Development Level

Tbio 17 | 11,445
Tchem 9 | 1,598
Tclin 4 | 613

IMPC Phenotype

decreased circulating amylase ... 2 | 28
decreased circulating insulin ... 2 | 76
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal lens morphology 1 | 81
abnormal skin condition 1 | 6
abnormal testis morphology 1 | 43
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
enlarged epididymis 1 | 31
impaired righting response 1 | 26
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased thermal nociceptive ... 1 | 9
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
preweaning lethality, complete... 1 | 979
small testis 1 | 58
stereotypic behavior 1 | 3
trunk curl 1 | 16

Disease

Cancer 20 | 2,499
psoriasis 20 | 6,694
Carcinoma 19 | 11,493
ovarian cancer 19 | 8,520
glioblastoma 16 | 5,792
lung cancer 16 | 4,740
invasive ductal carcinoma 13 | 2,951
non-small cell lung cancer 13 | 2,890
Hypertension 12 | 396
Schizophrenia 12 | 1,160
diabetes mellitus 12 | 1,728
lung adenocarcinoma 12 | 2,716
lung carcinoma 12 | 2,843
Hypertensive disease 11 | 292
osteosarcoma 11 | 7,950
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Toxic encephalopathy 10 | 141
acute quadriplegic myopathy 10 | 1,158
interstitial cystitis 10 | 2,312
Breast cancer 9 | 3,578
Chemical and Drug Induced Liver Injury 9 | 195
Contact Dermatitis 9 | 81
Dermatitis, Contact 9 | 71
Diabetes Mellitus, Experimental 9 | 108
Vascular disease 9 | 319
ependymoma 9 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
malignant mesothelioma 9 | 3,232
Alzheimer's disease 8 | 658
Heart failure 8 | 162
Obesity 8 | 678
atypical teratoid / rhabdoid tumor 8 | 5,112
medulloblastoma, large-cell 8 | 6,241
pancreatic cancer 8 | 2,398
tuberculosis 8 | 2,010
Atherosclerosis 7 | 291
Autosomal recessive predisposition 7 | 1,442
Breast Neoplasms 7 | 445
Diabetes Mellitus, Non-Insulin-Dependent 7 | 145
Diabetes Mellitus, Type 2 7 | 142
Hyperglycemia 7 | 137
Lung Neoplasms 7 | 232
Mammary Neoplasms 7 | 425
Parkinson's disease 7 | 392
Prostatic Neoplasms 7 | 495
Reperfusion Injury 7 | 86
breast carcinoma 7 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
pituitary cancer 7 | 1,972
Brain Ischemia 6 | 110
Cell Transformation, Neoplastic 6 | 97
Down syndrome 6 | 499
Endometriosis 6 | 540
Hyperthyroidism 6 | 53
Kidney disease 6 | 430
Mental Depression 6 | 333
Multiple myeloma 6 | 1,332
Myocardial Ischemia 6 | 169
Neurodegenerative Disorders 6 | 79
Parkinson Disease 6 | 64
Pulmonary Fibrosis 6 | 106
adult high grade glioma 6 | 3,801
group 3 medulloblastoma 6 | 4,104
ulcerative colitis 6 | 1,819
Anemia 5 | 365
Astrocytoma, Pilocytic 5 | 3,081
Carcinoma, Non-Small-Cell Lung 5 | 107
Chronic Obstructive Airway Disease 5 | 37
Depressive disorder 5 | 409
Epilepsy 5 | 792
Fatty Liver 5 | 70
Kidney Failure, Chronic 5 | 46
Liver Cirrhosis, Experimental 5 | 769
Major Depressive Disorder 5 | 301
Necrosis 5 | 53
Neoplastic Cell Transformation 5 | 89
Neurodegenerative Diseases 5 | 38
Neurodegenerative disease 5 | 414
Rheumatoid arthritis 5 | 1,191
astrocytoma 5 | 1,146
cystic fibrosis 5 | 1,696
ductal carcinoma in situ 5 | 1,745
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
non-small cell lung carcinoma 5 | 317
primary pancreatic ductal adenocarcinoma 5 | 1,109
primitive neuroectodermal tumor 5 | 3,035
subependymal giant cell astrocytoma 5 | 2,287
Bipolar Disorder 4 | 666
Cholestasis 4 | 155
Hepatomegaly 4 | 285
Liver carcinoma 4 | 240
Status Epilepticus 4 | 98
Waldenstrons macroglobulinemia 4 | 765
adrenocortical carcinoma 4 | 1,428
colon cancer 4 | 1,478
cutaneous lupus erythematosus 4 | 1,057
esophageal adenocarcinoma 4 | 737
fibroadenoma 4 | 559
nephrosclerosis 4 | 333

Tissue

Blood and immune system 29 | 16,909
Digestive Tract 29 | 17,369
Endocrine System 29 | 18,159
Female tissues 29 | 17,400
Liver and Pancreas 29 | 16,750
Male tissues 29 | 17,142
Respiratory system 29 | 16,393
Skin and soft tissues 29 | 17,230
Urinary Tract 29 | 16,678
Nervous System 28 | 16,725
Cardiovascular System 26 | 15,192

Target Family

Enzyme 18 | 4,145
Transcription Factor 6 | 1,400
Non-IDG 4 | 12,091
Kinase 2 | 634

WikiPathways Pathway

Oxidative Stress 30 | 30
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glutathione S-transferase theta-2 GSTT2 Tbio Enzyme -1.25193 16.8 0
NAD(P)H dehydrogenase [quinone] 1 NQO1 Tchem Enzyme -3.12097 1326.4 550
Nuclear factor 1 X-type NFIX Tbio Transcription Factor -1.70265 49.7 74
Glutathione reductase, mitochondrial GSR Tclin Enzyme -3.00773 863.8 276
Xanthine dehydrogenase/oxidase XDH Tclin Enzyme -2.69810 506.6 179
Microsomal glutathione S-transferase 1 MGST1 Tbio Enzyme -2.30082 197.5 146
Thioredoxin reductase 1, cytoplasmic TXNRD1 Tclin Enzyme -2.28524 208.2 308
Metallothionein-1X MT1X Tbio Non-IDG -1.28887 20.1 17
Extracellular superoxide dismutase [Cu-Zn] SOD3 Tbio Enzyme -2.66624 502.0 363
Glutathione peroxidase 3 GPX3 Tbio Enzyme -2.68271 472.3 196