Development Level

Tbio 19 | 11,445
Tchem 2 | 1,598
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavior 1 | 298
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating chloride... 1 | 30
decreased circulating sodium l... 1 | 22
decreased lean body mass 1 | 135
decreased red blood cell distr... 1 | 41
increased B cell number 1 | 9
increased circulating serum al... 1 | 22
increased mean corpuscular hem... 1 | 96
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134

Disease

Carcinoma 17 | 11,493
osteosarcoma 16 | 7,950
ovarian cancer 14 | 8,520
Cancer 13 | 2,499
psoriasis 9 | 6,694
glioblastoma 8 | 5,792
medulloblastoma, large-cell 8 | 6,241
ependymoma 6 | 4,679
lung cancer 6 | 4,740
malignant mesothelioma 6 | 3,232
subependymal giant cell astrocytoma 6 | 2,287
Multiple myeloma 5 | 1,332
adult high grade glioma 5 | 3,801
atypical teratoid / rhabdoid tumor 5 | 5,112
Cognitive delay 4 | 608
Global developmental delay 4 | 608
Hypothyroidism 4 | 122
Mental and motor retardation 4 | 608
Renal Cell Carcinoma 4 | 214
Schizophrenia 4 | 1,160
Weight decreased 4 | 103
astrocytic glioma 4 | 2,597
diabetes mellitus 4 | 1,728
group 4 medulloblastoma 4 | 1,855
Alzheimer Disease 3 | 83
Alzheimer's disease 3 | 658
Anemia 3 | 365
Astrocytoma, Pilocytic 3 | 3,081
Autistic Disorder 3 | 364
Breast cancer 3 | 3,578
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Epilepsy 3 | 792
Kidney cancer 3 | 2,613
Lewy Body Disease 3 | 21
Multiple, subcutaneous nodules 3 | 53
Necrosis 3 | 53
Polycystic ovary syndrome 3 | 360
Precocious Puberty 3 | 28
Seizures 3 | 596
Subcutaneous nodule 3 | 53
Weight Loss 3 | 24
dermatomyositis 3 | 966
ductal carcinoma in situ 3 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
juvenile dermatomyositis 3 | 1,187
primitive neuroectodermal tumor 3 | 3,035
spina bifida 3 | 1,074
tuberculosis 3 | 2,010
Abdominal Pain 2 | 98
Abnormality of female internal genitalia 2 | 13
Acanthosis Nigricans 2 | 27
Atelectasis 2 | 8
Brain Diseases 2 | 24
Carcinoma, Squamous Cell 2 | 110
Cardiac rhabdomyoma 2 | 5
Cerebral calcification 2 | 43
Chest Pain 2 | 38
Coughing 2 | 25
Cystic kidney 2 | 30
Diabetes Mellitus, Experimental 2 | 108
Dyspnea 2 | 76
Fibromatosis, Gingival 2 | 8
Glucose Intolerance 2 | 19
Hereditary gingival fibromatosis 2 | 8
Hyperglycemia 2 | 137
Hyperinsulinism 2 | 133
Idiopathic gingival hyperplasia 2 | 8
Impaired cognition 2 | 96
Impaired glucose tolerance 2 | 28
Infiltrate of lung 2 | 17
Insulin Resistance 2 | 72
Lethargy 2 | 77
Leukemia, Myelocytic, Acute 2 | 120
Leukemia, Myeloid, Acute 2 | 105
Low Birth Weights 2 | 69
Lymphadenopathy 2 | 62
Lymphangioleiomyomatosis 2 | 16
Lymphopenia 2 | 67
Mental impairment 2 | 95
Mesothelioma, Malignant 2 | 105
Myocardial Infarction 2 | 151
Myoclonic Epilepsies, Progressive 2 | 44
Nerve Degeneration 2 | 121
Ovarian Neoplasms 2 | 102
Pancreatitis 2 | 123
Parkinson Disease 2 | 64
Peripheral Neuropathy 2 | 134
Prominent back of the head 2 | 21
Prominent occiput 2 | 21
Pulmonary emphysema 2 | 48
Renal cyst 2 | 30
Sebaceous adenoma 2 | 26
Skin tag 2 | 14
Small for gestational age (disorder) 2 | 69
Specific learning disability 2 | 47
Squamous cell carcinoma 2 | 129
Vici syndrome 2 | 14
West Syndrome 2 | 28
hypopigmented skin patch 2 | 59

Tissue

Blood and immune system 23 | 16,909
Digestive Tract 23 | 17,369
Endocrine System 23 | 18,159
Female tissues 23 | 17,400
Liver and Pancreas 23 | 16,750
Nervous System 23 | 16,725
Respiratory system 23 | 16,393
Skin and soft tissues 23 | 17,230
Urinary Tract 23 | 16,678
Cardiovascular System 22 | 15,192
Male tissues 22 | 17,142

Target Family

Non-IDG 19 | 12,091
Kinase 3 | 634
Enzyme 1 | 4,145

WikiPathways Pathway

Nanoparticle triggered autopha... 23 | 23
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endophilin-B1 SH3GLB1 Tbio Non-IDG -1.10096 14.5 386
Cysteine protease ATG4A ATG4A Tbio Enzyme -1.07944 9.29 261
Vacuole membrane protein 1 VMP1 Tbio Non-IDG -2.49755 302.1 137
Serine/threonine-protein kinase ULK2 ULK2 Tchem Kinase -1.20211 12.1 391
Autophagy-related protein 9B ATG9B Tbio Non-IDG 0.00000 142
Autophagy-related protein 16-1 ATG16L1 Tbio Non-IDG -2.26343 183.4 600
Insulin receptor INSR Tclin Kinase -2.50045 306.8 1417
Activating molecule in BECN1-regulated autophagy protein 1 AMBRA1 Tbio Non-IDG -1.56899 41.8 254
Ubiquitin-like protein ATG12 ATG12 Tbio Non-IDG -2.17958 122.1 528
Beclin 1-associated autophagy-related key regulator ATG14 Tbio Non-IDG -1.63390 38.6 127