Development Level

Tbio 72 | 11,651
Tclin 16 | 612
Tchem 13 | 1,388

IMPC Phenotype

preweaning lethality, complete... 12 | 979
preweaning lethality, incomple... 5 | 499
embryonic lethality prior to t... 4 | 278
abnormal embryo size 3 | 220
enlarged heart 3 | 210
abnormal facial morphology 2 | 17
abnormal retina morphology 2 | 71
abnormal skin morphology 2 | 50
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased vertical activity 2 | 208
increased bone mineral density 2 | 72
increased circulating alkaline... 2 | 122
increased leukocyte cell numbe... 2 | 47
increased monocyte cell number 2 | 63
prenatal lethality prior to he... 2 | 87
abnormal behavior 1 | 298
abnormal body wall morphology 1 | 9
abnormal bone mineralization 1 | 38
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal eating behavior 1 | 1
abnormal embryo development 1 | 7
abnormal eyelid fusion 1 | 3
abnormal forced expiratory flo... 1 | 1
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal lung morphology 1 | 26
abnormal placenta size 1 | 20
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal startle reflex 1 | 15
abnormal vertebrae morphology 1 | 18
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
cleft palate 1 | 8
corneal opacity 1 | 32
cyanosis 1 | 7
decreased body temperature 1 | 2
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased thermal nociceptive ... 1 | 2
decreased tidal volume 1 | 1
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged kidney 1 | 14
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased grip strength 1 | 41
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
mammalian phenotype 1 | 17
microphthalmia 1 | 26
pallor 1 | 34
polydactyly 1 | 7
prenatal lethality 1 | 28
protruding tongue 1 | 3
small spleen 1 | 19
tremors 1 | 39

Disease

Carcinoma 69 | 11,493
Cancer 55 | 2,499
osteosarcoma 51 | 7,950
ovarian cancer 47 | 8,520
lung cancer 46 | 4,740
ependymoma 42 | 4,679
psoriasis 41 | 6,694
glioblastoma 39 | 5,792
atypical teratoid / rhabdoid tumor 35 | 5,112
medulloblastoma, large-cell 34 | 6,241
malignant mesothelioma 31 | 3,232
oligodendroglioma 31 | 2,850
Astrocytoma, Pilocytic 30 | 3,081
group 3 medulloblastoma 30 | 4,104
Breast cancer 27 | 3,578
Schizophrenia 25 | 1,160
invasive ductal carcinoma 22 | 2,951
Kidney cancer 21 | 2,613
non-small cell lung cancer 21 | 2,890
primitive neuroectodermal tumor 21 | 3,035
interstitial cystitis 20 | 2,312
Craniofacial Abnormalities 19 | 151
adult high grade glioma 19 | 3,801
Cleft Palate 18 | 271
ductal carcinoma in situ 18 | 1,745
pituitary cancer 18 | 1,972
Breast Neoplasms 17 | 445
astrocytic glioma 17 | 2,597
cystic fibrosis 17 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
subependymal giant cell astrocytoma 17 | 2,287
Mammary Neoplasms 16 | 425
Multiple myeloma 16 | 1,332
Short stature 16 | 531
breast carcinoma 16 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
lung carcinoma 16 | 2,843
Muscle hypotonia 15 | 571
Orbital separation excessive 15 | 244
Strabismus 15 | 270
group 4 medulloblastoma 15 | 1,855
lung adenocarcinoma 15 | 2,716
pancreatic cancer 15 | 2,398
pediatric high grade glioma 15 | 1,064
Autosomal recessive predisposition 13 | 1,442
Brachydactyly 13 | 156
Cleft Lip 13 | 141
Down syndrome 13 | 499
Intellectual disability 13 | 1,016
Low set ears 13 | 181
Rheumatoid arthritis 13 | 1,191
Seizures 13 | 596
Sensorineural Hearing Loss (disorder) 13 | 284
astrocytoma 13 | 1,146
tuberculosis 13 | 2,010
Cryptorchidism 12 | 296
Downward slant of palpebral fissure 12 | 158
Epilepsy 12 | 792
Hypoplastic mandible condyle 12 | 275
Hypotrophic malar bone 12 | 129
Malar flattening 12 | 129
Mandibular hypoplasia 12 | 275
Melanoma 12 | 711
Micrognathism 12 | 275
Osteoporosis 12 | 363
Stomach Neoplasms 12 | 300
acute quadriplegic myopathy 12 | 1,158
colon cancer 12 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
Bipolar Disorder 11 | 666
Concave bridge of nose 11 | 195
Deafness 11 | 198
Depressed nasal bridge 11 | 195
Depressed nasal root/bridge 11 | 195
Dull intelligence 11 | 645
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Peripheral T-cell lymphoma 11 | 25
Poor school performance 11 | 645
Primary cutaneous T-cell lymphoma 11 | 29
Small head 11 | 374
cutaneous lupus erythematosus 11 | 1,057
gastric carcinoma 11 | 807
Cognitive delay 10 | 608
Depressive disorder 10 | 409
Exophthalmos 10 | 112
Frontal bossing 10 | 157
Global developmental delay 10 | 608
Hydrocephalus 10 | 152
Mental Depression 10 | 333
Mental and motor retardation 10 | 608
Multiple Sclerosis 10 | 540
Pick disease 10 | 1,894
Prominent eyes 10 | 96
Protruding eyes 10 | 96
Short neck 10 | 140
Skin cancer 10 | 469
ulcerative colitis 10 | 1,819

Tissue

Endocrine System 95 | 18,159
Digestive Tract 93 | 17,369
Nervous System 90 | 16,725
Female tissues 89 | 17,400
Skin and soft tissues 88 | 17,230
Male tissues 85 | 17,142
Urinary Tract 85 | 16,678
Blood and immune system 83 | 16,909
Liver and Pancreas 82 | 16,750
Respiratory system 81 | 16,393
Cardiovascular System 75 | 15,192

Target Family

Transcription Factor 47 | 1,400
Non-IDG 36 | 12,091
Epigenetic 11 | 242
Kinase 4 | 634
Enzyme 2 | 4,145
GPCR 1 | 408

WikiPathways Pathway

Neural Crest Differentiation 101 | 101
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.77409 55.5 444
Neurogenic locus notch homolog protein 3 NOTCH3 Tchem Non-IDG -2.67185 458.4 499
Nuclear factor NF-kappa-B p100 subunit NFKB2 Tchem Transcription Factor -2.29577 191.3 637
Glial fibrillary acidic protein GFAP Tbio Non-IDG -3.50578 2828.7 1992
Collagen alpha-1(II) chain COL2A1 Tbio Non-IDG -2.89229 724.4 424
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.76391 516.8 355
Transcription factor 7-like 1 TCF7L1 Tbio Transcription Factor -1.20549 17.1 109
Histone deacetylase 1 HDAC1 Tclin Epigenetic -3.03775 954.3 1201
Zinc finger protein SNAI1 SNAI1 Tbio Transcription Factor -3.28636 1782.9 566
Axin-2 AXIN2 Tchem Non-IDG -2.44870 241.5 237