Development Level

Tbio 202 | 11,445
Tchem 71 | 1,598
Tclin 56 | 613
Tdark 9 | 6,588

Collection

RFA-RM-18-021 2 | 328
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 19 | 979
preweaning lethality, incomple... 16 | 499
enlarged heart 8 | 210
abnormal bone structure 7 | 187
embryonic lethality prior to t... 7 | 278
abnormal behavior 6 | 298
abnormal embryo size 6 | 220
decreased total body fat amoun... 5 | 207
increased mean corpuscular vol... 5 | 92
increased total body fat amoun... 5 | 134
male infertility 5 | 123
abnormal lens morphology 4 | 81
cataract 4 | 92
decreased body weight 4 | 161
decreased circulating glucose ... 4 | 126
decreased lean body mass 4 | 135
decreased lymphocyte cell numb... 4 | 83
enlarged spleen 4 | 41
hypoactivity 4 | 132
impaired glucose tolerance 4 | 75
increased circulating alkaline... 4 | 122
increased circulating choleste... 4 | 66
increased mean corpuscular hem... 4 | 96
thrombocytopenia 4 | 56
abnormal cornea morphology 3 | 31
abnormal retina morphology 3 | 71
abnormal seminal vesicle morph... 3 | 114
abnormal sleep behavior 3 | 70
decreased bone mineral content 3 | 151
decreased erythrocyte cell num... 3 | 62
decreased grip strength 3 | 116
decreased heart weight 3 | 27
decreased hematocrit 3 | 46
decreased leukocyte cell numbe... 3 | 73
decreased vertical activity 3 | 208
female infertility 3 | 60
impaired pupillary reflex 3 | 26
improved glucose tolerance 3 | 79
increased bone mineral content 3 | 108
increased circulating triglyce... 3 | 42
increased fasted circulating g... 3 | 76
increased leukocyte cell numbe... 3 | 47
increased neutrophil cell numb... 3 | 46
increased startle reflex 3 | 112
persistence of hyaloid vascula... 3 | 33
short tibia 3 | 97
small superior vagus ganglion 3 | 74
abnormal femur morphology 2 | 14
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal lung morphology 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal skin morphology 2 | 50
abnormal spleen morphology 2 | 55
abnormal vibrissa morphology 2 | 25
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 38
decreased circulating amylase ... 2 | 28
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating insulin ... 2 | 76
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased hemoglobin content 2 | 68
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular hem... 2 | 31
decreased mean corpuscular vol... 2 | 79
decreased mean platelet volume 2 | 25
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
embryonic lethality prior to o... 2 | 239
enlarged lymph nodes 2 | 37
enlarged uterus 2 | 11
hemorrhage 2 | 23
hyperactivity 2 | 148
increased circulating HDL chol... 2 | 80
increased circulating LDL chol... 2 | 13
increased circulating calcium ... 2 | 34
increased circulating sodium l... 2 | 71
increased heart weight 2 | 62
increased hematocrit 2 | 46
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 36
increased mean platelet volume 2 | 45
increased or absent threshold ... 2 | 101
limb grasping 2 | 41
tremors 2 | 39
abnormal body wall morphology 1 | 9
abnormal ear morphology 1 | 9
abnormal optic disc morphology 1 | 10
abnormal vocalization 1 | 21
decreased circulating bilirubi... 1 | 19
decreased eosinophil cell numb... 1 | 24
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating phosphat... 1 | 26
increased eosinophil cell numb... 1 | 11
iris synechia 1 | 3

