Development Level

Tbio 40 | 11,445
Tchem 20 | 1,598
Tclin 5 | 613
Tdark 2 | 6,588

IMPC Phenotype

abnormal lens morphology 4 | 81
cataract 3 | 92
decreased vertical activity 3 | 208
decreased circulating triglyce... 2 | 79
decreased heart weight 2 | 27
decreased lean body mass 2 | 135
decreased mean corpuscular vol... 2 | 79
increased circulating HDL chol... 2 | 80
increased circulating bilirubi... 2 | 16
increased circulating choleste... 2 | 66
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal seminal vesicle morph... 1 | 114
abnormal tibia morphology 1 | 14
abnormal vertebrae morphology 1 | 18
absent optic nerve 1 | 2
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased large unstained cell... 1 | 11
decreased neutrophil cell numb... 1 | 42
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating phosphat... 1 | 26
increased circulating unsatura... 1 | 1
increased grip strength 1 | 41
increased heart weight 1 | 62
increased leukocyte cell numbe... 1 | 47
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56

Disease

Carcinoma 50 | 11,493
psoriasis 41 | 6,694
ovarian cancer 33 | 8,520
Obesity 31 | 678
osteosarcoma 27 | 7,950
diabetes mellitus 26 | 1,728
medulloblastoma, large-cell 25 | 6,241
lung cancer 23 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,962
invasive ductal carcinoma 22 | 2,951
malignant mesothelioma 22 | 3,232
ductal carcinoma in situ 20 | 1,745
glioblastoma 19 | 5,792
ependymoma 18 | 4,679
Atherosclerosis 17 | 291
Lipid metabolism disorder 17 | 114
Coronary artery disease 16 | 268
atypical teratoid / rhabdoid tumor 16 | 5,112
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
lung carcinoma 16 | 2,843
Atopic dermatitis 15 | 952
Breast cancer 15 | 3,578
Cancer 15 | 2,499
breast carcinoma 15 | 1,638
group 3 medulloblastoma 15 | 4,104
interstitial cystitis 15 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
colon cancer 14 | 1,478
Fatty liver disease 13 | 103
Liver Cirrhosis, Experimental 13 | 769
ulcerative colitis 13 | 1,819
Astrocytoma, Pilocytic 12 | 3,081
Schizophrenia 12 | 1,160
active Crohn's disease 12 | 922
active ulcerative colitis 12 | 764
astrocytoma 12 | 1,146
non-small cell lung cancer 12 | 2,890
adult high grade glioma 11 | 3,801
astrocytic glioma 11 | 2,597
oligodendroglioma 11 | 2,850
pancreatic cancer 11 | 2,398
pituitary cancer 11 | 1,972
Autosomal recessive predisposition 10 | 1,442
Hypertension 10 | 396
lung adenocarcinoma 10 | 2,716
primitive neuroectodermal tumor 10 | 3,035
adrenocortical carcinoma 9 | 1,428
fibroadenoma 9 | 559
Carcinoma, Hepatocellular 8 | 228
Epilepsy 8 | 792
Hypertensive disease 8 | 292
Kidney cancer 8 | 2,613
Liver carcinoma 8 | 240
Rheumatoid arthritis 8 | 1,191
acute quadriplegic myopathy 8 | 1,158
mucosa-associated lymphoid tissue lymphoma 8 | 484
nephrosclerosis 8 | 333
subependymal giant cell astrocytoma 8 | 2,287
tuberculosis 8 | 2,010
Diabetes Mellitus, Experimental 7 | 108
Heart disease 7 | 306
Hepatomegaly 7 | 285
Hyperglycemia 7 | 137
Hypoglycemia 7 | 152
Kidney disease 7 | 430
Seizures 7 | 596
cutaneous lupus erythematosus 7 | 1,057
cystic fibrosis 7 | 1,696
group 4 medulloblastoma 7 | 1,855
Animal Mammary Neoplasms 6 | 136
Breast Neoplasms 6 | 445
Chemical and Drug Induced Liver Injury 6 | 195
Heart failure 6 | 162
Hypercholesterolemia 6 | 44
Hypertriglyceridemia 6 | 17
Liver Failure 6 | 73
Mammary Neoplasms 6 | 425
Mammary Neoplasms, Animal 6 | 136
Mammary Neoplasms, Experimental 6 | 154
Myocardial Ischemia 6 | 169
Polycystic ovary syndrome 6 | 360
Steatohepatitis 6 | 44
nasopharyngeal carcinoma 6 | 1,058
pediatric high grade glioma 6 | 1,064
Adrenoleukodystrophy 5 | 29
Bipolar Disorder 5 | 666
Cerebrovascular disease 5 | 238
Cholestasis 5 | 155
Down syndrome 5 | 499
Hyperinsulinism 5 | 133
Liver disease 5 | 237
Muscle hypotonia 5 | 571
Pick disease 5 | 1,894
Weight Gain 5 | 100
Zellweger syndrome 5 | 37
aldosterone-producing adenoma 5 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
hereditary spastic paraplegia 5 | 318
non primary Sjogren syndrome sicca 5 | 891

Tissue

Endocrine System 67 | 18,159
Digestive Tract 66 | 17,369
Female tissues 66 | 17,400
Liver and Pancreas 65 | 16,750
Skin and soft tissues 65 | 17,230
Male tissues 63 | 17,142
Urinary Tract 63 | 16,678
Blood and immune system 62 | 16,909
Nervous System 61 | 16,725
Respiratory system 60 | 16,393
Cardiovascular System 58 | 15,192

Target Family

Enzyme 25 | 4,145
Non-IDG 25 | 12,091
Nuclear Receptor 7 | 48
Kinase 5 | 634
Transporter 5 | 473

WikiPathways Pathway

PPAR signaling pathway 67 | 67
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.74279 54.0 126
Long-chain-fatty-acid--CoA ligase 5 ACSL5 Tbio Enzyme -1.98202 97.3 170
Fatty acid-binding protein, adipocyte FABP4 Tchem Non-IDG -2.73935 617.7 605
Fatty acid desaturase 2 FADS2 Tbio Enzyme -2.55411 349.6 135
Fatty acid-binding protein, epidermal FABP5 Tchem Non-IDG -1.94229 141.2 226
Bile acyl-CoA synthetase SLC27A5 Tbio Transporter -2.32176 196.8 181
Fatty acid-binding protein, intestinal FABP2 Tchem Non-IDG -2.54500 414.9 369
Gastrotropin FABP6 Tbio Non-IDG -2.18288 154.9 136
NADP-dependent malic enzyme ME1 Tchem Non-IDG -1.98857 92.8 234
Sorbin and SH3 domain-containing protein 1 SORBS1 Tbio Non-IDG -1.57341 40.2 224