Development Level

Tchem 7 | 1,598
Tbio 2 | 11,445

IMPC Phenotype

abnormal lens morphology 1 | 81
decreased monocyte cell number 1 | 8
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
increased lymphocyte cell numb... 1 | 32
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

Cancer 7 | 2,499
Carcinoma 6 | 11,493
osteosarcoma 6 | 7,950
glioblastoma 5 | 5,792
ovarian cancer 5 | 8,520
atypical teratoid / rhabdoid tumor 4 | 5,112
ependymoma 4 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
Autosomal recessive predisposition 3 | 1,442
Cholestasis, Extrahepatic 3 | 25
Immunologic Deficiency Syndromes 3 | 113
Kidney cancer 3 | 2,613
adult high grade glioma 3 | 3,801
diabetes mellitus 3 | 1,728
group 4 medulloblastoma 3 | 1,855
lung cancer 3 | 4,740
psoriasis 3 | 6,694
Acquired scoliosis 2 | 281
Agammaglobulinemia 2 | 34
Arthritis 2 | 290
Asthma 2 | 385
Astrocytoma, Pilocytic 2 | 3,081
Attention deficit hyperactivity disorder 2 | 278
Breast Neoplasms 2 | 445
Breast cancer 2 | 3,578
Cell Transformation, Neoplastic 2 | 97
Curvature of spine 2 | 282
Dental abnormalities 2 | 60
Flexion contracture of proximal interphalangeal joint 2 | 75
Hyperglycemia 2 | 137
Hypertension 2 | 396
IgG Deficiency 2 | 22
Immunoglobulin A deficiency (disorder) 2 | 19
Impaired memory B-cell generation 2 | 3
Increased IgM levels 2 | 16
Increased susceptibility to bacterial infections 2 | 42
Inflammatory bowel disease 2 | 151
Kidney disease 2 | 430
Mammary Neoplasms 2 | 425
Multiple myeloma 2 | 1,332
Neoplastic Cell Transformation 2 | 89
Obesity 2 | 678
Prone to bacterial infection 2 | 42
Recurrent bacterial infection 2 | 42
Reperfusion Injury 2 | 86
Rheumatoid arthritis 2 | 1,191
Schizophrenia 2 | 1,160
Short stature 2 | 531
Small head 2 | 374
Tooth Abnormalities 2 | 69
active Crohn's disease 2 | 922
astrocytoma 2 | 1,146
colon cancer 2 | 1,478
cutaneous lupus erythematosus 2 | 1,057
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
juvenile dermatomyositis 2 | 1,187
malignant mesothelioma 2 | 3,232
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
primary pancreatic ductal adenocarcinoma 2 | 1,109
primitive neuroectodermal tumor 2 | 3,035
tuberculosis 2 | 2,010
Agenesis of teeth 1 | 21
Anhidrotic ectodermal dysplasia-immunodeficiency-osteopetrosis-lymphedema syndrome 1 | 1
Atypical Mycobacteriosis, Familial, X-Linked 1 1 | 1
Barrett Esophagus 1 | 16
Blastic phase chronic myeloid leukemia 1 | 58
Brain Neoplasms 1 | 33
Brain cancer 1 | 30
Chromosome 1q21.1 deletion syndrome 1 | 12
Chronic Myelocytic Leukemia Accelerated Phase 1 | 59
Congenital sensorineural hearing loss 1 | 12
Diabetic Nephropathy 1 | 34
Hamman-Rich syndrome 1 | 34
Hearing abnormality 1 | 12
Hypohidrotic ectodermal dysplasia with immunodeficiency 1 | 2
Hypoplasia of muscle 1 | 5
IgE deficiency 1 | 2
Impaired Ig class-switch recombination (CSR) 1 | 3
Incontinentia Pigmenti 1 | 1
Incontinentia pigmenti syndrome 1 | 1
Invasive pneumococcal disease, recurrent isolated, 2 1 | 1
Kidney Failure, Chronic 1 | 46
Lymph nodes lack germinal center 1 | 3
Malignant neoplasm of prostate 1 | 11
Mitral regurgitation, mild 1 | 32
Nance-Horan syndrome 1 | 25
Neoplasms, Experimental 1 | 40
Peg shaped front tooth 1 | 6
Periodontal disease 1 | 40
Pointed front tooth 1 | 6
Popliteal pterygium syndrome 1 | 6
Precancerous Conditions 1 | 80
Reduced number of teeth 1 | 21
Short thumb terminal phalanx 1 | 5
Skin Abnormalities 1 | 37
Skin Neoplasms 1 | 69
Tetanus 1 | 68
Trigeminal Neuralgia 1 | 24

Tissue

Blood and immune system 9 | 16,909
Cardiovascular System 9 | 15,192
Digestive Tract 9 | 17,369
Endocrine System 9 | 18,159
Female tissues 9 | 17,400
Liver and Pancreas 9 | 16,750
Male tissues 9 | 17,142
Nervous System 9 | 16,725
Respiratory system 9 | 16,393
Skin and soft tissues 9 | 17,230
Urinary Tract 9 | 16,678

Target Family

Kinase 6 | 634
Non-IDG 2 | 12,091
Transcription Factor 1 | 1,400

WikiPathways Pathway

NLR Proteins 9 | 9
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tumor necrosis factor receptor superfamily member 5 CD40 Tchem Non-IDG -3.50040 3120.3 1879
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Erbin ERBIN Tbio Non-IDG -1.72357 59.1 117
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.46817 32.4 765
Inhibitor of nuclear factor kappa-B kinase subunit alpha CHUK Tchem Kinase -2.36360 203.6 1101
Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB Tchem Kinase -2.93125 790.1 1824
Transcription factor p65 RELA Tchem Transcription Factor -3.00328 988.5 2215
Mitogen-activated protein kinase 8 MAPK8 Tchem Kinase -3.81256 5770.8 1150
Ephrin type-B receptor 2 EPHB2 Tchem Kinase -2.68735 498.5 483