Disease

Carcinoma 246 | 11,493
ovarian cancer 194 | 8,520
Cancer 186 | 2,499
osteosarcoma 163 | 7,950
psoriasis 163 | 6,694
glioblastoma 160 | 5,792
lung cancer 148 | 4,740
medulloblastoma, large-cell 146 | 6,241
Breast cancer 129 | 3,578
atypical teratoid / rhabdoid tumor 123 | 5,112
malignant mesothelioma 111 | 3,232
ependymoma 108 | 4,679
Astrocytoma, Pilocytic 98 | 3,081
group 3 medulloblastoma 93 | 4,104
invasive ductal carcinoma 92 | 2,951
adult high grade glioma 90 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 90 | 3,291
lung carcinoma 87 | 2,843
Kidney cancer 86 | 2,613
non-small cell lung cancer 85 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 84 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 82 | 2,989
lung adenocarcinoma 81 | 2,716
pancreatic cancer 79 | 2,398
interstitial cystitis 78 | 2,312
diabetes mellitus 77 | 1,728
oligodendroglioma 74 | 2,850
primitive neuroectodermal tumor 68 | 3,035
ulcerative colitis 67 | 1,819
subependymal giant cell astrocytoma 66 | 2,287
Autosomal recessive predisposition 65 | 1,442
breast carcinoma 63 | 1,638
Schizophrenia 62 | 1,160
pituitary cancer 60 | 1,972
cystic fibrosis 57 | 1,696
astrocytic glioma 56 | 2,597
ductal carcinoma in situ 56 | 1,745
tuberculosis 54 | 2,010
group 4 medulloblastoma 51 | 1,855
Breast Neoplasms 48 | 445
Mammary Neoplasms 48 | 425
pancreatic ductal adenocarcinoma liver metastasis 46 | 1,962
Melanoma 45 | 711
adrenocortical carcinoma 45 | 1,428
colon cancer 45 | 1,478
Liver Cirrhosis, Experimental 43 | 769
Prostatic Neoplasms 43 | 495
Rheumatoid arthritis 42 | 1,191
Epilepsy 38 | 792
Pick disease 38 | 1,894
Seizures 38 | 596
juvenile dermatomyositis 38 | 1,187
Depressive disorder 37 | 409
Obesity 37 | 678
nasopharyngeal carcinoma 37 | 1,058
Intellectual disability 35 | 1,016
Anemia 34 | 365
gastric carcinoma 34 | 807
primary pancreatic ductal adenocarcinoma 34 | 1,109
Bipolar Disorder 33 | 666
Liver carcinoma 33 | 240
Multiple myeloma 33 | 1,332
Vascular disease 33 | 319
astrocytoma 33 | 1,146
Carcinoma, Hepatocellular 32 | 228
Kidney disease 32 | 430
Liver cancer 32 | 604
Short stature 32 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 32 | 510
cutaneous lupus erythematosus 32 | 1,057
Duchenne muscular dystrophy 31 | 601
Multiple Sclerosis 31 | 540
Renal Cell Carcinoma 31 | 214
Stomach Neoplasms 31 | 300
Hypertension 30 | 396
Lung Neoplasms 30 | 232
Skin cancer 30 | 469
non-small cell lung carcinoma 30 | 317
Alzheimer's disease 29 | 658
Neoplasm Metastasis 29 | 168
acute quadriplegic myopathy 29 | 1,158
pediatric high grade glioma 29 | 1,064
Atopic dermatitis 28 | 952
Mental Depression 28 | 333
Autistic Disorder 27 | 364
Dull intelligence 27 | 645
Low intelligence 27 | 645
Mental Retardation 27 | 645
Mental deficiency 27 | 645
Poor school performance 27 | 645
Asthma 26 | 385
Cognitive delay 26 | 608
Global developmental delay 26 | 608
Hypertensive disease 26 | 292
Hypoplastic mandible condyle 26 | 275
Mandibular hypoplasia 26 | 275
Mental and motor retardation 26 | 608
Micrognathism 26 | 275
Orbital separation excessive 25 | 244
dermatomyositis 25 | 966

Tissue

Endocrine System 323 | 18,159
Digestive Tract 320 | 17,369
Blood and immune system 318 | 16,909
Female tissues 317 | 17,400
Skin and soft tissues 315 | 17,230
Liver and Pancreas 312 | 16,750
Male tissues 312 | 17,142
Urinary Tract 309 | 16,678
Nervous System 306 | 16,725
Respiratory system 305 | 16,393
Cardiovascular System 292 | 15,192

Target Family

Non-IDG 208 | 12,091
Kinase 62 | 634
Enzyme 42 | 4,145
Transcription Factor 17 | 1,400
GPCR 9 | 408

WikiPathways Pathway

PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Collagen alpha-1(IV) chain COL4A1 Tbio Non-IDG -2.28595 186.9 391
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Proteinase-activated receptor 1 F2R Tclin GPCR -2.78393 551.0 453
Ephrin-A3 EFNA3 Tbio Non-IDG -1.53049 26.8 219
Ephrin-A4 EFNA4 Tbio Non-IDG -1.23647 17.4 213
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 GNG10 Tdark Non-IDG 0.16 0.62 18
Beta-nerve growth factor NGF Tchem Non-IDG -4.01592 10936.7 735
Vascular endothelial growth factor receptor 1 FLT1 Tclin Kinase -3.38913 2189.4 953