Development Level

Tchem 14 | 1,598
Tbio 10 | 11,445
Tclin 9 | 613

IMPC Phenotype

abnormal behavior 3 | 298
decreased mean corpuscular vol... 3 | 79
increased startle reflex 3 | 112
cataract 2 | 92
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral density 2 | 126
decreased circulating serum al... 2 | 82
decreased grip strength 2 | 116
decreased mean platelet volume 2 | 25
decreased vertical activity 2 | 208
hypoactivity 2 | 132
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating bilirubi... 2 | 16
increased circulating choleste... 2 | 66
preweaning lethality, complete... 2 | 979
abnormal bone structure 1 | 187
abnormal clavicle morphology 1 | 6
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal fibula morphology 1 | 2
abnormal gait 1 | 69
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal rib morphology 1 | 10
abnormal scapula morphology 1 | 3
abnormal seminal vesicle morph... 1 | 114
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
absent mammary gland 1 | 1
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased mean corpuscular hem... 1 | 50
decreased skeletal muscle mass 1 | 1
decreased total body fat amoun... 1 | 207
embryonic lethality prior to t... 1 | 278
hyperactivity 1 | 148
increased body weight 1 | 25
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating creatini... 1 | 38
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased circulating unsatura... 1 | 1
increased kidney weight 1 | 6
increased lactate dehydrogenas... 1 | 3
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small heart 1 | 10
small kidney 1 | 16
small ovary 1 | 1
small spleen 1 | 19
small uterus 1 | 3
thin skin 1 | 2
thin ventricular wall 1 | 24

Disease

Carcinoma 33 | 11,493
Cancer 21 | 2,499
osteosarcoma 19 | 7,950
psoriasis 19 | 6,694
Liver disease 14 | 237
ovarian cancer 14 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Chemical and Drug Induced Liver Injury 13 | 195
Cholestasis 13 | 155
diabetes mellitus 13 | 1,728
lung cancer 13 | 4,740
medulloblastoma, large-cell 13 | 6,241
Colorectal Neoplasms 11 | 243
Obesity 11 | 678
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
malignant mesothelioma 11 | 3,232
Hepatomegaly 10 | 285
glioblastoma 10 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
invasive ductal carcinoma 10 | 2,951
tuberculosis 10 | 2,010
Autosomal recessive predisposition 9 | 1,442
Kidney cancer 9 | 2,613
Schizophrenia 9 | 1,160
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
Astrocytoma, Pilocytic 7 | 3,081
Atherosclerosis 7 | 291
Lipid metabolism disorder 7 | 114
Liver carcinoma 7 | 240
ductal carcinoma in situ 7 | 1,745
lung adenocarcinoma 7 | 2,716
lung carcinoma 7 | 2,843
ulcerative colitis 7 | 1,819
Adverse reaction to drug 6 | 61
Breast Neoplasms 6 | 445
Breast cancer 6 | 3,578
Carcinoma, Hepatocellular 6 | 228
Drug-Related Side Effects and Adverse Reactions 6 | 62
Fatty liver disease 6 | 103
Leber congenital amaurosis 6 | 69
Liver Cirrhosis, Experimental 6 | 769
Mammary Neoplasms 6 | 425
active Crohn's disease 6 | 922
adrenocortical carcinoma 6 | 1,428
adult high grade glioma 6 | 3,801
atypical teratoid / rhabdoid tumor 6 | 5,112
non-small cell lung cancer 6 | 2,890
Adenocarcinoma 5 | 122
Bilirubin metabolic disorder 5 | 41
Bipolar Disorder 5 | 666
Coronary artery disease 5 | 268
Fatty Liver 5 | 70
Hypertension 5 | 396
Liver neoplasms 5 | 130
Non-alcoholic Fatty Liver Disease 5 | 42
Prostatic Neoplasms 5 | 495
Splenomegaly 5 | 190
active ulcerative colitis 5 | 764
aldosterone-producing adenoma 5 | 665
cystic fibrosis 5 | 1,696
ependymoma 5 | 4,679
esophageal adenocarcinoma 5 | 737
group 3 medulloblastoma 5 | 4,104
interstitial cystitis 5 | 2,312
pancreatic cancer 5 | 2,398
posterior fossa group A ependymoma 5 | 468
Acne vulgaris 4 | 14
Acute promyelocytic leukemia, FAB M3 4 | 11
Alkaline phosphatase serum increased 4 | 29
Cardiovascular system disease 4 | 246
Chloasma 4 | 6
Cholelithiasis 4 | 33
Diarrhea 4 | 253
Endometriosis 4 | 540
Epilepsy 4 | 792
Facial Fine Wrinkling 4 | 5
Failure to gain weight 4 | 365
Fine Wrinkling 4 | 5
Hyperkeratosis 4 | 50
Icterus 4 | 82
Infantile onset 4 | 238
Inflammatory bowel disease 4 | 151
Kaposi's Sarcoma Skin Lesions 4 | 8
Kidney Failure, Chronic 4 | 46
Kidney disease 4 | 430
Liver Cirrhosis 4 | 181
Lung Neoplasms 4 | 232
Metabolic syndrome X 4 | 52
Mottle Hyperpigmentation 4 | 5
Multiple Sclerosis 4 | 540
Pediatric failure to thrive 4 | 365
Pick disease 4 | 1,894
Rheumatoid arthritis 4 | 1,191
Severe Recalcitrant Nodular Acne 4 | 5
Solar Lentigines 4 | 6
Type 2 diabetes mellitus 4 | 272
cutaneous lupus erythematosus 4 | 1,057
fibroadenoma 4 | 559
nephrosclerosis 4 | 333
primitive neuroectodermal tumor 4 | 3,035

Tissue

Liver and Pancreas 33 | 16,750
Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Male tissues 31 | 17,142
Skin and soft tissues 31 | 17,230
Blood and immune system 30 | 16,909
Urinary Tract 29 | 16,678
Respiratory system 27 | 16,393
Nervous System 26 | 16,725
Cardiovascular System 21 | 15,192

Target Family

Nuclear Receptor 11 | 48
Transporter 10 | 473
Enzyme 6 | 4,145
Non-IDG 6 | 12,091

WikiPathways Pathway

Nuclear Receptors in Lipid Met... 33 | 33
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytochrome P450 26A1 CYP26A1 Tchem Enzyme -2.44772 290.1 197
ATP-binding cassette sub-family D member 3 ABCD3 Tbio Transporter -1.82051 64.2 166
Cytochrome P450 4A11 CYP4A11 Tbio Non-IDG -1.97180 93.7 142
Canalicular multispecific organic anion transporter 2 ABCC3 Tbio Transporter -2.46032 287.4 214
Cholesterol 7-alpha-monooxygenase CYP7A1 Tbio Enzyme -2.70498 494.6 94
ATP-binding cassette sub-family G member 1 ABCG1 Tbio Transporter -2.52701 319.9 260
Vitamin D3 receptor VDR Tclin Nuclear Receptor -3.62166 3805.7 575
ATP-binding cassette sub-family G member 5 ABCG5 Tbio Transporter -2.29380 189.0 123
Nuclear receptor subfamily 1 group I member 2 NR1I2 Tchem Nuclear Receptor -3.15331 1582.6 305
Multidrug resistance protein 1 ABCB1 Tchem Transporter -3.61827 4039.4 875