Development Level

Tbio 24 | 11,651
Tchem 14 | 1,388
Tclin 3 | 612

IMPC Phenotype

abnormal snout morphology 1 | 23
absent testes 1 | 6
decreased circulating glucose ... 1 | 126
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased grip strength 1 | 41
male infertility 1 | 123
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 30 | 11,493
osteosarcoma 21 | 7,950
ovarian cancer 21 | 8,520
psoriasis 20 | 6,694
Cancer 16 | 2,499
glioblastoma 15 | 5,792
lung cancer 15 | 4,740
lung carcinoma 14 | 2,843
Kidney cancer 12 | 2,613
pancreatic cancer 12 | 2,398
Breast cancer 11 | 3,578
adult high grade glioma 11 | 3,801
malignant mesothelioma 11 | 3,232
subependymal giant cell astrocytoma 11 | 2,287
Arthritis 10 | 290
non-small cell lung cancer 10 | 2,890
tuberculosis 10 | 2,010
ulcerative colitis 10 | 1,819
Astrocytoma, Pilocytic 9 | 3,081
cystic fibrosis 9 | 1,696
medulloblastoma, large-cell 9 | 6,241
Muckle-Wells syndrome 8 | 12
invasive ductal carcinoma 8 | 2,951
Inflammatory bowel disease 7 | 151
Liver Cirrhosis, Experimental 7 | 769
Multiple myeloma 7 | 1,332
gastric cancer 7 | 459
interstitial cystitis 7 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
lung adenocarcinoma 7 | 2,716
pancreatic carcinoma 7 | 562
Blau syndrome 6 | 9
Breast Neoplasms 6 | 445
Colitis, Ulcerative 6 | 59
Crohn's disease 6 | 321
Familial cold autoinflammatory syndrome 6 | 10
Kidney disease 6 | 430
Mammary Neoplasms 6 | 425
Melanoma 6 | 711
Rheumatoid arthritis 6 | 1,191
cutaneous lupus erythematosus 6 | 1,057
diabetes mellitus 6 | 1,728
hepatocellular carcinoma 6 | 547
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
juvenile dermatomyositis 6 | 1,187
primary Sjogren syndrome 6 | 735
primary pancreatic ductal adenocarcinoma 6 | 1,109
sarcoidosis 6 | 370
Atherosclerosis 5 | 291
Autosomal recessive predisposition 5 | 1,442
Brain Ischemia 5 | 110
Dermatitis 5 | 157
Hypertension 5 | 396
Myocardial Reperfusion Injury 5 | 37
Obesity 5 | 678
Peritonitis 5 | 43
Pneumonia 5 | 174
Skin cancer 5 | 469
Waldenstrons macroglobulinemia 5 | 765
atypical teratoid / rhabdoid tumor 5 | 5,112
colon cancer 5 | 1,478
ependymoma 5 | 4,679
group 3 medulloblastoma 5 | 4,104
Asthma 4 | 385
Bipolar Disorder 4 | 666
Carcinoma, Hepatocellular 4 | 228
Exanthem 4 | 37
Gout 4 | 104
Hypersensitivity reaction type II disease 4 | 253
Liver carcinoma 4 | 240
Lung Neoplasms 4 | 232
Lung disease 4 | 142
Meningitis 4 | 67
Mevalonic aciduria 4 | 16
Neurodegenerative disease 4 | 414
Salmonellosis 4 | 42
Urticaria 4 | 67
Vascular disease 4 | 319
active Crohn's disease 4 | 922
active ulcerative colitis 4 | 764
astrocytoma 4 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
oligodendroglioma 4 | 2,850
Arthritis, Rheumatoid 3 | 174
Contact Dermatitis 3 | 81
Depressive disorder 3 | 409
Dermatitis, Contact 3 | 71
Eye disease 3 | 62
Mental Depression 3 | 333
Multiple Sclerosis 3 | 540
Reperfusion Injury 3 | 86
Schizophrenia 3 | 1,160
Seizures 3 | 596
Stomach Neoplasms 3 | 300
Type 2 diabetes mellitus 3 | 272
acute myeloid leukemia 3 | 783
adrenocortical carcinoma 3 | 1,428
esophageal adenocarcinoma 3 | 737
mucosa-associated lymphoid tissue lymphoma 3 | 484
pediatric high grade glioma 3 | 1,064

Tissue

Blood and immune system 40 | 16,909
Digestive Tract 40 | 17,369
Endocrine System 40 | 18,159
Skin and soft tissues 40 | 17,230
Female tissues 39 | 17,400
Male tissues 39 | 17,142
Liver and Pancreas 38 | 16,750
Nervous System 38 | 16,725
Respiratory system 38 | 16,393
Urinary Tract 38 | 16,678
Cardiovascular System 37 | 15,192

Target Family

Non-IDG 23 | 12,091
Enzyme 12 | 4,145
Kinase 4 | 634
TF/Epigenetic 1 | 38
Transcription Factor 1 | 1,400

WikiPathways Pathway

Nucleotide-binding Oligomeriza... 41 | 41
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual oxidase 2 DUOX2 Tbio Enzyme -2.45061 251.8 126
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Angio-associated migratory cell protein AAMP Tbio Non-IDG -1.47842 30.9 123
NACHT, LRR and PYD domains-containing protein 10 NLRP10 Tbio Non-IDG -1.34432 24.4 131
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Apoptosis-associated speck-like protein containing a CARD PYCARD Tbio Non-IDG -1.86744 55.9 477
Erbin ERBIN Tbio Non-IDG -1.72357 59.1 117
Receptor-interacting serine/threonine-protein kinase 2 RIPK2 Tchem Kinase -2.03990 107.3 474
Caspase-5 CASP5 Tchem Enzyme -2.01445 96.1 427
Interleukin-1 beta IL1B Tclin Non-IDG -4.40738 24522.4 1588