Development Level

Tbio 7 | 10,625
Tchem 6 | 1,890
Tclin 2 | 602
Tdark 1 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

abnormal gait 2 | 51
decreased rib number 2 | 59
increased circulating choleste... 2 | 53
preweaning lethality, incomple... 2 | 260
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal brain morphology 1 | 6
abnormal embryo size 1 | 112
abnormal heart morphology 1 | 51
abnormal iris morphology 1 | 12
abnormal maxilla morphology 1 | 16
abnormal neural tube morpholog... 1 | 8
abnormal placement of pupils 1 | 4
abnormal retinal inner nuclear... 1 | 5
abnormal skin morphology 1 | 23
abnormal snout morphology 1 | 18
abnormal tooth morphology 1 | 24
decreased grip strength 1 | 123
decreased total retina thickne... 1 | 20
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
hydroencephaly 1 | 6
hyperactivity 1 | 108
increased bone mineral density 1 | 52
increased circulating fructosa... 1 | 11
increased circulating total pr... 1 | 20
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
irregularly shaped pupil 1 | 7
narrow eye opening 1 | 15
pale yolk sac 1 | 12
preweaning lethality, complete... 1 | 633

Disease

Cancer 11 | 2,346
diabetes mellitus 10 | 1,663
osteosarcoma 10 | 7,933
Obesity 9 | 616
ovarian cancer 9 | 8,492
medulloblastoma, large-cell 8 | 6,234
Metabolic syndrome X 6 | 155
glioblastoma 6 | 5,572
psoriasis 6 | 6,685
atypical teratoid / rhabdoid tumor 5 | 4,369
lung cancer 5 | 4,473
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
Arthritis 3 | 248
Atherosclerosis 3 | 275
Multiple myeloma 3 | 1,328
Vascular disease 3 | 281
adrenocortical carcinoma 3 | 1,427
astrocytic glioma 3 | 2,241
cutaneous lupus erythematosus 3 | 1,056
group 4 medulloblastoma 3 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,988
invasive ductal carcinoma 3 | 2,950
lung carcinoma 3 | 2,844
malignant mesothelioma 3 | 3,163
pilocytic astrocytoma 3 | 3,086
primitive neuroectodermal tumor 3 | 3,031
tuberculosis 3 | 1,563
Anemia 2 | 252
Breast cancer 2 | 3,099
Ceroid lipofuscinosis, neuronal 1, infantile 2 | 10
Colitis 2 | 46
Fatty Liver 2 | 48
Fatty liver disease 2 | 86
Huntington's disease 2 | 72
Mammary Neoplasms 2 | 410
Neurodegenerative disease 2 | 383
Parkinson's disease 2 | 364
Pick disease 2 | 1,893
Pneumonia 2 | 133
Polycystic Ovary Syndrome 2 | 335
Prostatic Neoplasms 2 | 471
Waldenstrons macroglobulinemia 2 | 765
adult high grade glioma 2 | 2,148
astrocytoma 2 | 1,493
axial spondyloarthropathy 2 | 28
chronic lymphocytic leukemia 2 | 244
cystic fibrosis 2 | 1,670
ductal carcinoma in situ 2 | 1,745
ependymoma 2 | 2,514
gastric carcinoma 2 | 832
group 3 medulloblastoma 2 | 2,254
interstitial cystitis 2 | 2,299
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,289
lung adenocarcinoma 2 | 2,714
non-small cell lung cancer 2 | 2,798
pancreatic cancer 2 | 2,300
pediatric high grade glioma 2 | 2,712
primary Sjogren syndrome 2 | 789
subependymal giant cell astrocytoma 2 | 2,287
ulcerative colitis 2 | 2,087
Acute kidney injury 1 | 65
Alopecia 1 | 55
Autoimmune Diseases 1 | 33
Barrett's esophagus 1 | 185
Blindness 1 | 84
Brain infarction 1 | 17
COPD 1 | 116
Cardiomyopathies 1 | 90
Cerebrovascular disease 1 | 231
Colorectal Neoplasms 1 | 217
Dermatitis 1 | 141
Dermatitis, Allergic Contact 1 | 66
Diabetes Mellitus, Experimental 1 | 106
Fibrosis 1 | 40
Fundus dystrophy 1 | 77
HIV Infections 1 | 100
Heart disease 1 | 279
Hypertension 1 | 293
Inflammation 1 | 109
Kidney Diseases 1 | 86
Kidney disease 1 | 397
Leber congenital amaurosis 1 | 72
Liver Cirrhosis, Experimental 1 | 108
Malignant tumor of ovary 1 | 25
Melanoma 1 | 261
Non-alcoholic Fatty Liver Disease 1 | 40
Paralysed 1 | 9
Peripheral Neuropathy 1 | 303
Retinal Degeneration 1 | 49
Severe Combined Immunodeficiency 1 | 46
Squamous cell carcinoma 1 | 96
Stevens-Johnson syndrome 1 | 91
Stomach Neoplasms 1 | 282
Toxic encephalopathy 1 | 131
facioscapulohumeral dystrophy 1 | 286
head and neck cancer 1 | 270
interstitial lung disease 1 | 292
non-small cell lung carcinoma 1 | 413
permanent atrial fibrillation 1 | 44
systemic lupus erythematosus 1 | 172

Tissue

Blood and immune system 16 | 17,995
Cardiovascular System 16 | 17,958
Digestive Tract 16 | 18,473
Endocrine System 16 | 18,512
Female tissues 16 | 18,647
Liver and Pancreas 16 | 18,136
Male tissues 16 | 17,969
Nervous System 16 | 18,561
Respiratory system 16 | 17,484
Skin and soft tissues 16 | 18,115
Urinary Tract 16 | 18,444

Target Family

Enzyme 7 | 4,146
Epigenetic 7 | 242
Kinase 2 | 634

WikiPathways Pathway

NAD+ metabolism 16 | 16
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
NAD-dependent protein deacylase sirtuin-5, mitochondrial SIRT5 Tbio Epigenetic -2.31270 198.8 379
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial SIRT4 Tchem Epigenetic -2.06691 115.1 229
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 CD38 Tclin Enzyme -3.42346 2528.3 1207
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 NMNAT3 Tbio Enzyme -1.31063 18.9 116
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 NMNAT2 Tbio Enzyme -1.49231 31.0 94
NAD-dependent protein deacetylase sirtuin-2 SIRT2 Tchem Epigenetic -2.79974 642.8 351
5'-nucleotidase NT5E Tchem Enzyme -2.83818 696.3 655
Poly [ADP-ribose] polymerase 1 PARP1 Tclin Enzyme -3.68565 4494.4 1272
Nik-related protein kinase NRK Tdark Kinase -0.21967 2.00 29
NAD-dependent protein deacetylase sirtuin-1 SIRT1 Tchem Epigenetic -3.43962 2958.6 656