Development Level

Tbio 67 | 10,625
Tchem 17 | 1,890
Tclin 16 | 602
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 6 | 633
embryonic lethality prior to t... 4 | 187
preweaning lethality, incomple... 4 | 260
enlarged heart 3 | 111
abnormal coat/hair pigmentatio... 2 | 54
abnormal retina morphology 2 | 100
decreased body length 2 | 108
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
decreased lean body mass 2 | 195
increased circulating alkaline... 2 | 119
increased leukocyte cell numbe... 2 | 37
increased monocyte cell number 2 | 27
abnormal QRS complex 1 | 25
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal facial morphology 1 | 9
abnormal forced expiratory flo... 1 | 1
abnormal forebrain development 1 | 18
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 24
abnormal lung morphology 1 | 15
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retinal pigmentation 1 | 61
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
cleft palate 1 | 6
corneal opacity 1 | 25
cyanosis 1 | 6
decreased body temperature 1 | 2
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating sodium l... 1 | 18
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased mean corpuscular hem... 1 | 19
decreased prepulse inhibition 1 | 52
decreased startle reflex 1 | 48
decreased thermal nociceptive ... 1 | 4
decreased tidal volume 1 | 1
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
enlarged kidney 1 | 7
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
improved glucose tolerance 1 | 56
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating free fat... 1 | 17
increased grip strength 1 | 83
increased lymphocyte cell numb... 1 | 9
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased respiratory quotient 1 | 12
increased thermal nociceptive ... 1 | 9
limb grasping 1 | 35
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82
straub tail 1 | 26
tremors 1 | 34

Disease

Cancer 53 | 2,346
osteosarcoma 51 | 7,933
ovarian cancer 47 | 8,484
lung cancer 44 | 4,466
psoriasis 41 | 6,685
glioblastoma 38 | 5,572
medulloblastoma, large-cell 34 | 6,234
oligodendroglioma 31 | 2,849
pilocytic astrocytoma 30 | 3,086
malignant mesothelioma 29 | 3,162
atypical teratoid / rhabdoid tumor 27 | 4,369
invasive ductal carcinoma 22 | 2,950
pediatric high grade glioma 22 | 2,712
Breast cancer 21 | 3,094
non-small cell lung cancer 21 | 2,798
posterior fossa group A ependymoma 21 | 1,511
primitive neuroectodermal tumor 21 | 3,031
Carcinoma 20 | 2,147
interstitial cystitis 20 | 2,299
Craniofacial Abnormalities 19 | 147
astrocytoma 19 | 1,493
ductal carcinoma in situ 18 | 1,745
pituitary cancer 18 | 1,972
cystic fibrosis 17 | 1,665
ependymoma 17 | 2,514
group 3 medulloblastoma 17 | 2,254
group 4 medulloblastoma 17 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,988
subependymal giant cell astrocytoma 17 | 2,287
Cleft palate 16 | 125
Mammary Neoplasms 16 | 410
Multiple myeloma 16 | 1,327
atypical teratoid/rhabdoid tumor 16 | 1,095
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,289
lung carcinoma 16 | 2,844
lung adenocarcinoma 15 | 2,713
Down syndrome 14 | 548
breast carcinoma 14 | 1,614
pancreatic cancer 14 | 2,300
sonic hedgehog group medulloblastoma 14 | 1,482
Rheumatoid Arthritis 13 | 1,160
Cleft Lip 12 | 91
acute quadriplegic myopathy 12 | 1,157
adult high grade glioma 12 | 2,148
colon cancer 12 | 1,475
gastric carcinoma 12 | 832
tuberculosis 12 | 1,557
ulcerative colitis 12 | 2,087
Peripheral T-cell lymphoma 11 | 24
Primary cutaneous T-cell lymphoma 11 | 24
cutaneous lupus erythematosus 11 | 1,056
Pick disease 10 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
posterior fossa group B ependymoma 10 | 1,530
Alzheimer's disease 9 | 644
Melanoma 9 | 261
Multiple Sclerosis 9 | 498
Osteoporosis 9 | 257
Schizophrenia 9 | 501
Stomach Neoplasms 9 | 282
adrenocortical carcinoma 9 | 1,427
astrocytic glioma 9 | 2,241
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 499
Intellectual disability 8 | 573
Lung Neoplasms 8 | 171
Neoplasm Metastasis 8 | 138
Prostatic Neoplasms 8 | 471
juvenile dermatomyositis 8 | 1,189
medulloblastoma 8 | 1,524
primary pancreatic ductal adenocarcinoma 8 | 1,271
Craniosynostosis 7 | 47
Heart disease 7 | 279
Kidney disease 7 | 396
Microphthalmia 7 | 78
Osteoarthritis 7 | 96
Parkinson's disease 7 | 364
dermatomyositis 7 | 933
diabetes mellitus 7 | 1,663
Acrocephalosyndactylia 6 | 15
Cerebrovascular disease 6 | 231
Colonic Neoplasms 6 | 126
Colorectal Neoplasms 6 | 217
Duchenne muscular dystrophy 6 | 602
Endometriosis 6 | 535
Neoplasm Invasiveness 6 | 127
Neoplastic Cell Transformation 6 | 81
Neuropathy 6 | 210
Obesity 6 | 616
fibroadenoma 6 | 557
non-small cell lung carcinoma 6 | 413
spina bifida 6 | 1,064
Adenoma 5 | 165
Bladder Neoplasm 5 | 109
Crohn's disease 5 | 304
Dementia 5 | 129
Liver carcinoma 5 | 217
Neurodegenerative disease 5 | 383
Vascular disease 5 | 281
acute myeloid leukemia 5 | 780

Tissue

Digestive Tract 100 | 18,473
Endocrine System 100 | 18,512
Urinary Tract 100 | 18,444
Female tissues 99 | 18,647
Nervous System 99 | 18,561
Skin and soft tissues 99 | 18,115
Blood and immune system 98 | 17,995
Liver and Pancreas 97 | 18,136
Male tissues 97 | 17,969
Cardiovascular System 93 | 17,958
Respiratory system 93 | 17,484

Target Family

Transcription Factor 47 | 1,400
Non-IDG 36 | 11,971
Epigenetic 11 | 242
Kinase 4 | 634
Enzyme 2 | 4,146
GPCR 1 | 406

WikiPathways Pathway

Neural Crest Differentiation 101 | 101
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Myelin basic protein MBP Tbio Non-IDG -3.69577 5257.0 715
Oligodendrocyte transcription factor 3 OLIG3 Tbio Transcription Factor -0.81946 6.73 131
LIM/homeobox protein Lhx2 LHX2 Tbio Transcription Factor -1.89097 87.7 161
Delta-like protein 3 DLL3 Tbio Non-IDG -1.58510 42.7 181
Transcription factor HES-5 HES5 Tbio Transcription Factor -2.02060 88.8 104
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
Bone morphogenetic protein 4 BMP4 Tchem Non-IDG -3.16723 1539.5 438
Fibroblast growth factor receptor 1 FGFR1 Tclin Kinase -3.07424 1194.2 1600