Development Level

Tbio 6 | 11,445
Tchem 6 | 1,598
Tclin 6 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to o... 3 | 239
abnormal retinal vasculature m... 1 | 27
cataract 1 | 92
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
embryonic lethality prior to t... 1 | 278
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
microphthalmia 1 | 26
preweaning lethality, incomple... 1 | 499

Disease

ovarian cancer 14 | 8,520
Carcinoma 13 | 11,493
medulloblastoma, large-cell 12 | 6,241
psoriasis 12 | 6,694
atypical teratoid / rhabdoid tumor 10 | 5,112
glioblastoma 10 | 5,792
lung cancer 10 | 4,740
Cancer 8 | 2,499
primitive neuroectodermal tumor 8 | 3,035
Muscle hypotonia 7 | 571
group 3 medulloblastoma 7 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
non-small cell lung cancer 7 | 2,890
tuberculosis 7 | 2,010
Breast cancer 6 | 3,578
Dull intelligence 6 | 645
Epilepsy 6 | 792
Intellectual disability 6 | 1,016
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Poor school performance 6 | 645
Seizures 6 | 596
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
lung adenocarcinoma 6 | 2,716
malignant mesothelioma 6 | 3,232
oligodendroglioma 6 | 2,850
osteosarcoma 6 | 7,950
Acute lymphoid leukemia 5 | 25
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Mental and motor retardation 5 | 608
adrenocortical carcinoma 5 | 1,428
colon cancer 5 | 1,478
ependymoma 5 | 4,679
invasive ductal carcinoma 5 | 2,951
Adenocarcinoma of pancreas 4 | 14
Autosomal recessive predisposition 4 | 1,442
Cerebellar Ataxia 4 | 304
Deafness 4 | 198
Lesch-Nyhan syndrome 4 | 12
Malignant tumor of ovary 4 | 25
Metastatic Breast Carcinoma 4 | 21
Nystagmus 4 | 317
Purine nucleoside phosphorylase deficiency 4 | 11
Sensorineural Hearing Loss (disorder) 4 | 284
Waldenstrons macroglobulinemia 4 | 765
acute quadriplegic myopathy 4 | 1,158
adult high grade glioma 4 | 3,801
astrocytic glioma 4 | 2,597
breast carcinoma 4 | 1,638
dermatomyositis 4 | 966
diabetes mellitus 4 | 1,728
ductal carcinoma in situ 4 | 1,745
interstitial cystitis 4 | 2,312
pancreatic cancer 4 | 2,398
subependymal giant cell astrocytoma 4 | 2,287
Abnormal vision 3 | 52
Acute myeloid leukemia, disease 3 | 30
Adenocarcinoma of lung 3 | 142
Astrocytoma, Pilocytic 3 | 3,081
Atopic dermatitis 3 | 952
Colorectal Neoplasms 3 | 243
Congenital deafness 3 | 185
Deglutition Disorders 3 | 132
Depressive disorder 3 | 409
Disease Models, Animal 3 | 155
Dysarthria 3 | 192
Endometriosis 3 | 540
Gait Ataxia 3 | 51
Gout 3 | 106
Hearing Loss, Partial 3 | 185
Hepatomegaly 3 | 285
Infantile onset 3 | 238
Low Vision 3 | 174
Malignant tumor of head and/or neck 3 | 15
Meningeal Leukemia 3 | 7
Multiple myeloma 3 | 1,332
Neurogenic Muscular Atrophy 3 | 139
Neurogenic muscle atrophy, especially in the lower limbs 3 | 139
Neuropathy 3 | 261
Polycystic ovary syndrome 3 | 360
Skeletal muscle atrophy 3 | 139
Visual Impairment 3 | 174
X- linked recessive 3 | 110
cystic fibrosis 3 | 1,696
group 4 medulloblastoma 3 | 1,855
hearing impairment 3 | 199
juvenile dermatomyositis 3 | 1,187
muscle degeneration 3 | 139
nasopharyngeal carcinoma 3 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
ulcerative colitis 3 | 1,819
Absent reflex 2 | 92
Acidosis, Lactic 2 | 97
Hepatic enzyme increased 2 | 81
Liver Dysfunction 2 | 99
Liver function tests abnormal finding 2 | 81
Vomiting 2 | 116

Tissue

Blood and immune system 18 | 16,909
Cardiovascular System 18 | 15,192
Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Nervous System 18 | 16,725
Respiratory system 18 | 16,393
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678

Target Family

Enzyme 16 | 4,145
Kinase 2 | 634

WikiPathways Pathway

Nucleotide Metabolism 18 | 18
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dihydrofolate reductase DHFR Tclin Enzyme -2.99192 972.8 202
Spermidine synthase SRM Tchem Enzyme -1.65951 38.0 172
DNA polymerase subunit gamma-1 POLG Tchem Enzyme -2.63005 414.1 128
Diamine acetyltransferase 1 SAT1 Tbio Enzyme -2.60045 409.5 159
Adenylosuccinate lyase ADSL Tbio Enzyme -3.32293 2023.8 144
Ribonucleoside-diphosphate reductase subunit M2 B RRM2B Tbio Enzyme -1.91697 95.0 244
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 Tchem Enzyme -1.43089 24.9 131
Hypoxanthine-guanine phosphoribosyltransferase HPRT1 Tchem Enzyme -3.37307 2350.7 381
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.06760 110.4 225
Ornithine decarboxylase antizyme 1 OAZ1 Tbio Enzyme -1.36094 22.0 69