Development Level

Tchem 7 | 1,598
Tbio 6 | 11,445
Tclin 2 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

abnormal gait 2 | 69
preweaning lethality, incomple... 2 | 499
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal brain morphology 1 | 13
abnormal embryo size 1 | 220
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal neural tube morpholog... 1 | 12
abnormal retinal inner nuclear... 1 | 8
abnormal skin morphology 1 | 50
decreased total retina thickne... 1 | 17
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hydroencephaly 1 | 14
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
pale yolk sac 1 | 25
preweaning lethality, complete... 1 | 979

Disease

Cancer 11 | 2,499
osteosarcoma 11 | 7,950
diabetes mellitus 10 | 1,728
Carcinoma 9 | 11,493
ovarian cancer 9 | 8,520
Obesity 8 | 678
medulloblastoma, large-cell 8 | 6,241
glioblastoma 6 | 5,792
psoriasis 6 | 6,694
atypical teratoid / rhabdoid tumor 5 | 5,112
lung cancer 5 | 4,740
astrocytic glioma 4 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
Arthritis 3 | 290
Astrocytoma, Pilocytic 3 | 3,081
Atherosclerosis 3 | 291
Fatty liver disease 3 | 103
Liver Cirrhosis, Experimental 3 | 769
Multiple myeloma 3 | 1,332
Vascular disease 3 | 319
adrenocortical carcinoma 3 | 1,428
adult high grade glioma 3 | 3,801
cutaneous lupus erythematosus 3 | 1,057
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
group 4 medulloblastoma 3 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
invasive ductal carcinoma 3 | 2,951
lung carcinoma 3 | 2,843
malignant mesothelioma 3 | 3,232
primitive neuroectodermal tumor 3 | 3,035
tuberculosis 3 | 2,010
Anemia 2 | 365
Breast Neoplasms 2 | 445
Breast cancer 2 | 3,578
Cardiomegaly 2 | 116
Ceroid lipofuscinosis, neuronal 1, infantile 2 | 10
Chronic Lymphocytic Leukemia 2 | 262
Colitis 2 | 54
Colorectal Neoplasms 2 | 243
Fatty Liver 2 | 70
Huntington's disease 2 | 76
Mammary Neoplasms 2 | 425
Mood Disorders 2 | 184
Mouth Neoplasms 2 | 55
Neurodegenerative disease 2 | 414
Parkinson's disease 2 | 392
Pick disease 2 | 1,894
Pneumonia 2 | 174
Polycystic ovary syndrome 2 | 360
Prostatic Neoplasms 2 | 495
Schizophrenia 2 | 1,160
Scleroderma, Systemic 2 | 13
Systemic scleroderma 2 | 60
Toxic encephalopathy 2 | 141
Waldenstrons macroglobulinemia 2 | 765
Wallerian Degeneration 2 | 4
axial spondyloarthropathy 2 | 28
cystic fibrosis 2 | 1,696
ductal carcinoma in situ 2 | 1,745
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung adenocarcinoma 2 | 2,716
non-small cell lung cancer 2 | 2,890
pancreatic cancer 2 | 2,398
primary Sjogren syndrome 2 | 735
subependymal giant cell astrocytoma 2 | 2,287
ulcerative colitis 2 | 1,819
Acute kidney injury 1 | 70
Arts syndrome 1 | 26
Barrett's esophagus 1 | 182
Brain Injuries 1 | 65
COPD 1 | 118
Carcinoma in situ of fallopian tube 1 | 4
Carcinoma, Squamous Cell 1 | 110
Diabetes Mellitus, Experimental 1 | 108
Diphtheria 1 | 40
Fibrosis 1 | 44
Fundus dystrophy 1 | 83
Glucose Intolerance 1 | 19
HIV Infections 1 | 102
Impaired glucose tolerance 1 | 28
Insulin Resistance 1 | 72
Leber congenital amaurosis 1 | 69
Malignant epithelial tumor of ovary 1 | 5
Malignant tumor of ovary 1 | 25
Malignant tumor of peritoneum 1 | 6
Metabolic syndrome X 1 | 52
Nerve Degeneration 1 | 121
Neurodegenerative Disorders 1 | 79
Non-alcoholic Fatty Liver Disease 1 | 42
Paralysed 1 | 42
Paralysis 1 | 9
Parkinsonian Disorders 1 | 56
Pseudoxanthoma elasticum 1 | 18
Squamous cell carcinoma 1 | 129
Stevens-Johnson syndrome 1 | 92
inflammatory breast cancer 1 | 286
interstitial lung disease 1 | 298
non-small cell lung carcinoma 1 | 317

Tissue

Cardiovascular System 16 | 15,192
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Respiratory system 16 | 16,393
Skin and soft tissues 16 | 17,230
Urinary Tract 16 | 16,678
Blood and immune system 15 | 16,909
Nervous System 15 | 16,725

Target Family

Enzyme 7 | 4,145
Epigenetic 7 | 242
Kinase 2 | 634

WikiPathways Pathway

NAD+ metabolism 16 | 16
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
NAD-dependent protein deacylase sirtuin-5, mitochondrial SIRT5 Tchem Epigenetic -2.36015 219.3 427
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 CD38 Tclin Enzyme -3.44680 2663.1 1493
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 NMNAT2 Tbio Enzyme -1.54038 36.0 111
NAD kinase NADK Tbio Kinase -1.49880 29.8 98
NAD-dependent protein deacetylase sirtuin-7 SIRT7 Tbio Epigenetic -2.22094 153.0 348
Nicotinamide phosphoribosyltransferase NAMPT Tchem Enzyme -2.94790 1054.3 667
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 NMNAT3 Tbio Enzyme -1.31765 20.1 141
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial SIRT4 Tbio Epigenetic -2.14139 133.9 254
NAD-dependent protein deacetylase sirtuin-2 SIRT2 Tchem Epigenetic -2.83863 706.1 386
NAD-dependent protein deacetylase sirtuin-1 SIRT1 Tchem Epigenetic -3.50639 3413.7 733