Development Level

Tbio 26 | 11,445
Tclin 14 | 613
Tchem 12 | 1,598
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 7 | 979
preweaning lethality, incomple... 4 | 499
abnormal retina morphology 3 | 71
abnormal skin morphology 2 | 50
decreased circulating fructosa... 2 | 30
decreased circulating serum al... 2 | 82
edema 2 | 59
embryonic lethality prior to t... 2 | 278
increased neutrophil cell numb... 2 | 46
short tibia 2 | 97
abnormal bone mineralization 1 | 38
abnormal cecum morphology 1 | 7
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal eye morphology 1 | 68
abnormal hair texture 1 | 4
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal startle reflex 1 | 15
anophthalmia 1 | 33
decreased body weight 1 | 161
decreased circulating total pr... 1 | 49
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased lymphocyte cell numb... 1 | 83
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged cecum 1 | 5
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
enlarged uterus 1 | 11
fusion of vertebral arches 1 | 7
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased eosinophil cell numb... 1 | 11
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
small superior vagus ganglion 1 | 74
vertebral fusion 1 | 23

Disease

Carcinoma 38 | 11,493
ovarian cancer 36 | 8,520
osteosarcoma 26 | 7,950
Cancer 24 | 2,499
psoriasis 23 | 6,694
atypical teratoid / rhabdoid tumor 21 | 5,112
glioblastoma 20 | 5,792
lung cancer 20 | 4,740
medulloblastoma, large-cell 20 | 6,241
pancreatic cancer 20 | 2,398
Breast cancer 18 | 3,578
ependymoma 16 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
non-small cell lung cancer 16 | 2,890
Astrocytoma, Pilocytic 15 | 3,081
Duchenne muscular dystrophy 12 | 601
breast carcinoma 12 | 1,638
juvenile dermatomyositis 12 | 1,187
malignant mesothelioma 12 | 3,232
tuberculosis 12 | 2,010
Multiple myeloma 11 | 1,332
Ocular hypertension 11 | 42
adult high grade glioma 11 | 3,801
diabetes mellitus 11 | 1,728
interstitial cystitis 11 | 2,312
invasive ductal carcinoma 11 | 2,951
lung adenocarcinoma 11 | 2,716
lung carcinoma 11 | 2,843
primitive neuroectodermal tumor 11 | 3,035
Malignant tumor of prostate 10 | 26
Nephroblastoma 10 | 51
Open-angle glaucoma 10 | 27
group 4 medulloblastoma 10 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
primary pancreatic ductal adenocarcinoma 10 | 1,109
subependymal giant cell astrocytoma 10 | 2,287
Acute lymphoid leukemia 9 | 25
Anaplastic large T-cell systemic malignant lymphoma 9 | 10
Burkitt's lymphoma 9 | 15
Carcinoma of breast 9 | 11
Carcinoma of female breast 9 | 20
Diffuse non-Hodgkin's lymphoma, large cell 9 | 12
Follicular non-Hodgkin's lymphoma 9 | 17
Gestational trophoblastic neoplasia 9 | 14
HER2-positive carcinoma of breast 9 | 21
Hodgkin's disease 9 | 18
Hypertensive disorder 9 | 56
Kaposi's sarcoma 9 | 22
Langerhans cell histiocytosis, disseminated 9 | 10
Liposarcoma 9 | 20
Liver Cirrhosis, Experimental 9 | 769
Malignant tumor of head and/or neck 9 | 15
Malignant tumor of ovary 9 | 25
Malignant tumor of stomach 9 | 12
Malignant tumor of testis 9 | 11
Metastatic Breast Carcinoma 9 | 21
Metastatic Prostate Carcinoma 9 | 18
Mycosis fungoides 9 | 29
Neuroblastoma 9 | 80
Non-Hodgkin's lymphoma 9 | 22
Rhabdomyosarcoma 9 | 39
Rheumatoid arthritis 9 | 1,191
Schizophrenia 9 | 1,160
Secondary malignant neoplasm of pancreas 9 | 10
astrocytic glioma 9 | 2,597
astrocytoma 9 | 1,146
colon cancer 9 | 1,478
cystic fibrosis 9 | 1,696
oligodendroglioma 9 | 2,850
transitional cell carcinoma 9 | 22
ulcerative colitis 9 | 1,819
Kidney cancer 8 | 2,613
Lissencephaly 8 | 69
Animal Mammary Neoplasms 7 | 136
Breast Neoplasms 7 | 445
Down syndrome 7 | 499
Intellectual disability 7 | 1,016
Mammary Neoplasms 7 | 425
Mammary Neoplasms, Animal 7 | 136
Mammary Neoplasms, Experimental 7 | 154
Waldenstrons macroglobulinemia 7 | 765
adrenocortical carcinoma 7 | 1,428
dermatomyositis 7 | 966
gastric cancer 7 | 459
gastric carcinoma 7 | 807
group 3 medulloblastoma 7 | 4,104
mucosa-associated lymphoid tissue lymphoma 7 | 484
pancreatic carcinoma 7 | 562
Becker muscular dystrophy 6 | 191
Condyloma acuminatum 6 | 7
Kidney disease 6 | 430
Neoplasm Invasiveness 6 | 161
Neoplasm Metastasis 6 | 168
acute quadriplegic myopathy 6 | 1,158
ductal carcinoma in situ 6 | 1,745
hepatocellular carcinoma 6 | 547
pituitary cancer 6 | 1,972
primary Sjogren syndrome 5 | 735

Tissue

Endocrine System 53 | 18,159
Female tissues 53 | 17,400
Blood and immune system 52 | 16,909
Cardiovascular System 52 | 15,192
Digestive Tract 52 | 17,369
Male tissues 52 | 17,142
Nervous System 52 | 16,725
Skin and soft tissues 52 | 17,230
Urinary Tract 52 | 16,678
Liver and Pancreas 51 | 16,750
Respiratory system 50 | 16,393

Target Family

Non-IDG 47 | 12,091
Kinase 5 | 634
Enzyme 2 | 4,145

WikiPathways Pathway

Pathogenic Escherichia coli in... 54 | 54
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90
Tubulin beta-6 chain TUBB6 Tclin Non-IDG -0.94163 8.01 85
Tubulin alpha-8 chain TUBA8 Tbio Non-IDG -0.87821 7.61 118
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
Claudin-1 CLDN1 Tbio Non-IDG -2.07626 126.7 593
Keratin, type I cytoskeletal 18 KRT18 Tbio Non-IDG -3.05211 1057.8 1953
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Actin, cytoplasmic 2 ACTG1 Tbio Non-IDG -2.50312 297.3 225
Lymphocyte antigen 96 LY96 Tchem Non-IDG -2.77678 541.2 369
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380