Development Level

Tbio 83 | 11,178
Tchem 56 | 1,885
Tclin 17 | 612
Tdark 3 | 6,569

Collection

Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Complete... 1 | 25
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

increased startle reflex 7 | 112
preweaning lethality, incomple... 7 | 499
embryonic lethality prior to t... 6 | 278
preweaning lethality, complete... 6 | 979
abnormal bone structure 4 | 187
increased circulating alkaline... 4 | 122
increased heart weight 4 | 62
abnormal behavior 3 | 298
abnormal retina morphology 3 | 71
decreased total body fat amoun... 3 | 207
decreased vertical activity 3 | 208
abnormal embryo size 2 | 220
decreased body weight 2 | 161
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 46
decreased circulating choleste... 2 | 93
decreased circulating sodium l... 2 | 22
decreased prepulse inhibition 2 | 82
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
hyperactivity 2 | 148
increased circulating iron lev... 2 | 30
increased erythrocyte cell num... 2 | 39
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
small testis 2 | 58
thrombocytopenia 2 | 56
abnormal bone mineralization 1 | 38
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal digit morphology 1 | 10
abnormal ear morphology 1 | 9
abnormal facial morphology 1 | 17
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal retinal vasculature m... 1 | 27
abnormal sensory capabilities-... 1 | 8
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
abnormal testis morphology 1 | 43
abnormal urinary bladder morph... 1 | 11
cardiovascular system phenotyp... 1 | 36
decreased IgE level 1 | 6
decreased IgG3 level 1 | 1
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating free fat... 1 | 31
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
edema 1 | 59
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating lipase l... 1 | 3
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
male infertility 1 | 123
pallor 1 | 34
prolonged PR interval 1 | 15
small epididymis 1 | 3
small kidney 1 | 16
small superior vagus ganglion 1 | 74
urinary bladder obstruction 1 | 4

