Development Level

Tbio 15 | 11,445
Tchem 12 | 1,598
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
increased mean corpuscular hem... 3 | 96
decreased circulating creatini... 2 | 39
embryonic lethality prior to t... 2 | 278
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating bilirubi... 1 | 19
decreased erythrocyte cell num... 1 | 62
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
hypoactivity 1 | 132
increased circulating LDL chol... 1 | 13
increased circulating glucose ... 1 | 24
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
male infertility 1 | 123
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

Carcinoma 27 | 11,493
Cancer 23 | 2,499
ovarian cancer 21 | 8,520
lung cancer 15 | 4,740
Kidney cancer 14 | 2,613
medulloblastoma, large-cell 14 | 6,241
osteosarcoma 14 | 7,950
psoriasis 14 | 6,694
atypical teratoid / rhabdoid tumor 13 | 5,112
Breast cancer 12 | 3,578
adult high grade glioma 11 | 3,801
glioblastoma 11 | 5,792
Epilepsy 9 | 792
Breast Neoplasms 8 | 445
Intellectual disability 8 | 1,016
Mammary Neoplasms 8 | 425
Renal Cell Carcinoma 8 | 214
Schizophrenia 8 | 1,160
Seizures 8 | 596
diabetes mellitus 8 | 1,728
group 3 medulloblastoma 8 | 4,104
juvenile dermatomyositis 8 | 1,187
Cognitive delay 7 | 608
Dull intelligence 7 | 645
Endometrial cancer 7 | 311
Fibrous skin tumor of tuberous sclerosis 7 | 18
Frontal bossing 7 | 157
Global developmental delay 7 | 608
Hypoplastic mandible condyle 7 | 275
Low intelligence 7 | 645
Mandibular hypoplasia 7 | 275
Mental Retardation 7 | 645
Mental and motor retardation 7 | 608
Mental deficiency 7 | 645
Micrognathism 7 | 275
Orbital separation excessive 7 | 244
Poor school performance 7 | 645
Prostatic Neoplasms 7 | 495
Sebaceous adenoma 7 | 26
Stomach Neoplasms 7 | 300
Vascular disease 7 | 319
breast carcinoma 7 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
subependymal giant cell astrocytoma 7 | 2,287
Adenoma 6 | 167
Big calvaria 6 | 147
Byzanthine arch palate 6 | 194
Carcinoma, Hepatocellular 6 | 228
Concave bridge of nose 6 | 195
Depressed nasal bridge 6 | 195
Depressed nasal root/bridge 6 | 195
Downward slant of palpebral fissure 6 | 158
Hemangioma, Cavernous 6 | 20
Increased head circumference 6 | 147
Increased size of cranium 6 | 147
Increased size of skull 6 | 147
Liver carcinoma 6 | 240
Lung Neoplasms 6 | 232
Melanocytic nevus 6 | 43
Noncancerous mole 6 | 28
Obesity 6 | 678
Ovarian Neoplasms 6 | 102
Parkinson's disease 6 | 392
Pick disease 6 | 1,894
Squamous cell carcinoma 6 | 129
Upper respiratory tract disease 6 | 15
dermatomyositis 6 | 966
group 4 medulloblastoma 6 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
invasive ductal carcinoma 6 | 2,951
lung adenocarcinoma 6 | 2,716
pancreatic cancer 6 | 2,398
Acquired scoliosis 5 | 281
Adenocarcinoma 5 | 122
Autistic Disorder 5 | 364
Autosomal recessive predisposition 5 | 1,442
Blepharoptosis 5 | 231
Carcinoma, Squamous Cell 5 | 110
Curvature of spine 5 | 282
DOID:2627 5 | 94
Depressive disorder 5 | 409
Diarrhea 5 | 253
Hemangioma 5 | 69
Irregular hyperpigmentation 5 | 33
Isolated cases 5 | 72
Leukemia, Myeloid, Acute 5 | 105
Melanoma 5 | 711
Muscle hypotonia 5 | 571
Muscular atrophy 5 | 71
Myopia 5 | 176
Pectus excavatum 5 | 100
Rheumatoid arthritis 5 | 1,191
Telecanthus 5 | 62
acute quadriplegic myopathy 5 | 1,158
astrocytic glioma 5 | 2,597
astrocytoma 5 | 1,146
non-small cell lung cancer 5 | 2,890
oligodendroglioma 5 | 2,850
ovarian neoplasm 5 | 99

Tissue

Blood and immune system 30 | 16,909
Cardiovascular System 30 | 15,192
Digestive Tract 30 | 17,369
Endocrine System 30 | 18,159
Female tissues 30 | 17,400
Liver and Pancreas 30 | 16,750
Male tissues 30 | 17,142
Nervous System 30 | 16,725
Respiratory system 30 | 16,393
Skin and soft tissues 30 | 17,230
Urinary Tract 30 | 16,678

Target Family

Enzyme 9 | 4,145
Kinase 9 | 634
Non-IDG 8 | 12,091
Transcription Factor 4 | 1,400

WikiPathways Pathway

PI3K-AKT-mTOR signaling pathwa... 30 | 30
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
Forkhead box protein O4 FOXO4 Tbio Transcription Factor -2.43923 278.0 720
Bcl2-associated agonist of cell death BAD Tchem Non-IDG -2.08893 103.4 2565
Nitric oxide synthase, endothelial NOS3 Tchem Enzyme -3.96497 9525.3 1195
Growth factor receptor-bound protein 10 GRB10 Tbio Non-IDG -1.98746 111.0 315