Development Level

Tbio 11 | 11,445
Tchem 3 | 1,598
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal eating behavior 1 | 1
abnormal forced expiratory flo... 1 | 1
abnormal heart morphology 1 | 162
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
decreased body temperature 1 | 2
decreased body weight 1 | 161
decreased tidal volume 1 | 1
decreased vertical activity 1 | 208
enlarged heart 1 | 210
increased blood urea nitrogen ... 1 | 48
increased circulating iron lev... 1 | 30
increased grip strength 1 | 41
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased monocyte cell number 1 | 63
small testis 1 | 58

Disease

Carcinoma 13 | 11,493
psoriasis 12 | 6,694
Breast cancer 11 | 3,578
glioblastoma 11 | 5,792
Astrocytoma, Pilocytic 10 | 3,081
Cancer 10 | 2,499
ovarian cancer 10 | 8,520
Schizophrenia 9 | 1,160
medulloblastoma, large-cell 9 | 6,241
oligodendroglioma 9 | 2,850
ependymoma 8 | 4,679
lung carcinoma 8 | 2,843
osteosarcoma 8 | 7,950
adult high grade glioma 7 | 3,801
cystic fibrosis 7 | 1,696
group 3 medulloblastoma 7 | 4,104
malignant mesothelioma 7 | 3,232
non-small cell lung cancer 7 | 2,890
pancreatic cancer 7 | 2,398
primary pancreatic ductal adenocarcinoma 7 | 1,109
Breast Neoplasms 6 | 445
Mammary Neoplasms 6 | 425
adrenocortical carcinoma 6 | 1,428
astrocytic glioma 6 | 2,597
colon cancer 6 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
lung adenocarcinoma 6 | 2,716
lung cancer 6 | 4,740
pituitary cancer 6 | 1,972
ulcerative colitis 6 | 1,819
Brachydactyly 5 | 156
diabetes mellitus 5 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
invasive ductal carcinoma 5 | 2,951
Autosomal recessive predisposition 4 | 1,442
Carcinoma, Pancreatic Ductal 4 | 20
Cataract 4 | 297
Craniofacial Abnormalities 4 | 151
Duchenne muscular dystrophy 4 | 601
Exophthalmos 4 | 112
Failure to gain weight 4 | 365
Fetal Growth Retardation 4 | 189
Hypertension 4 | 396
Infant, Small for Gestational Age 4 | 176
Intrauterine retardation 4 | 176
Kidney disease 4 | 430
Obesity 4 | 678
Pediatric failure to thrive 4 | 365
Prominent eyes 4 | 96
Prominent globes 4 | 96
Protruding eyes 4 | 96
Short distal phalanges 4 | 50
Strabismus 4 | 270
Tetralogy of Fallot 4 | 63
astrocytoma 4 | 1,146
atypical teratoid / rhabdoid tumor 4 | 5,112
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
juvenile dermatomyositis 4 | 1,187
primitive neuroectodermal tumor 4 | 3,035
subependymal giant cell astrocytoma 4 | 2,287
Alzheimer's disease 3 | 658
Anemia 3 | 365
Atherosclerosis 3 | 291
Atopic dermatitis 3 | 952
Bilateral fifth finger clinodactyly 3 | 110
Broad forehead 3 | 59
Cerebrovascular disease 3 | 238
Concave bridge of nose 3 | 195
Curvature of little finger 3 | 110
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Epilepsy 3 | 792
Frontal bossing 3 | 157
Heart disease 3 | 306
Kidney cancer 3 | 2,613
Lens Opacities 3 | 231
Liver Cirrhosis 3 | 181
Liver Cirrhosis, Experimental 3 | 769
Long narrow head 3 | 75
Narrow cranium shape 3 | 75
Narrow head shape 3 | 75
Narrow skull shape 3 | 75
Osteochondrodysplasias 3 | 72
Respiratory Insufficiency 3 | 132
Seizures 3 | 596
Short stature 3 | 531
Turridolichocephaly 3 | 75
Underdeveloped brows 3 | 38
Underdeveloped supraorbital ridges 3 | 38
Ventricular Septal Defects 3 | 119
acute quadriplegic myopathy 3 | 1,158
chronic rhinosinusitis 3 | 512
dermatomyositis 3 | 966
gastric carcinoma 3 | 807
limb girdle muscular dystrophy 2A 3 | 213
mucosa-associated lymphoid tissue lymphoma 3 | 484
pediatric high grade glioma 3 | 1,064
sonic hedgehog group medulloblastoma 3 | 467

Tissue

Blood and immune system 17 | 16,909
Digestive Tract 17 | 17,369
Endocrine System 17 | 18,159
Nervous System 17 | 16,725
Cardiovascular System 16 | 15,192
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Respiratory system 16 | 16,393
Skin and soft tissues 16 | 17,230
Urinary Tract 16 | 16,678

Target Family

Non-IDG 11 | 12,091
Enzyme 3 | 4,145
GPCR 1 | 408
Kinase 1 | 634
Transcription Factor 1 | 1,400

WikiPathways Pathway

NOTCH1 regulation of human end... 17 | 17
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Delta-like protein 3 DLL3 Tbio Non-IDG -1.68978 48.6 214
Gap junction alpha-5 protein GJA5 Tbio Non-IDG -2.59423 377.5 194
Fibroblast growth factor receptor 3 FGFR3 Tclin Kinase -3.00731 1050.1 479
Tissue-type plasminogen activator PLAT Tclin Enzyme -3.71677 5819.3 555
Transcription factor SOX-6 SOX6 Tbio Transcription Factor -2.07304 118.4 172
Matrix Gla protein MGP Tbio Non-IDG -2.97429 878.1 151
Diamine acetyltransferase 1 SAT1 Tbio Enzyme -2.60045 409.5 159
Protein jagged-1 JAG1 Tbio Non-IDG -3.09216 1190.8 473
Calumenin CALU Tbio Non-IDG -1.80924 66.0 177
Protein jagged-2 JAG2 Tbio Non-IDG -2.56606 327.5 353