Disease

Carcinoma 93 | 11,192
medulloblastoma, large-cell 89 | 6,086
glioblastoma 83 | 5,635
osteosarcoma 79 | 7,766
ovarian cancer 78 | 8,297
ependymoma 70 | 4,559
psoriasis 70 | 6,514
atypical teratoid / rhabdoid tumor 66 | 4,971
adult high grade glioma 61 | 3,701
lung cancer 59 | 4,607
Astrocytoma, Pilocytic 54 | 3,006
primitive neuroectodermal tumor 54 | 2,957
astrocytic glioma 49 | 2,530
lung adenocarcinoma 48 | 2,627
Breast cancer 47 | 3,469
group 3 medulloblastoma 47 | 4,002
oligodendroglioma 47 | 2,768
lung carcinoma 46 | 2,755
malignant mesothelioma 45 | 3,135
pancreatic cancer 41 | 2,322
intraductal papillary-mucinous carcinoma (IPMC) 40 | 2,902
non-small cell lung cancer 40 | 2,799
Cancer 39 | 2,388
group 4 medulloblastoma 36 | 1,806
pituitary cancer 36 | 1,915
Schizophrenia 35 | 1,136
intraductal papillary-mucinous neoplasm (IPMN) 35 | 3,204
invasive ductal carcinoma 35 | 2,867
intraductal papillary-mucinous adenoma (IPMA) 34 | 2,872
subependymal giant cell astrocytoma 34 | 2,230
ulcerative colitis 34 | 1,765
Kidney cancer 33 | 2,548
Pick disease 32 | 1,856
interstitial cystitis 32 | 2,237
tuberculosis 28 | 1,963
Bipolar Disorder 27 | 646
Depressive disorder 26 | 401
Hypertension 26 | 372
colon cancer 26 | 1,428
diabetes mellitus 25 | 1,683
cystic fibrosis 23 | 1,629
breast carcinoma 22 | 1,589
Obesity 21 | 655
Rheumatoid arthritis 21 | 1,156
acute quadriplegic myopathy 21 | 1,133
Heart disease 18 | 288
Mental Depression 18 | 325
dermatomyositis 18 | 941
Hypertensive disease 17 | 278
Liver Cirrhosis, Experimental 17 | 733
ductal carcinoma in situ 17 | 1,686
Seizures 16 | 584
juvenile dermatomyositis 16 | 1,147
Down syndrome 15 | 480
Kidney disease 15 | 411
Major Depressive Disorder 15 | 293
Unipolar Depression 15 | 244
active ulcerative colitis 15 | 736
primary pancreatic ductal adenocarcinoma 15 | 1,071
Alcoholic Intoxication, Chronic 14 | 283
Alzheimer's disease 14 | 640
Epilepsy 14 | 775
Intellectual disability 14 | 998
Liver cancer 14 | 589
Multiple myeloma 14 | 1,296
adrenocortical carcinoma 14 | 1,385
Cerebrovascular disease 13 | 223
Duchenne muscular dystrophy 13 | 587
aldosterone-producing adenoma 13 | 646
autosomal dominant Emery-Dreifuss muscular dystrophy 13 | 492
pancreatic carcinoma 13 | 555
Autosomal recessive predisposition 12 | 1,407
Mood Disorders 12 | 181
Waldenstrons macroglobulinemia 12 | 742
active Crohn's disease 12 | 882
astrocytoma 12 | 1,113
hepatocellular carcinoma 12 | 536
pediatric high grade glioma 12 | 1,035
Autistic Disorder 11 | 358
Crohn's disease 11 | 311
Prostatic Neoplasms 11 | 472
non primary Sjogren syndrome sicca 11 | 861
primary Sjogren syndrome 11 | 710
spina bifida 11 | 1,053
Adenoma 10 | 159
Carney complex 10 | 24
Hyperalgesia 10 | 80
Myocardial Infarction 10 | 142
Osteoporosis 10 | 348
Parkinson's disease 10 | 378
head and neck cancer 10 | 263
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,911
Asthma 9 | 370
Atopic dermatitis 9 | 915
Cushing's syndrome 9 | 47
Diabetes Mellitus, Experimental 9 | 101
Myocardial Ischemia 9 | 162
atypical teratoid/rhabdoid tumor 9 | 349
cutaneous lupus erythematosus 9 | 1,016
gastric cancer 9 | 445

Tissue

Endocrine System 155 | 18,159
Blood and immune system 153 | 16,909
Digestive Tract 153 | 17,369
Skin and soft tissues 153 | 17,230
Female tissues 152 | 17,400
Male tissues 151 | 17,142
Nervous System 150 | 16,725
Liver and Pancreas 149 | 16,750
Urinary Tract 148 | 16,678
Respiratory system 146 | 16,393
Cardiovascular System 140 | 15,192

Target Family

Non-IDG 79 | 12,091
Enzyme 29 | 4,145
Kinase 19 | 634
Transcription Factor 15 | 1,400
GPCR 7 | 408
Ion Channel 7 | 344
Transporter 3 | 473

WikiPathways Pathway

Myometrial Relaxation and Cont... 159 | 159
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ryanodine receptor 1 RYR1 Tclin Ion Channel -3.00978 1018.9 103
Serine/threonine-protein kinase D1 PRKD1 Tchem Kinase -2.88440 775.2 667
Adenylate cyclase type 3 ADCY3 Tbio Enzyme -2.31593 204.4 82
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 GNG7 Tbio Non-IDG -0.76260 5.38 63
Guanylate cyclase activator 2B GUCA2B Tbio Enzyme -1.30745 23.3 137
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 GNG12 Tbio Non-IDG -0.39851 2.26 42
Insulin-like growth factor-binding protein 2 IGFBP2 Tchem Non-IDG -2.93237 835.0 335
Ryanodine receptor 3 RYR3 Tclin Ion Channel -2.15460 142.3 16
Regulator of G-protein signaling 17 RGS17 Tbio Non-IDG -1.36519 22.6 111
Cyclic AMP-dependent transcription factor ATF-5 ATF5 Tbio Transcription Factor -1.80759 80.3 220