Development Level

Tchem 23 | 1,598
Tclin 15 | 613
Tbio 9 | 11,445

Collection

Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

decreased body weight 3 | 161
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating sodium l... 2 | 22
decreased total body fat amoun... 2 | 207
enlarged heart 2 | 210
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
absent testes 1 | 6
decreased bone mineral content 1 | 151
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged spleen 1 | 41
enlarged uterus 1 | 11
hypoactivity 1 | 132
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating free fat... 1 | 20
increased circulating fructosa... 1 | 13
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
tremors 1 | 39

Disease

Carcinoma 34 | 11,493
glioblastoma 26 | 5,792
medulloblastoma, large-cell 25 | 6,241
ependymoma 24 | 4,679
adult high grade glioma 22 | 3,801
atypical teratoid / rhabdoid tumor 21 | 5,112
osteosarcoma 20 | 7,950
psoriasis 20 | 6,694
Astrocytoma, Pilocytic 19 | 3,081
ovarian cancer 19 | 8,520
primitive neuroectodermal tumor 17 | 3,035
Schizophrenia 16 | 1,160
group 3 medulloblastoma 16 | 4,104
Cancer 15 | 2,499
oligodendroglioma 15 | 2,850
Bipolar Disorder 14 | 666
Pick disease 14 | 1,894
Toxic encephalopathy 14 | 141
lung cancer 14 | 4,740
tuberculosis 14 | 2,010
Kidney cancer 13 | 2,613
astrocytic glioma 13 | 2,597
diabetes mellitus 13 | 1,728
ulcerative colitis 13 | 1,819
Alzheimer's disease 12 | 658
Brain Ischemia 12 | 110
Cerebrovascular disease 12 | 238
Depressive disorder 11 | 409
Hypertension 11 | 396
Hypertensive disease 11 | 292
Parkinson's disease 11 | 392
lung carcinoma 11 | 2,843
Breast Neoplasms 10 | 445
Mammary Neoplasms 10 | 425
Mental Depression 10 | 333
malignant mesothelioma 10 | 3,232
Breast cancer 9 | 3,578
Liver Cirrhosis, Experimental 9 | 769
colon cancer 9 | 1,478
lung adenocarcinoma 9 | 2,716
Colonic Neoplasms 8 | 142
Heart disease 8 | 306
Heart failure 8 | 162
Kidney disease 8 | 430
Major Depressive Disorder 8 | 301
Melanoma 8 | 711
Myocardial Infarction 8 | 151
Rheumatoid arthritis 8 | 1,191
group 4 medulloblastoma 8 | 1,855
interstitial cystitis 8 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
pancreatic cancer 8 | 2,398
Alcoholic Intoxication, Chronic 7 | 289
Asthma 7 | 385
Autosomal recessive predisposition 7 | 1,442
Brain disease 7 | 96
Coronary artery disease 7 | 268
Diabetes Mellitus, Experimental 7 | 108
Hyperalgesia 7 | 83
Lung disease 7 | 142
Obesity 7 | 678
Pulmonary hypertension 7 | 85
Unipolar Depression 7 | 250
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
non-small cell lung cancer 7 | 2,890
subependymal giant cell astrocytoma 7 | 2,287
Adenocarcinoma 6 | 122
Atherosclerosis 6 | 291
Autistic Disorder 6 | 364
Cardiomegaly 6 | 116
Chronic heart failure 6 | 46
Decompensated cardiac failure 6 | 9
Diabetes Mellitus, Non-Insulin-Dependent 6 | 145
Diabetes Mellitus, Type 2 6 | 142
Epilepsy 6 | 792
Hypotension 6 | 82
Intellectual disability 6 | 1,016
Multiple Sclerosis 6 | 540
Myocardial Ischemia 6 | 169
Reperfusion Injury 6 | 86
acute myeloid leukemia 6 | 783
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
non primary Sjogren syndrome sicca 6 | 891
Atrial Fibrillation 5 | 124
Colitis 5 | 54
Dementia 5 | 175
Highly variable severity 5 | 157
Inflammatory bowel disease 5 | 151
Lung Neoplasms 5 | 232
Mood Disorders 5 | 184
Prostatic Neoplasms 5 | 495
Seizures 5 | 596
Variable expressivity 5 | 157
acute quadriplegic myopathy 5 | 1,158
astrocytoma 5 | 1,146
cystic fibrosis 5 | 1,696
pancreatic carcinoma 5 | 562
periodontitis 5 | 293
pituitary cancer 5 | 1,972
primary Sjogren syndrome 5 | 735

Tissue

Endocrine System 45 | 18,159
Digestive Tract 44 | 17,369
Liver and Pancreas 44 | 16,750
Blood and immune system 43 | 16,909
Female tissues 43 | 17,400
Male tissues 43 | 17,142
Nervous System 43 | 16,725
Respiratory system 43 | 16,393
Skin and soft tissues 43 | 17,230
Urinary Tract 43 | 16,678
Cardiovascular System 36 | 15,192

Target Family

Non-IDG 14 | 12,091
Enzyme 13 | 4,145
Ion Channel 11 | 344
Kinase 6 | 634
Transcription Factor 3 | 1,400

WikiPathways Pathway

NO/cGMP/PKG mediated Neuroprot... 47 | 47
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Putative peripheral benzodiazepine receptor-related protein TSPO Tchem Non-IDG -3.08695 2284.2 212
Calcium/calmodulin-dependent protein kinase type II subunit gamma CAMK2G Tchem Kinase -0.94556 7.03 308
Calcium/calmodulin-dependent protein kinase type II subunit beta CAMK2B Tchem Kinase -1.14550 13.6 344
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.82317 50.9 620
Nitric oxide synthase, inducible NOS2 Tchem Enzyme -3.35134 2277.5 752
Cytochrome c CYCS Tbio Non-IDG -3.76637 4945.6 833
Caspase-9 CASP9 Tchem Enzyme -3.44725 2332.0 1313
Guanylate cyclase soluble subunit beta-2 GUCY1B2 Tclin Enzyme 0.00000 0
cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A Tclin Enzyme -1.83472 64.6 190
Bcl2-associated agonist of cell death BAD Tchem Non-IDG -2.08893 103.4 2565