Development Level

Tbio 35 | 10,625
Tchem 24 | 1,890
Tclin 4 | 602
Tdark 1 | 7,003

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

decreased total body fat amoun... 3 | 186
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
decreased bone mineral content 2 | 157
hypoactivity 2 | 89
preweaning lethality, complete... 2 | 633
prolonged QRS complex duration 2 | 2
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal gait 1 | 51
abnormal lens morphology 1 | 73
abnormal sleep behavior 1 | 63
cataract 1 | 26
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased erythrocyte cell num... 1 | 43
decreased heart weight 1 | 44
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular vol... 1 | 50
decreased prepulse inhibition 1 | 52
decreased spleen weight 1 | 13
decreased startle reflex 1 | 48
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
enlarged spleen 1 | 26
increased bone mineral content 1 | 92
increased circulating sodium l... 1 | 71
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased sacral vertebrae num... 1 | 62
mydriasis 1 | 9
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82
thrombocytopenia 1 | 46
trunk curl 1 | 15
vertebral transformation 1 | 12

Disease

Adenoid Cystic Carcinoma 54 | 99
ovarian cancer 48 | 8,491
Carcinoma 36 | 2,147
Cancer 34 | 2,346
osteosarcoma 33 | 7,933
psoriasis 31 | 6,685
medulloblastoma, large-cell 30 | 6,234
Breast cancer 29 | 3,098
glioblastoma 29 | 5,572
lung cancer 27 | 4,473
atypical teratoid / rhabdoid tumor 22 | 4,369
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,956
primitive neuroectodermal tumor 19 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,988
Intellectual disability 17 | 573
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,289
oligodendroglioma 17 | 2,849
Mammary Neoplasms 16 | 410
ependymoma 15 | 2,514
lung adenocarcinoma 15 | 2,714
malignant mesothelioma 15 | 3,163
pediatric high grade glioma 15 | 2,712
Rheumatoid Arthritis 14 | 1,170
astrocytoma 14 | 1,493
group 3 medulloblastoma 14 | 2,254
invasive ductal carcinoma 14 | 2,950
medulloblastoma 14 | 1,524
Prostatic Neoplasms 13 | 471
ductal carcinoma in situ 13 | 1,745
non-small cell lung cancer 13 | 2,798
astrocytic glioma 12 | 2,241
breast carcinoma 12 | 1,614
juvenile dermatomyositis 12 | 1,189
subependymal giant cell astrocytoma 12 | 2,287
ulcerative colitis 12 | 2,087
Bladder Neoplasm 11 | 109
acute quadriplegic myopathy 11 | 1,157
nasopharyngeal carcinoma 11 | 1,056
Multiple myeloma 10 | 1,327
pancreatic cancer 10 | 2,300
pilocytic astrocytoma 10 | 3,086
pituitary cancer 10 | 1,972
tuberculosis 10 | 1,563
Kidney cancer 9 | 121
Lung Neoplasms 9 | 171
Stomach Neoplasms 9 | 282
lung carcinoma 9 | 2,844
sonic hedgehog group medulloblastoma 9 | 1,482
Carcinoma, Transitional Cell 8 | 31
Glioma 8 | 66
Liver carcinoma 8 | 217
Neuroblastoma 8 | 78
Pick disease 8 | 1,893
acute myeloid leukemia 8 | 785
atypical teratoid/rhabdoid tumor 8 | 1,095
dermatomyositis 8 | 966
diabetes mellitus 8 | 1,663
interstitial cystitis 8 | 2,299
Adenoma 7 | 165
Renal Cell Carcinoma 7 | 199
Squamous cell carcinoma of esophagus 7 | 82
adrenocortical carcinoma 7 | 1,427
non-small cell lung carcinoma 7 | 413
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
posterior fossa group B ependymoma 7 | 1,530
Adenocarcinoma 6 | 115
Autistic Disorder 6 | 320
Colorectal Neoplasms 6 | 217
Endometriosis 6 | 535
Lymphoid leukemia 6 | 69
Neoplastic Cell Transformation 6 | 81
Neoplastic Syndromes, Hereditary 6 | 48
Pancreatic Neoplasm 6 | 79
Peripheral Neuropathy 6 | 303
Prostate cancer 6 | 172
Schizophrenia 6 | 503
Waldenstrons macroglobulinemia 6 | 764
adult high grade glioma 6 | 2,148
ovarian neoplasm 6 | 97
posterior fossa group A ependymoma 6 | 1,511
Alzheimer's disease 5 | 644
Ataxia telangiectasia 5 | 32
Craniofacial Abnormalities 5 | 147
Disease Progression 5 | 125
Endometrial cancer 5 | 32
Head and neck squamous cell carcinoma 5 | 12
Heart disease 5 | 279
Immune system cancer 5 | 38
Melanoma 5 | 261
Nijmegen breakage syndrome 5 | 23
Sezary Syndrome 5 | 26
Squamous cell carcinoma 5 | 96
group 4 medulloblastoma 5 | 1,875
hepatocellular carcinoma 5 | 550
spina bifida 5 | 1,064
Down syndrome 4 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 499
chronic rhinosinusitis 4 | 512
colon cancer 4 | 1,475
fibroadenoma 4 | 557

Tissue

Blood and immune system 64 | 17,994
Cardiovascular System 64 | 17,957
Digestive Tract 64 | 18,472
Female tissues 64 | 18,646
Liver and Pancreas 64 | 18,135
Nervous System 64 | 18,560
Endocrine System 63 | 18,511
Male tissues 63 | 17,968
Respiratory system 63 | 17,483
Skin and soft tissues 63 | 18,114
Urinary Tract 63 | 18,443

Target Family

Non-IDG 16 | 11,969
Transcription Factor 15 | 1,400
Epigenetic 13 | 242
Kinase 12 | 634
Enzyme 7 | 4,146
TF/Epigenetic 1 | 38

WikiPathways Pathway

Pathways Affected in Adenoid C... 64 | 64
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 128 | 128
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.04868 9.00 130
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.74239 5756.8 1322
Erbin ERBIN Tbio Non-IDG -1.68182 53.5 111
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.09050 11730.8 2241
GTPase HRas HRAS Tchem Enzyme -3.99319 9497.9 312
Fibroblast growth factor 16 FGF16 Tbio Non-IDG -1.74106 54.5 120
E3 ubiquitin-protein ligase UHRF1 UHRF1 Tchem Epigenetic 0.00000 269
Probable JmjC domain-containing histone demethylation protein 2C JMJD1C Tbio Epigenetic -1.16854 16.4 86
RAF proto-oncogene serine/threonine-protein kinase RAF1 Tclin Kinase -3.09190 1147.5 1943