Development Level

Tbio 48 | 11,445
Tchem 23 | 1,598
Tclin 6 | 613
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal behavior 4 | 298
decreased body weight 3 | 161
decreased bone mineral density 2 | 126
decreased mean corpuscular vol... 2 | 79
decreased vertical activity 2 | 208
enlarged heart 2 | 210
enlarged kidney 2 | 14
enlarged spleen 2 | 41
increased grip strength 2 | 41
increased leukocyte cell numbe... 2 | 47
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal eating behavior 1 | 1
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal esophagus morphology 1 | 5
abnormal femur morphology 1 | 14
abnormal forced expiratory flo... 1 | 1
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal lung morphology 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal tail morphology 1 | 25
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased body temperature 1 | 2
decreased bone mineral content 1 | 151
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased grip strength 1 | 116
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
decreased thermal nociceptive ... 1 | 2
decreased tidal volume 1 | 1
edema 1 | 59
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged gallbladder 1 | 2
enlarged heart atrium 1 | 4
hemorrhage 1 | 23
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating glycerol... 1 | 9
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
pale yolk sac 1 | 25
pallor 1 | 34
polycystic kidney 1 | 15
respiratory system phenotype 1 | 2
small seminal vesicle 1 | 10
small testis 1 | 58
tremors 1 | 39
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 63 | 11,493
ovarian cancer 49 | 8,520
Cancer 45 | 2,499
osteosarcoma 43 | 7,950
psoriasis 41 | 6,694
glioblastoma 37 | 5,792
medulloblastoma, large-cell 33 | 6,241
oligodendroglioma 29 | 2,850
Breast cancer 28 | 3,578
ependymoma 28 | 4,679
lung cancer 28 | 4,740
atypical teratoid / rhabdoid tumor 25 | 5,112
Astrocytoma, Pilocytic 21 | 3,081
group 3 medulloblastoma 21 | 4,104
Breast Neoplasms 20 | 445
Mammary Neoplasms 20 | 425
astrocytoma 20 | 1,146
adult high grade glioma 19 | 3,801
astrocytic glioma 19 | 2,597
malignant mesothelioma 19 | 3,232
primitive neuroectodermal tumor 18 | 3,035
subependymal giant cell astrocytoma 18 | 2,287
Kidney cancer 17 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
tuberculosis 16 | 2,010
Alzheimer's disease 15 | 658
Rheumatoid arthritis 15 | 1,191
invasive ductal carcinoma 15 | 2,951
Schizophrenia 14 | 1,160
pituitary cancer 14 | 1,972
lung carcinoma 13 | 2,843
Carcinoma, Squamous Cell 12 | 110
ductal carcinoma in situ 12 | 1,745
interstitial cystitis 12 | 2,312
lung adenocarcinoma 12 | 2,716
non-small cell lung cancer 12 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
pediatric high grade glioma 12 | 1,064
Immune system cancer 11 | 140
Multiple myeloma 11 | 1,332
breast carcinoma 11 | 1,638
diabetes mellitus 11 | 1,728
group 4 medulloblastoma 11 | 1,855
juvenile dermatomyositis 11 | 1,187
Acquired scoliosis 10 | 281
Bipolar Disorder 10 | 666
Carcinoma, Pancreatic Ductal 10 | 20
Curvature of spine 10 | 282
Failure to gain weight 10 | 365
Lymphoid leukemia 10 | 160
Pediatric failure to thrive 10 | 365
Prostatic Neoplasms 10 | 495
ulcerative colitis 10 | 1,819
Cataract 9 | 297
Esophageal Squamous Cell Carcinoma 9 | 77
Lung Neoplasms 9 | 232
Pick disease 9 | 1,894
Squamous cell carcinoma of esophagus 9 | 77
Vascular disease 9 | 319
pancreatic cancer 9 | 2,398
primary pancreatic ductal adenocarcinoma 9 | 1,109
Adenoid Cystic Carcinoma 8 | 99
Carcinoma, Adenoid Cystic 8 | 99
Colonic Neoplasms 8 | 142
Heart disease 8 | 306
Hypoplastic mandible condyle 8 | 275
Isolated cases 8 | 72
Lens Opacities 8 | 231
Mandibular hypoplasia 8 | 275
Micrognathism 8 | 275
Mood Disorders 8 | 184
Orbital separation excessive 8 | 244
Short stature 8 | 531
Squamous cell carcinoma 8 | 129
cystic fibrosis 8 | 1,696
Alagille syndrome 7 | 15
Crohn's disease 7 | 321
Dementia 7 | 175
Depressive disorder 7 | 409
Down syndrome 7 | 499
Endometrial cancer 7 | 311
Epilepsy 7 | 792
Hyperkyphosis 7 | 111
Kyphosis deformity of spine 7 | 114
Multiple Sclerosis 7 | 540
Seizures 7 | 596
Splenomegaly 7 | 190
Stomach Neoplasms 7 | 300
Strabismus 7 | 270
Uterine Cervical Neoplasms 7 | 26
Mental Depression 6 | 333
Ventricular Septal Defects 6 | 119
acute quadriplegic myopathy 6 | 1,158
adrenocortical carcinoma 6 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
dermatomyositis 6 | 966
gastric carcinoma 6 | 807
spina bifida 6 | 1,074

Tissue

Endocrine System 79 | 18,159
Digestive Tract 78 | 17,369
Blood and immune system 77 | 16,909
Liver and Pancreas 77 | 16,750
Male tissues 77 | 17,142
Skin and soft tissues 77 | 17,230
Female tissues 76 | 17,400
Respiratory system 76 | 16,393
Urinary Tract 76 | 16,678
Cardiovascular System 75 | 15,192
Nervous System 75 | 16,725

Target Family

Non-IDG 31 | 12,091
Enzyme 21 | 4,145
Transcription Factor 14 | 1,400
Epigenetic 6 | 242
Kinase 6 | 634
Ion Channel 1 | 344

WikiPathways Pathway

Notch Signaling Pathway 79 | 79
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-1,3-N-acetylglucosaminyltransferase radical fringe RFNG Tdark Enzyme -0.37913 1.57 92
Numb-like protein NUMBL Tbio Non-IDG -2.50313 317.9 171
Hairy/enhancer-of-split related with YRPW motif protein 1 HEY1 Tbio Transcription Factor -2.28398 163.4 335
Four and a half LIM domains protein 1 FHL1 Tbio Non-IDG -2.46134 291.4 312
Probable E3 ubiquitin-protein ligase DTX2 DTX2 Tbio Enzyme -1.74890 58.1 123
Delta-like protein 3 DLL3 Tbio Non-IDG -1.68978 48.6 214
Transcription factor HES-5 HES5 Tbio Transcription Factor -2.08501 97.6 139
Gamma-secretase subunit PEN-2 PSENEN Tchem Enzyme -2.84761 677.3 204
Msx2-interacting protein SPEN Tbio Non-IDG -2.94650 839.8 43
C-terminal-binding protein 2 CTBP2 Tchem Non-IDG -2.63977 410.7 251