Development Level

Tbio 86 | 11,651
Tchem 38 | 1,388
Tclin 10 | 612
Tdark 9 | 6,593

IMPC Phenotype

preweaning lethality, complete... 9 | 979
abnormal embryo size 4 | 220
embryonic lethality prior to t... 4 | 278
preweaning lethality, incomple... 4 | 499
embryonic lethality prior to o... 3 | 239
abnormal forebrain development 2 | 20
abnormal hindbrain development 2 | 16
abnormal midbrain development 2 | 20
abnormal neural tube closure 2 | 46
abnormal seminal vesicle morph... 2 | 114
decreased circulating glucose ... 2 | 126
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
decreased prepulse inhibition 2 | 82
embryonic growth retardation 2 | 106
impaired glucose tolerance 2 | 75
increased body length 2 | 32
increased grip strength 2 | 41
male infertility 2 | 123
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal coat-hair pigmentatio... 1 | 64
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal hair growth 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal vitreous body morphol... 1 | 10
absent seminal vesicle 1 | 4
absent testes 1 | 6
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating creatine... 1 | 4
decreased exploration in new e... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
decreased urine creatinine lev... 1 | 3
decreased vertical activity 1 | 208
enlarged epididymis 1 | 31
female infertility 1 | 60
increased blood urea nitrogen ... 1 | 48
increased circulating bilirubi... 1 | 16
increased circulating creatine... 1 | 5
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased kidney weight 1 | 6
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
limb grasping 1 | 41
prenatal lethality prior to he... 1 | 87
prolonged QRS complex duration 1 | 8
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
small heart 1 | 10
small uterus 1 | 3
thrombocytosis 1 | 27

Disease

Carcinoma 97 | 11,493
psoriasis 66 | 6,694
ovarian cancer 65 | 8,520
lung cancer 63 | 4,740
osteosarcoma 62 | 7,950
Cancer 60 | 2,499
medulloblastoma, large-cell 54 | 6,241
glioblastoma 51 | 5,792
lung carcinoma 43 | 2,843
non-small cell lung cancer 42 | 2,890
malignant mesothelioma 41 | 3,232
atypical teratoid / rhabdoid tumor 39 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 39 | 3,291
ependymoma 35 | 4,679
Breast cancer 34 | 3,578
pancreatic cancer 34 | 2,398
lung adenocarcinoma 33 | 2,716
group 3 medulloblastoma 31 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 31 | 2,955
diabetes mellitus 30 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,989
interstitial cystitis 29 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 29 | 1,962
tuberculosis 29 | 2,010
adult high grade glioma 28 | 3,801
Schizophrenia 26 | 1,160
invasive ductal carcinoma 25 | 2,951
Astrocytoma, Pilocytic 23 | 3,081
cystic fibrosis 22 | 1,696
oligodendroglioma 22 | 2,850
Prostatic Neoplasms 21 | 495
astrocytic glioma 20 | 2,597
primitive neuroectodermal tumor 20 | 3,035
Obesity 19 | 678
colon cancer 19 | 1,478
subependymal giant cell astrocytoma 19 | 2,287
ulcerative colitis 19 | 1,819
acute quadriplegic myopathy 18 | 1,158
Rheumatoid arthritis 17 | 1,191
active Crohn's disease 17 | 922
adrenocortical carcinoma 17 | 1,428
pituitary cancer 17 | 1,972
Carcinoma, Hepatocellular 16 | 228
Contact Dermatitis 16 | 81
Dermatitis, Contact 16 | 71
esophageal adenocarcinoma 16 | 737
group 4 medulloblastoma 16 | 1,855
Autosomal recessive predisposition 15 | 1,442
Hypertension 15 | 396
Kidney disease 15 | 430
Liver Cirrhosis, Experimental 15 | 769
Liver carcinoma 15 | 240
Vascular disease 15 | 319
Bipolar Disorder 14 | 666
Lung Neoplasms 14 | 232
Multiple myeloma 14 | 1,332
active ulcerative colitis 14 | 764
nasopharyngeal carcinoma 14 | 1,058
Chemical and Drug Induced Liver Injury 13 | 195
Hyperglycemia 13 | 137
ductal carcinoma in situ 13 | 1,745
Bilirubin metabolic disorder 12 | 41
Breast Neoplasms 12 | 445
Depressive disorder 12 | 409
Epilepsy 12 | 792
Kidney cancer 12 | 2,613
Mammary Neoplasms 12 | 425
Neoplasm Metastasis 12 | 168
breast carcinoma 12 | 1,638
non-small cell lung carcinoma 12 | 317
Alzheimer's disease 11 | 658
Cholestasis 11 | 155
Liver disease 11 | 237
Neurodegenerative Disorders 11 | 79
Pick disease 11 | 1,894
astrocytoma 11 | 1,146
mucosa-associated lymphoid tissue lymphoma 11 | 484
nephrosclerosis 11 | 333
non primary Sjogren syndrome sicca 11 | 891
primary pancreatic ductal adenocarcinoma 11 | 1,109
Acute kidney injury 10 | 70
Alcoholic Intoxication, Chronic 10 | 289
Colorectal Neoplasms 10 | 243
Down syndrome 10 | 499
Hypertensive disease 10 | 292
Hypoglycemia 10 | 152
Myocardial Ischemia 10 | 169
head and neck cancer and chronic obstructive pulmonary disease 10 | 239
Neurodegenerative Diseases 9 | 38
Neurodegenerative disease 9 | 414
Parkinson's disease 9 | 392
Waldenstrons macroglobulinemia 9 | 765
aldosterone-producing adenoma 9 | 665
pediatric high grade glioma 9 | 1,064
spina bifida 9 | 1,074
Attention deficit hyperactivity disorder 8 | 278
Endometriosis 8 | 540
acute myeloid leukemia 8 | 783
gastric cancer 8 | 459
hepatocellular carcinoma 8 | 547

Tissue

Digestive Tract 136 | 17,369
Endocrine System 136 | 18,159
Male tissues 133 | 17,142
Urinary Tract 133 | 16,678
Skin and soft tissues 132 | 17,230
Female tissues 131 | 17,400
Liver and Pancreas 129 | 16,750
Respiratory system 128 | 16,393
Nervous System 127 | 16,725
Blood and immune system 123 | 16,909
Cardiovascular System 103 | 15,192

Target Family

Transporter 63 | 473
Enzyme 49 | 4,145
Non-IDG 22 | 12,091
Transcription Factor 4 | 1,400
Kinase 3 | 634
Nuclear Receptor 2 | 48

WikiPathways Pathway

NRF2 pathway 143 | 143
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sodium-dependent serotonin transporter SLC6A4 Tclin Transporter -3.63283 4453.8 245
Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 Tchem Enzyme -2.12624 141.3 310
Zinc transporter ZIP1 SLC39A1 Tbio Transporter -1.89903 75.9 61
Sodium/myo-inositol cotransporter 2 SLC5A11 Tchem Transporter -1.76250 46.1 82
Proton myo-inositol cotransporter SLC2A13 Tbio Transporter -1.10021 10.8 71
Sequestosome-1 SQSTM1 Tbio Non-IDG -2.78728 635.1 766
Microsomal glutathione S-transferase 2 MGST2 Tbio Enzyme -1.15686 13.6 120
Zinc transporter ZIP12 SLC39A12 Tbio Transporter -0.88750 7.66 42
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222
Protransforming growth factor alpha TGFA Tbio Non-IDG -2.15761 135.3 697