Development Level

Tbio 17 | 11,651
Tchem 7 | 1,388
Tclin 4 | 612
Tdark 1 | 6,593

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 3 | 278
preweaning lethality, incomple... 3 | 499
cataract 2 | 92
abnormal allantois morphology 1 | 8
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal retinal vasculature m... 1 | 27
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating chloride... 1 | 30
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased threshold for audito... 1 | 26
decreased total body fat amoun... 1 | 207
increased anxiety-related resp... 1 | 2
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 23 | 11,493
ovarian cancer 15 | 8,520
medulloblastoma, large-cell 14 | 6,241
psoriasis 14 | 6,694
lung cancer 13 | 4,740
non-small cell lung cancer 13 | 2,890
osteosarcoma 13 | 7,950
Cancer 12 | 2,499
Autosomal recessive predisposition 11 | 1,442
Breast cancer 10 | 3,578
group 3 medulloblastoma 10 | 4,104
Cleft Lip 9 | 141
Kidney cancer 9 | 2,613
adrenocortical carcinoma 9 | 1,428
atypical teratoid / rhabdoid tumor 9 | 5,112
glioblastoma 9 | 5,792
malignant mesothelioma 9 | 3,232
Adverse reaction to drug 8 | 61
Breast Neoplasms 8 | 445
Drug-Related Side Effects and Adverse Reactions 8 | 62
Hyperhomocysteinemia 8 | 37
Mammary Neoplasms 8 | 425
invasive ductal carcinoma 8 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
primitive neuroectodermal tumor 8 | 3,035
Intellectual disability 7 | 1,016
Prostatic Neoplasms 7 | 495
Schizophrenia 7 | 1,160
ependymoma 7 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
lung adenocarcinoma 7 | 2,716
Anemia 6 | 365
Cleft Palate 6 | 271
Cognitive delay 6 | 608
Down syndrome 6 | 499
Dull intelligence 6 | 645
Global developmental delay 6 | 608
Homocystinuria 6 | 21
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental and motor retardation 6 | 608
Mental deficiency 6 | 645
Poor school performance 6 | 645
colon cancer 6 | 1,478
ductal carcinoma in situ 6 | 1,745
oligodendroglioma 6 | 2,850
tuberculosis 6 | 2,010
Anemia, Megaloblastic 5 | 16
Colorectal Neoplasms 5 | 243
Epilepsy 5 | 792
Failure to gain weight 5 | 365
Muscle hypotonia 5 | 571
Nervous System Diseases 5 | 53
Pediatric failure to thrive 5 | 365
Seizures 5 | 596
acute quadriplegic myopathy 5 | 1,158
astrocytic glioma 5 | 2,597
diabetes mellitus 5 | 1,728
interstitial cystitis 5 | 2,312
nasopharyngeal carcinoma 5 | 1,058
nervous system disorder 5 | 53
pancreatic cancer 5 | 2,398
spina bifida 5 | 1,074
ulcerative colitis 5 | 1,819
Adenocarcinoma of lung 4 | 142
Arthritis, Rheumatoid 4 | 174
Astrocytoma, Pilocytic 4 | 3,081
Bipolar Disorder 4 | 666
Cerebral atrophy 4 | 178
Degenerative brain disorder 4 | 100
Depressive disorder 4 | 409
Disease Models, Animal 4 | 155
Lymphoma, Non-Hodgkin 4 | 24
Methylmalonic acidemia 4 | 37
Neural tube defect, folate-sensitive 4 | 4
Rheumatoid arthritis 4 | 1,191
Stomach Neoplasms 4 | 300
Supratentorial atrophy 4 | 94
adult high grade glioma 4 | 3,801
astrocytoma 4 | 1,146
group 4 medulloblastoma 4 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
nephrosclerosis 4 | 333
primary Sjogren syndrome 4 | 735
progressive supranuclear palsy 4 | 676
Atopic dermatitis 3 | 952
Crohn's disease 3 | 321
Infertility, Male 3 | 46
Male infertility 3 | 206
Megaloblastic anemia 3 | 18
Mental Depression 3 | 333
Multiple myeloma 3 | 1,332
Waldenstrons macroglobulinemia 3 | 765
active ulcerative colitis 3 | 764
breast carcinoma 3 | 1,638
dermatomyositis 3 | 966
esophageal adenocarcinoma 3 | 737
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
pituitary cancer 3 | 1,972
subependymal giant cell astrocytoma 3 | 2,287

Tissue

Digestive Tract 28 | 17,369
Endocrine System 28 | 18,159
Female tissues 28 | 17,400
Liver and Pancreas 28 | 16,750
Male tissues 28 | 17,142
Nervous System 28 | 16,725
Skin and soft tissues 28 | 17,230
Urinary Tract 28 | 16,678
Blood and immune system 27 | 16,909
Cardiovascular System 27 | 15,192
Respiratory system 26 | 16,393

Target Family

Enzyme 23 | 4,145
Non-IDG 4 | 12,091
Epigenetic 2 | 242

WikiPathways Pathway

One Carbon Metabolism 29 | 29
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
DNA (cytosine-5)-methyltransferase 3A DNMT3A Tclin Epigenetic -2.91291 722.8 693
S-adenosylmethionine synthase isoform type-1 MAT1A Tbio Enzyme -2.11527 125.3 167
Methionine adenosyltransferase 2 subunit beta MAT2B Tbio Enzyme -1.09522 11.9 158
Monofunctional C1-tetrahydrofolate synthase, mitochondrial MTHFD1L Tbio Enzyme -1.66972 40.2 102
Betaine--homocysteine S-methyltransferase 1 BHMT Tchem Enzyme -2.18155 160.8 309
Glutaredoxin-1 GLRX Tbio Non-IDG -2.65642 453.5 163
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 Tchem Enzyme -1.43089 24.9 131
5-formyltetrahydrofolate cyclo-ligase MTHFS Tbio Enzyme -1.10094 12.8 167
Adenosylhomocysteinase AHCY Tchem Enzyme -2.69517 493.7 257