcinoma 9 | 240
Lung Neoplasms 9 | 232
Orbital separation excessive 9 | 244
Pediatric failure to thrive 9 | 365
astrocytoma 9 | 1,146
diabetes mellitus 9 | 1,728
lung carcinoma 9 | 2,843

Tissue

Endocrine System 64 | 18,159
Female tissues 64 | 17,400
Male tissues 64 | 17,142
Nervous System 64 | 16,725
Urinary Tract 64 | 16,678
Digestive Tract 63 | 17,369
Skin and soft tissues 63 | 17,230
Blood and immune system 62 | 16,909
Cardiovascular System 62 | 15,192
Liver and Pancreas 62 | 16,750
Respiratory system 62 | 16,393

Target Family

Non-IDG 16 | 12,091
Transcription Factor 15 | 1,400
Epigenetic 13 | 242
Kinase 12 | 634
Enzyme 7 | 4,145
TF/Epigenetic 1 | 38

WikiPathways Pathway

Pathways Affected in Adenoid C... 64 | 64
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific NSD1 Tbio Epigenetic -2.16239 142.5 123
E3 ubiquitin-protein ligase UHRF1 UHRF1 Tbio Epigenetic 0.00000 279
Erbin ERBIN Tbio Non-IDG -1.72357 59.1 117
Protein max MAX Tbio Transcription Factor -2.14268 110.6 398
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.28550 20244.6 3859
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.76784 6081.3 1542
DNA-dependent protein kinase catalytic subunit PRKDC Tchem Kinase -2.85973 723.4 1160
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.11278 12358.0 2705
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.08587 12.0 153