Development Level

Tbio 45 | 11,445
Tchem 14 | 1,598
Tclin 9 | 613
Tdark 1 | 6,588

Collection

GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 4 | 979
short tibia 3 | 97
cardiovascular system phenotyp... 2 | 36
decreased bone mineral content 2 | 151
decreased lean body mass 2 | 135
increased total body fat amoun... 2 | 134
male infertility 2 | 123
preweaning lethality, incomple... 2 | 499
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
abnormal behavioral response t... 1 | 66
abnormal pelvic girdle bone mo... 1 | 12
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating total pr... 1 | 49
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
improved glucose tolerance 1 | 79
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
small liver 1 | 8
small spleen 1 | 19
thrombocytopenia 1 | 56

Disease

ovarian cancer 51 | 8,520
Carcinoma 41 | 11,493
lung cancer 29 | 4,740
osteosarcoma 29 | 7,950
psoriasis 25 | 6,694
Multiple myeloma 23 | 1,332
atypical teratoid / rhabdoid tumor 21 | 5,112
Breast cancer 20 | 3,578
medulloblastoma, large-cell 20 | 6,241
glioblastoma 19 | 5,792
Cancer 17 | 2,499
non-small cell lung cancer 17 | 2,890
group 3 medulloblastoma 16 | 4,104
ependymoma 13 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
lung adenocarcinoma 13 | 2,716
pancreatic cancer 13 | 2,398
Astrocytoma, Pilocytic 12 | 3,081
adult high grade glioma 12 | 3,801
oligodendroglioma 12 | 2,850
primitive neuroectodermal tumor 12 | 3,035
breast carcinoma 11 | 1,638
colon cancer 11 | 1,478
malignant mesothelioma 11 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Parkinson's disease 10 | 392
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
subependymal giant cell astrocytoma 10 | 2,287
Acute lymphoid leukemia 9 | 25
Anaplastic large T-cell systemic malignant lymphoma 9 | 10
Burkitt's lymphoma 9 | 15
Carcinoma of breast 9 | 11
Carcinoma of female breast 9 | 20
Diffuse non-Hodgkin's lymphoma, large cell 9 | 12
Follicular non-Hodgkin's lymphoma 9 | 17
Gestational trophoblastic neoplasia 9 | 14
HER2-positive carcinoma of breast 9 | 21
Hodgkin's disease 9 | 18
Hypertensive disorder 9 | 56
Kaposi's sarcoma 9 | 22
Langerhans cell histiocytosis, disseminated 9 | 10
Liposarcoma 9 | 20
Malignant tumor of head and/or neck 9 | 15
Malignant tumor of ovary 9 | 25
Malignant tumor of prostate 9 | 26
Malignant tumor of stomach 9 | 12
Malignant tumor of testis 9 | 11
Metastatic Breast Carcinoma 9 | 21
Metastatic Prostate Carcinoma 9 | 18
Mycosis fungoides 9 | 29
Nephroblastoma 9 | 51
Neuroblastoma 9 | 80
Neurodegenerative disease 9 | 414
Non-Hodgkin's lymphoma 9 | 22
Ocular hypertension 9 | 42
Open-angle glaucoma 9 | 27
Rhabdomyosarcoma 9 | 39
Secondary malignant neoplasm of pancreas 9 | 10
dermatomyositis 9 | 966
interstitial cystitis 9 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
invasive ductal carcinoma 9 | 2,951
transitional cell carcinoma 9 | 22
astrocytic glioma 8 | 2,597
diabetes mellitus 8 | 1,728
tuberculosis 8 | 2,010
Amyotrophic lateral sclerosis 7 | 451
HIV Infections 7 | 102
Kidney cancer 7 | 2,613
juvenile dermatomyositis 7 | 1,187
lung carcinoma 7 | 2,843
non primary Sjogren syndrome sicca 7 | 891
Condyloma acuminatum 6 | 7
Lissencephaly 6 | 69
Pick disease 6 | 1,894
Rheumatoid arthritis 6 | 1,191
Vascular disease 6 | 319
active Crohn's disease 6 | 922
astrocytoma 6 | 1,146
pituitary cancer 6 | 1,972
Breast Neoplasms 5 | 445
Down syndrome 5 | 499
Duchenne muscular dystrophy 5 | 601
Intellectual disability 5 | 1,016
Mammary Neoplasms 5 | 425
Toxic encephalopathy 5 | 141
Waldenstrons macroglobulinemia 5 | 765
acute quadriplegic myopathy 5 | 1,158
cutaneous lupus erythematosus 5 | 1,057
cystic fibrosis 5 | 1,696
esophageal adenocarcinoma 5 | 737
nasopharyngeal carcinoma 5 | 1,058
tuberculosis and treatment for 6 months 5 | 409
ulcerative colitis 5 | 1,819
Autosomal recessive predisposition 4 | 1,442
Bipolar Disorder 4 | 666
Cognitive delay 4 | 608
Global developmental delay 4 | 608
Mental and motor retardation 4 | 608
hepatocellular carcinoma 4 | 547

Tissue

Endocrine System 69 | 18,159
Female tissues 69 | 17,400
Blood and immune system 68 | 16,909
Digestive Tract 68 | 17,369
Male tissues 68 | 17,142
Skin and soft tissues 68 | 17,230
Urinary Tract 68 | 16,678
Cardiovascular System 67 | 15,192
Nervous System 67 | 16,725
Liver and Pancreas 66 | 16,750
Respiratory system 66 | 16,393

Target Family

Non-IDG 40 | 12,091
Enzyme 27 | 4,145
GPCR 1 | 408
Kinase 1 | 634

WikiPathways Pathway

Parkin-Ubiquitin Proteasomal S... 69 | 69
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tubulin alpha-8 chain TUBA8 Tbio Non-IDG -0.87821 7.61 118
Tubulin beta-6 chain TUBB6 Tclin Non-IDG -0.94163 8.01 85
E3 ubiquitin-protein ligase RNF19A RNF19A Tbio Enzyme -1.12489 15.5 142
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90
Heat shock-related 70 kDa protein 2 HSPA2 Tbio Non-IDG -1.98655 104.3 162
Septin-5 SEPT5 Tbio Non-IDG -1.71017 49.4 178
Heat shock 70 kDa protein 1A HSPA1B Tchem Non-IDG -3.10995 0.00000 1174
Heat shock 70 kDa protein 1B HSPA1B Tbio Non-IDG -1.61862 0.00000 60
Ubiquitin-conjugating enzyme E2 G1 UBE2G1 Tbio Non-IDG -0.84360 6.17 155
26S proteasome regulatory subunit 10B PSMC6 Tbio Enzyme -2.65165 339.0 214