Development Level

Tbio 12 | 11,445
Tchem 9 | 1,598

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal testis morphology 1 | 43
decreased bone mineral content 1 | 151
decreased heart weight 1 | 27
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

Cancer 19 | 2,499
psoriasis 14 | 6,694
ovarian cancer 12 | 8,520
lung cancer 10 | 4,740
osteosarcoma 10 | 7,950
Carcinoma 9 | 11,493
glioblastoma 9 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
atypical teratoid / rhabdoid tumor 8 | 5,112
group 3 medulloblastoma 7 | 4,104
Myocardial Reperfusion Injury 6 | 37
Vascular disease 6 | 319
cutaneous lupus erythematosus 6 | 1,057
ependymoma 6 | 4,679
lung carcinoma 6 | 2,843
medulloblastoma, large-cell 6 | 6,241
Alzheimer's disease 5 | 658
Astrocytoma, Pilocytic 5 | 3,081
Diabetes Mellitus, Experimental 5 | 108
Lung Neoplasms 5 | 232
Retinal Detachment 5 | 51
Toxic encephalopathy 5 | 141
colon cancer 5 | 1,478
malignant mesothelioma 5 | 3,232
Autoimmune lymphoproliferative syndrome 4 | 11
Brain Ischemia 4 | 110
Cerebral Hemorrhage 4 | 42
Diabetes Mellitus, Non-Insulin-Dependent 4 | 145
Diabetes Mellitus, Type 2 4 | 142
Hypersensitivity reaction type II disease 4 | 253
Myocardial Infarction 4 | 151
Neurodegenerative disease 4 | 414
Parkinson's disease 4 | 392
Prostatic Neoplasms 4 | 495
Splenomegaly 4 | 190
adrenocortical carcinoma 4 | 1,428
diabetes mellitus 4 | 1,728
hepatocellular carcinoma 4 | 547
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
invasive ductal carcinoma 4 | 2,951
lung adenocarcinoma 4 | 2,716
non-small cell lung cancer 4 | 2,890
pancreatic cancer 4 | 2,398
subependymal giant cell astrocytoma 4 | 2,287
tuberculosis 4 | 2,010
ulcerative colitis 4 | 1,819
Arthritis 3 | 290
Autosomal recessive predisposition 3 | 1,442
Bipolar Disorder 3 | 666
Breast Neoplasms 3 | 445
Breast cancer 3 | 3,578
Carcinoma, Hepatocellular 3 | 228
Edema 3 | 81
Epilepsy 3 | 792
Eye disease 3 | 62
Hepatomegaly 3 | 285
Ischemic Attack, Transient 3 | 10
Liver carcinoma 3 | 240
Lymphoma, T-Cell, Cutaneous 3 | 22
Mammary Neoplasms 3 | 425
Nerve Degeneration 3 | 121
Neuropathy 3 | 261
Pick disease 3 | 1,894
Schizophrenia 3 | 1,160
Stomach Neoplasms 3 | 300
Transient Ischemic Attack 3 | 10
adult high grade glioma 3 | 3,801
aldosterone-producing adenoma 3 | 665
breast carcinoma 3 | 1,638
gastric carcinoma 3 | 807
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
oligodendroglioma 3 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pediatric high grade glioma 3 | 1,064
Alzheimer Disease 2 | 83
Amyotrophic lateral sclerosis 2 | 451
Cardiomyopathies 2 | 110
Cardiomyopathy, Dilated 2 | 83
Colonic Neoplasms 2 | 142
Diabetic Angiopathies 2 | 16
Gaucher disease type 1 2 | 180
Heart disease 2 | 306
Huntington Disease 2 | 13
Huntington's disease 2 | 76
Inflammatory bowel disease 2 | 151
Leukopenia 2 | 72
Liver Cirrhosis, Experimental 2 | 769
Liver Failure, Acute 2 | 29
Lung disease 2 | 142
Melanoma 2 | 711
Multiple Sclerosis 2 | 540
Pancreatic Neoplasm 2 | 85
Pancreatic Neoplasms 2 | 85
Pneumonia 2 | 174
Reperfusion Injury 2 | 86
Sensorineural Hearing Loss (disorder) 2 | 284
Status Epilepticus 2 | 98
Urticaria 2 | 67
hearing impairment 2 | 199

Tissue

Blood and immune system 21 | 16,909
Cardiovascular System 21 | 15,192
Digestive Tract 21 | 17,369
Endocrine System 21 | 18,159
Female tissues 21 | 17,400
Liver and Pancreas 21 | 16,750
Male tissues 21 | 17,142
Nervous System 21 | 16,725
Respiratory system 21 | 16,393
Skin and soft tissues 21 | 17,230
Urinary Tract 21 | 16,678

Target Family

Non-IDG 13 | 12,091
Enzyme 8 | 4,145

WikiPathways Pathway

Nanomaterial induced apoptosis 21 | 21
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine protease HTRA2, mitochondrial HTRA2 Tbio Enzyme -2.60032 392.5 519
Perforin-1 PRF1 Tchem Non-IDG -3.20526 1546.3 367
Cytochrome c CYCS Tbio Non-IDG -3.76637 4945.6 833
Caspase-6 CASP6 Tchem Enzyme -2.49135 293.6 874
Caspase-9 CASP9 Tchem Enzyme -3.44725 2332.0 1313
Endonuclease G, mitochondrial ENDOG Tbio Enzyme -2.22791 175.9 334
Caspase-7 CASP7 Tchem Enzyme -2.69052 418.1 800
Bcl-2 homologous antagonist/killer BAK1 Tbio Non-IDG -2.29199 175.9 554
Caspase-8 CASP8 Tchem Enzyme -3.54224 3121.4 1045
Apoptosis-inducing factor 1, mitochondrial AIFM1 Tbio Non-IDG -1.74072 50.5 637