Development Level

Tbio 15 | 11,445
Tchem 8 | 1,598
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal embryo size 1 | 220
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal seminal vesicle morph... 1 | 114
abnormal vertebrae morphology 1 | 18
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased heart weight 1 | 27
decreased large unstained cell... 1 | 11
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
edema 1 | 59
female infertility 1 | 60
hyperactivity 1 | 148
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating phosphat... 1 | 26
increased circulating unsatura... 1 | 1
increased leukocyte cell numbe... 1 | 47
increased startle reflex 1 | 112
male infertility 1 | 123
microphthalmia 1 | 26

Disease

Carcinoma 21 | 11,493
ovarian cancer 16 | 8,520
psoriasis 15 | 6,694
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
malignant mesothelioma 10 | 3,232
medulloblastoma, large-cell 10 | 6,241
osteosarcoma 10 | 7,950
Lipid metabolism disorder 9 | 114
Obesity 9 | 678
diabetes mellitus 9 | 1,728
Atherosclerosis 8 | 291
Cancer 8 | 2,499
astrocytoma 8 | 1,146
colon cancer 8 | 1,478
glioblastoma 8 | 5,792
invasive ductal carcinoma 8 | 2,951
group 3 medulloblastoma 7 | 4,104
Coronary artery disease 6 | 268
atypical teratoid / rhabdoid tumor 6 | 5,112
ductal carcinoma in situ 6 | 1,745
ependymoma 6 | 4,679
oligodendroglioma 6 | 2,850
ulcerative colitis 6 | 1,819
Astrocytoma, Pilocytic 5 | 3,081
Chemical and Drug Induced Liver Injury 5 | 195
Fatty liver disease 5 | 103
Hepatomegaly 5 | 285
Multiple myeloma 5 | 1,332
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
lung cancer 5 | 4,740
primitive neuroectodermal tumor 5 | 3,035
Animal Mammary Neoplasms 4 | 136
Carcinoma, Hepatocellular 4 | 228
Cholestasis 4 | 155
Chronic Lymphocytic Leukemia 4 | 262
Hypertension 4 | 396
Hypoglycemia 4 | 152
Kidney cancer 4 | 2,613
Kidney disease 4 | 430
Liver carcinoma 4 | 240
Lung Neoplasms 4 | 232
Mammary Neoplasms, Animal 4 | 136
Mammary Neoplasms, Experimental 4 | 154
Prostatic Neoplasms 4 | 495
Stomach Neoplasms 4 | 300
Vascular disease 4 | 319
adrenocortical carcinoma 4 | 1,428
adult high grade glioma 4 | 3,801
interstitial cystitis 4 | 2,312
nasopharyngeal carcinoma 4 | 1,058
pediatric high grade glioma 4 | 1,064
subependymal giant cell astrocytoma 4 | 2,287
Adenocarcinoma 3 | 122
Adenoma 3 | 167
Anemia 3 | 365
Autosomal recessive predisposition 3 | 1,442
Breast cancer 3 | 3,578
Cardiomegaly 3 | 116
Comatose 3 | 56
Elevated hepatic transaminases 3 | 81
Epilepsy 3 | 792
Fatigue 3 | 182
Fatty Liver 3 | 70
Hepatic enzyme increased 3 | 81
Hypercholesterolemia 3 | 44
Hypercholesterolemia, Familial 3 | 23
Hypertriglyceridemia 3 | 17
Kidney Diseases 3 | 114
Kidney Failure, Chronic 3 | 46
Lethargy 3 | 77
Liver Cirrhosis, Experimental 3 | 769
Liver Dysfunction 3 | 99
Liver Failure 3 | 73
Liver disease 3 | 237
Liver enzymes abnormal 3 | 81
Liver function test increased 3 | 81
Liver function tests abnormal finding 3 | 81
Liver neoplasms 3 | 130
Muscle hypotonia 3 | 571
Proteinuria 3 | 144
Schizophrenia 3 | 1,160
Seizures 3 | 596
Stomach cancer 3 | 30
Subclinical abnormal liver function tests 3 | 81
Transaminases increased 3 | 81
Waldenstrons macroglobulinemia 3 | 765
Zellweger syndrome 3 | 37
active Crohn's disease 3 | 922
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
lung adenocarcinoma 3 | 2,716
lung carcinoma 3 | 2,843
pituitary cancer 3 | 1,972
Colonic Neoplasms 2 | 142
Creatine phosphokinase serum increased 2 | 110
Elevated creatine kinase 2 | 110
Hemoglobin low 2 | 124
Myopathy 2 | 185
Neuropathy 2 | 261
Vomiting 2 | 116

Tissue

Digestive Tract 26 | 17,369
Skin and soft tissues 26 | 17,230
Endocrine System 25 | 18,159
Female tissues 25 | 17,400
Liver and Pancreas 25 | 16,750
Male tissues 25 | 17,142
Urinary Tract 24 | 16,678
Blood and immune system 21 | 16,909
Nervous System 21 | 16,725
Respiratory system 21 | 16,393
Cardiovascular System 18 | 15,192

Target Family

Non-IDG 11 | 12,091
Enzyme 8 | 4,145
Nuclear Receptor 3 | 48
Kinase 2 | 634
Transcription Factor 1 | 1,400
Transporter 1 | 473

WikiPathways Pathway

PPAR Alpha Pathway 26 | 26
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytochrome P450 4A11 CYP4A11 Tbio Non-IDG -1.97180 93.7 142
Apolipoprotein A-V APOA5 Tbio Non-IDG -2.58826 425.0 481
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM Tbio Enzyme -2.01557 101.4 321
Cholesterol 7-alpha-monooxygenase CYP7A1 Tbio Enzyme -2.70498 494.6 94
Peroxisomal bifunctional enzyme EHHADH Tbio Non-IDG -2.05616 109.3 204
Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 Tchem Enzyme -2.28515 186.9 359
Acyl-CoA-binding protein DBI Tbio Non-IDG -2.37374 248.4 232
Long-chain fatty acid transport protein 1 SLC27A1 Tchem Transporter -2.18464 151.5 79
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase CYP8B1 Tbio Enzyme -1.65191 40.5 121
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.11278 12358.0 2705