Development Level

Tchem 23 | 1,598
Tbio 11 | 11,445
Tclin 5 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal bone structure 2 | 187
abnormal retina morphology 2 | 71
embryonic lethality prior to o... 2 | 239
increased neutrophil cell numb... 2 | 46
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal coat appearance 1 | 31
abnormal cranium morphology 1 | 36
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
hypoactivity 1 | 132
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating triglyce... 1 | 42
increased lymphocyte cell numb... 1 | 32
increased spleen weight 1 | 10
short tibia 1 | 97
thin ventricular wall 1 | 24

Disease

Cancer 34 | 2,499
Carcinoma 33 | 11,493
ovarian cancer 29 | 8,520
osteosarcoma 22 | 7,950
lung cancer 21 | 4,740
glioblastoma 19 | 5,792
atypical teratoid / rhabdoid tumor 16 | 5,112
medulloblastoma, large-cell 16 | 6,241
Breast cancer 15 | 3,578
Kidney cancer 13 | 2,613
ependymoma 13 | 4,679
psoriasis 13 | 6,694
group 4 medulloblastoma 12 | 1,855
pancreatic cancer 12 | 2,398
Breast Neoplasms 11 | 445
Mammary Neoplasms 11 | 425
malignant mesothelioma 11 | 3,232
Arthritis 10 | 290
Multiple myeloma 10 | 1,332
Rheumatoid arthritis 10 | 1,191
Schizophrenia 10 | 1,160
diabetes mellitus 10 | 1,728
group 3 medulloblastoma 10 | 4,104
Heart disease 9 | 306
Pick disease 9 | 1,894
Short stature 9 | 531
Vascular disease 9 | 319
adult high grade glioma 9 | 3,801
astrocytic glioma 9 | 2,597
astrocytoma 9 | 1,146
cystic fibrosis 9 | 1,696
lung adenocarcinoma 9 | 2,716
oligodendroglioma 9 | 2,850
subependymal giant cell astrocytoma 9 | 2,287
Depressive disorder 8 | 409
Kidney disease 8 | 430
Stomach Neoplasms 8 | 300
breast carcinoma 8 | 1,638
pituitary cancer 8 | 1,972
primitive neuroectodermal tumor 8 | 3,035
Asthma 7 | 385
Astrocytoma, Pilocytic 7 | 3,081
Blepharoptosis 7 | 231
Brain Ischemia 7 | 110
Carcinoma, Hepatocellular 7 | 228
Carcinoma, Squamous Cell 7 | 110
Delayed bone age 7 | 136
Hypoplastic mandible condyle 7 | 275
Liver carcinoma 7 | 240
Lung Neoplasms 7 | 232
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Noonan syndrome 7 | 34
lung carcinoma 7 | 2,843
non-small cell lung cancer 7 | 2,890
pancreatic carcinoma 7 | 562
Animal Mammary Neoplasms 6 | 136
Atherosclerosis 6 | 291
Byzanthine arch palate 6 | 194
Cell Transformation, Neoplastic 6 | 97
Cryptorchidism 6 | 296
Disease Models, Animal 6 | 155
Downward slant of palpebral fissure 6 | 158
Epilepsy 6 | 792
Fetal Growth Retardation 6 | 189
Hepatomegaly 6 | 285
Hypertrophic Cardiomyopathy 6 | 117
Infant, Small for Gestational Age 6 | 176
Intrauterine retardation 6 | 176
Liver Cirrhosis, Experimental 6 | 769
Lung disease 6 | 142
Mammary Neoplasms, Animal 6 | 136
Mammary Neoplasms, Experimental 6 | 154
Orbital separation excessive 6 | 244
Parkinson's disease 6 | 392
Squamous cell carcinoma 6 | 129
colon cancer 6 | 1,478
dermatomyositis 6 | 966
interstitial cystitis 6 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
invasive ductal carcinoma 6 | 2,951
juvenile dermatomyositis 6 | 1,187
tuberculosis 6 | 2,010
Acquired scoliosis 5 | 281
Alzheimer's disease 5 | 658
Broad flat nasal bridge 5 | 236
Congenital Epicanthus 5 | 177
Curvature of spine 5 | 282
Dysarthria 5 | 192
Eye disease 5 | 62
Frontal bossing 5 | 157
Inflammatory bowel disease 5 | 151
Mental Depression 5 | 333
Nasal bridge wide 5 | 236
Neoplasm Invasiveness 5 | 161
Seizures 5 | 596
Strabismus 5 | 270
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
primary pancreatic ductal adenocarcinoma 5 | 1,109

Tissue

Blood and immune system 39 | 16,909
Cardiovascular System 39 | 15,192
Digestive Tract 39 | 17,369
Endocrine System 39 | 18,159
Female tissues 39 | 17,400
Liver and Pancreas 39 | 16,750
Male tissues 39 | 17,142
Nervous System 39 | 16,725
Respiratory system 39 | 16,393
Skin and soft tissues 39 | 17,230
Urinary Tract 39 | 16,678

Target Family

Kinase 13 | 634
Non-IDG 11 | 12,091
Enzyme 9 | 4,145
Transcription Factor 6 | 1,400

WikiPathways Pathway

PDGF Pathway 39 | 39
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998
ETS domain-containing protein Elk-1 ELK1 Tbio Transcription Factor -0.51976 3.02 941
Serum response factor SRF Tbio Transcription Factor -2.94583 721.8 474
Cytosolic phospholipase A2 PLA2G4A Tchem Enzyme -2.68316 506.7 274
Cytochrome c oxidase subunit 2 MT-CO2 Tchem Enzyme -2.96018 880.4 127
Mitogen-activated protein kinase kinase kinase 1 MAP3K1 Tchem Kinase -2.12399 119.4 334
Platelet-derived growth factor subunit A PDGFA Tchem Non-IDG -2.74845 537.8 341