Development Level

Tchem 10 | 1,598
Tclin 2 | 613
Tbio 1 | 11,445

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal cornea morphology 1 | 31
abnormal skin condition 1 | 6
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating sodium l... 1 | 22
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased leukocyte cell numbe... 1 | 47
increased thermal nociceptive ... 1 | 9
preweaning lethality, complete... 1 | 979
short tibia 1 | 97

Disease

Cancer 12 | 2,499
Carcinoma 10 | 11,493
glioblastoma 10 | 5,792
ovarian cancer 8 | 8,520
Brain Ischemia 7 | 110
Arthritis 6 | 290
Breast cancer 6 | 3,578
Kidney cancer 6 | 2,613
Schizophrenia 6 | 1,160
diabetes mellitus 6 | 1,728
tuberculosis 6 | 2,010
Astrocytoma, Pilocytic 5 | 3,081
Cerebral Hemorrhage 5 | 42
Neoplasm Invasiveness 5 | 161
Neoplasm Metastasis 5 | 168
atypical teratoid / rhabdoid tumor 5 | 5,112
ependymoma 5 | 4,679
non-small cell lung cancer 5 | 2,890
osteosarcoma 5 | 7,950
psoriasis 5 | 6,694
Autosomal recessive predisposition 4 | 1,442
Cholestasis, Extrahepatic 4 | 25
Hypertension 4 | 396
Liver Cirrhosis, Experimental 4 | 769
Multiple Sclerosis 4 | 540
Obesity 4 | 678
Prostatic Neoplasms 4 | 495
colon cancer 4 | 1,478
interstitial cystitis 4 | 2,312
lung cancer 4 | 4,740
medulloblastoma, large-cell 4 | 6,241
pancreatic cancer 4 | 2,398
primitive neuroectodermal tumor 4 | 3,035
Adenocarcinoma 3 | 122
Alzheimer's disease 3 | 658
Asthma 3 | 385
Breast Neoplasms 3 | 445
Carcinoma, Squamous Cell 3 | 110
Cell Transformation, Neoplastic 3 | 97
Cerebrovascular accident 3 | 63
Cerebrovascular disease 3 | 238
Colonic Neoplasms 3 | 142
Coronary artery disease 3 | 268
Disease Models, Animal 3 | 155
Gliosis 3 | 56
Heart disease 3 | 306
Kidney disease 3 | 430
Liver Neoplasms, Experimental 3 | 59
Lung Neoplasms 3 | 232
Mammary Neoplasms 3 | 425
Multiple myeloma 3 | 1,332
Myocardial Infarction 3 | 151
Neoplastic Cell Transformation 3 | 89
Osteoporosis 3 | 363
Pneumonia 3 | 174
Premature Birth 3 | 77
Reperfusion Injury 3 | 86
Sepsis 3 | 24
Short stature 3 | 531
Squamous cell carcinoma 3 | 129
Stomach Neoplasms 3 | 300
Stroke 3 | 33
Substance Withdrawal Syndrome 3 | 55
Vascular disease 3 | 319
astrocytoma 3 | 1,146
esophageal adenocarcinoma 3 | 737
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
invasive ductal carcinoma 3 | 2,951
lung adenocarcinoma 3 | 2,716
malignant mesothelioma 3 | 3,232
nasopharyngeal carcinoma 3 | 1,058
oligodendroglioma 3 | 2,850
ulcerative colitis 3 | 1,819
Alcoholic Intoxication, Chronic 2 | 289
Atherosclerosis 2 | 291
Cardiomyopathies 2 | 110
Cocaine-Related Disorders 2 | 92
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Ecchymosis 2 | 66
Eye disease 2 | 62
Failure to gain weight 2 | 365
Female infertility 2 | 30
Hyperalgesia 2 | 83
Infertility, Female 2 | 28
Inflammatory bowel disease 2 | 151
Intracranial Hemorrhages 2 | 16
Liver Cirrhosis 2 | 181
Liver diseases 2 | 87
Lung disease 2 | 142
Nerve Degeneration 2 | 121
Pancreatic Neoplasm 2 | 85
Pancreatic Neoplasms 2 | 85
Pediatric failure to thrive 2 | 365
Premature birth of newborn 2 | 67
Purpura 2 | 43
Severe combined immunodeficiency 2 | 51
Thrombocytopenia 2 | 197
pediatric high grade glioma 2 | 1,064

Tissue

Blood and immune system 13 | 16,909
Cardiovascular System 13 | 15,192
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678

Target Family

Kinase 6 | 634
Non-IDG 3 | 12,091
Enzyme 2 | 4,145
Transcription Factor 2 | 1,400

WikiPathways Pathway

Osteopontin Signaling 13 | 13
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440
Matrix metalloproteinase-9 MMP9 Tchem Enzyme -3.96102 8811.6 1442
Inhibitor of nuclear factor kappa-B kinase subunit alpha CHUK Tchem Kinase -2.36360 203.6 1101
Mitogen-activated protein kinase kinase kinase 14 MAP3K14 Tchem Kinase 0.00000 244
Osteopontin SPP1 Tbio Non-IDG -3.66384 4916.5 1053
Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB Tchem Kinase -2.93125 790.1 1824
Urokinase-type plasminogen activator PLAU Tchem Enzyme -3.22994 1960.2 689
Transcription factor p65 RELA Tchem Transcription Factor -3.00328 988.5 2215