Development Level

Tbio 20 | 11,445
Tclin 8 | 613
Tchem 4 | 1,598

IMPC Phenotype

male infertility 3 | 123
abnormal embryo size 2 | 220
decreased bone mineral content 2 | 151
female infertility 2 | 60
increased leukocyte cell numbe... 2 | 47
preweaning lethality, incomple... 2 | 499
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal male genitalia morpho... 1 | 3
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
absent seminal vesicle 1 | 4
absent startle reflex 1 | 24
decreased body length 1 | 101
decreased brain size 1 | 4
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
fusion of vertebral arches 1 | 7
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased circulating alkaline... 1 | 122
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased lymphocyte cell numb... 1 | 32
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
polysyndactyly 1 | 2
short tibia 1 | 97
small heart 1 | 10
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19
small stomach 1 | 3
small testis 1 | 58
small thymus 1 | 16
small uterus 1 | 3
thin ventricular wall 1 | 24
vertebral transformation 1 | 12

Disease

Carcinoma 24 | 11,493
ovarian cancer 22 | 8,520
psoriasis 17 | 6,694
Cancer 14 | 2,499
Infertility 13 | 188
lung cancer 12 | 4,740
Breast cancer 11 | 3,578
Premature ovarian failure 11 | 65
glioblastoma 11 | 5,792
malignant mesothelioma 11 | 3,232
Autosomal recessive predisposition 10 | 1,442
osteosarcoma 10 | 7,950
Endometriosis 9 | 540
Prostatic Neoplasms 9 | 495
medulloblastoma, large-cell 9 | 6,241
Breast Neoplasms 8 | 445
Kidney cancer 8 | 2,613
Male infertility 8 | 206
Mammary Neoplasms 8 | 425
group 3 medulloblastoma 8 | 4,104
ulcerative colitis 8 | 1,819
Amenorrhea 7 | 58
Schizophrenia 7 | 1,160
interstitial cystitis 7 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
invasive ductal carcinoma 7 | 2,951
lung carcinoma 7 | 2,843
oligodendroglioma 7 | 2,850
pituitary cancer 7 | 1,972
Osteoporosis 6 | 363
Polycystic ovary syndrome 6 | 360
atypical teratoid / rhabdoid tumor 6 | 5,112
colon cancer 6 | 1,478
ependymoma 6 | 4,679
pancreatic cancer 6 | 2,398
Chronic Lymphocytic Leukemia 5 | 262
Obesity 5 | 678
Ovarian dysfunction 5 | 18
Short stature 5 | 531
astrocytic glioma 5 | 2,597
breast carcinoma 5 | 1,638
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
lung adenocarcinoma 5 | 2,716
subependymal giant cell astrocytoma 5 | 2,287
Adenoma 4 | 167
Animal Mammary Neoplasms 4 | 136
Anovulation 4 | 21
Carcinoma, Hepatocellular 4 | 228
Epilepsy 4 | 792
Female infertility 4 | 30
Hypogonadism 4 | 173
Liver carcinoma 4 | 240
Mammary Neoplasms, Animal 4 | 136
Mammary Neoplasms, Experimental 4 | 154
Ovarian Neoplasms 4 | 102
Pick disease 4 | 1,894
Primary hypogonadism 4 | 37
Primary physiologic amenorrhea 4 | 55
Seizures 4 | 596
Stomach Neoplasms 4 | 300
acute myeloid leukemia 4 | 783
astrocytoma 4 | 1,146
cystic fibrosis 4 | 1,696
diabetes mellitus 4 | 1,728
nasopharyngeal carcinoma 4 | 1,058
ovarian neoplasm 4 | 99
primitive neuroectodermal tumor 4 | 3,035
tuberculosis 4 | 2,010
Alzheimer's disease 3 | 658
Bladder Neoplasm 3 | 112
Carcinoma, Transitional Cell 3 | 32
Cocaine-Related Disorders 3 | 92
Coronary artery disease 3 | 268
Delayed bone age 3 | 136
Down syndrome 3 | 499
Endometrial Neoplasms 3 | 55
Endometrial cancer 3 | 311
Generalized osteopenia 3 | 99
Hair shaft abnormalities 3 | 30
Infertility, Female 3 | 28
Liver Cirrhosis, Experimental 3 | 769
Melanoma 3 | 711
Mesothelioma 3 | 38
Multiple Sclerosis 3 | 540
Neurodegenerative disease 3 | 414
Osteopenia 3 | 99
Postmenopausal osteoporosis 3 | 19
Rheumatoid arthritis 3 | 1,191
Urinary Bladder Neoplasms 3 | 114
Vascular disease 3 | 319
acute quadriplegic myopathy 3 | 1,158
adult high grade glioma 3 | 3,801
gastric carcinoma 3 | 807
hair abnormalities (non-specific) 3 | 30
medulloblastoma 3 | 720
non-small cell lung cancer 3 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
primary pancreatic ductal adenocarcinoma 3 | 1,109

Tissue

Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Digestive Tract 31 | 17,369
Skin and soft tissues 31 | 17,230
Blood and immune system 29 | 16,909
Liver and Pancreas 29 | 16,750
Urinary Tract 29 | 16,678
Male tissues 28 | 17,142
Respiratory system 28 | 16,393
Cardiovascular System 27 | 15,192
Nervous System 27 | 16,725

Target Family

Non-IDG 14 | 12,091
Transcription Factor 5 | 1,400
Nuclear Receptor 4 | 48
Enzyme 3 | 4,145
GPCR 3 | 408
Kinase 3 | 634

WikiPathways Pathway

Ovarian Infertility Genes 32 | 32
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nesprin-2 SYNE2 Tbio Non-IDG -2.62747 380.6 39
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
Gap junction alpha-4 protein GJA4 Tbio Non-IDG -2.27043 180.6 231
Nuclear receptor-interacting protein 1 NRIP1 Tbio Non-IDG -2.21323 183.8 155
Factor in the germline alpha FIGLA Tbio Transcription Factor -1.53789 36.4 71
Bone morphogenetic protein receptor type-1B BMPR1B Tchem Kinase -2.00303 86.8 498
Estrogen receptor beta ESR2 Tclin Nuclear Receptor -3.57388 3765.2 1096
Vitamin D3 receptor VDR Tclin Nuclear Receptor -3.62166 3805.7 575
Deleted in azoospermia-like DAZL Tbio Non-IDG -2.17621 156.2 191
TATA-box-binding protein TBP Tbio Non-IDG -3.27246 1844.4 387