Development Level

Tbio 5 | 11,445
Tchem 3 | 1,598

IMPC Phenotype

abnormal seminal vesicle morph... 2 | 114
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal sensory capabilities-... 1 | 8
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased lymphocyte cell numb... 1 | 83
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
female infertility 1 | 60
hydrometra 1 | 53
increased circulating fructosa... 1 | 13
increased circulating potassiu... 1 | 29
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
microphthalmia 1 | 26
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74

Disease

Carcinoma 5 | 11,493
Pellagra 4 | 26
ductal carcinoma in situ 4 | 1,745
invasive ductal carcinoma 4 | 2,951
ovarian cancer 4 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Breast cancer 3 | 3,578
Major Depressive Disorder 3 | 301
Unipolar Depression 3 | 250
breast carcinoma 3 | 1,638
cutaneous lupus erythematosus 3 | 1,057
glioblastoma 3 | 5,792
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
osteosarcoma 3 | 7,950
pancreatic cancer 3 | 2,398
primary Sjogren syndrome 3 | 735
psoriasis 3 | 6,694
Astrocytoma, Pilocytic 2 | 3,081
Liver Cirrhosis, Experimental 2 | 769
Schizophrenia 2 | 1,160
adult high grade glioma 2 | 3,801
cystic fibrosis 2 | 1,696
head and neck cancer and chronic obstructive pulmonary disease 2 | 239
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
lung cancer 2 | 4,740
lung carcinoma 2 | 2,843
malignant mesothelioma 2 | 3,232
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 2,010
ulcerative colitis 2 | 1,819
Abnormal urinary amino-acid findings 1 | 38
Abnormality of the musculature 1 | 16
Abnormality of the respiratory system 1 | 4
Age related macular degeneration 1 | 72
Aminoaciduria 1 | 38
Amyotrophic lateral sclerosis 1 | 451
Atopic dermatitis 1 | 952
Autistic Disorder 1 | 364
Bipolar Disorder 1 | 666
Blindness 1 | 88
Comatose 1 | 56
Congenital deafness 1 | 185
Deafness 1 | 198
Depressed mood 1 | 17
Depression, Bipolar 1 | 12
Dermatitis, Allergic Contact 1 | 67
Elevated heart rate 1 | 25
Fundus dystrophy 1 | 83
Gilles de la Tourette syndrome 1 | 47
Hearing Loss, Partial 1 | 185
Hereditary macular coloboma 1 | 5
Huntington's disease 1 | 76
Hypotension 1 | 82
Inflammation 1 | 120
Iridocyclitis 1 | 19
Leber congenital amaurosis 1 | 69
Macular degeneration 1 | 65
Metabolic acidosis 1 | 90
Multiple Sclerosis 1 | 540
Muscle Hypertonia 1 | 88
Narcolepsy 1 | 72
Neurobehavioral Manifestations 1 | 9
Neurodegenerative Diseases 1 | 38
Neurodegenerative Disorders 1 | 79
Nonorganic psychosis 1 | 84
Photosensitivity disease 1 | 1
Pick disease 1 | 1,894
Porphyria 1 | 10
Psychotic Disorders 1 | 151
Rectal prolapse 1 | 19
Renal tubular disorder 1 | 12
Retinal Degeneration 1 | 106
Rickets 1 | 49
SCHIZOPHRENIA 1 (disorder) 1 | 1
Starvation 1 | 1
Tachycardia 1 | 43
Waldenstrons macroglobulinemia 1 | 765
active Crohn's disease 1 | 922
active ulcerative colitis 1 | 764
adrenocortical carcinoma 1 | 1,428
astrocytic glioma 1 | 2,597
chronic rhinosinusitis 1 | 512
gastric carcinoma 1 | 807
hearing impairment 1 | 199
lung adenocarcinoma 1 | 2,716
medulloblastoma 1 | 720
mucosa-associated lymphoid tissue lymphoma 1 | 484
nephrosclerosis 1 | 333
nutritional deficiency disease 1 | 9
pediatric high grade glioma 1 | 1,064
periodontitis 1 | 293
pituitary cancer 1 | 1,972
posterior fossa group A ependymoma 1 | 468
primary pancreatic ductal adenocarcinoma 1 | 1,109
spina bifida 1 | 1,074
urothelial carcinoma 1 | 318

Tissue

Blood and immune system 8 | 16,909
Digestive Tract 8 | 17,369
Endocrine System 8 | 18,159
Female tissues 8 | 17,400
Liver and Pancreas 8 | 16,750
Male tissues 8 | 17,142
Nervous System 8 | 16,725
Respiratory system 8 | 16,393
Skin and soft tissues 8 | 17,230
Urinary Tract 8 | 16,678
Cardiovascular System 7 | 15,192

Target Family

Enzyme 8 | 4,145

WikiPathways Pathway

NAD Biosynthesis II (from tryp... 8 | 8
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glutamine-dependent NAD(+) synthetase NADSYN1 Tbio Enzyme -1.21917 15.2 60
Kynureninase KYNU Tchem Enzyme -1.61116 39.2 173
Kynurenine formamidase AFMID Tbio Enzyme -1.65562 44.8 67
3-hydroxyanthranilate 3,4-dioxygenase HAAO Tbio Enzyme -1.76359 56.1 114
Kynurenine 3-monooxygenase KMO Tchem Enzyme -2.15501 134.1 127
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 NMNAT1 Tbio Enzyme -1.90480 77.3 145
Tryptophan 2,3-dioxygenase TDO2 Tchem Enzyme -2.89113 773.6 193
Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT Tbio Enzyme -2.02559 104.4 189