Development Level

Tbio 82 | 10,625
Tchem 57 | 1,890
Tclin 14 | 602
Tdark 4 | 7,003

Collection

Eligible Ion Channel Proteins 2 | 117
Eligible Kinase Proteins 2 | 134

IMPC Term

embryonic lethality prior to t... 6 | 187
abnormal bone mineralization 5 | 55
increased circulating alkaline... 5 | 119
abnormal bone structure 4 | 131
increased heart weight 4 | 37
preweaning lethality, incomple... 4 | 260
abnormal behavior 3 | 226
preweaning lethality, complete... 3 | 633
abnormal embryo size 2 | 112
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal neural tube closure 2 | 37
decreased body weight 2 | 174
decreased circulating sodium l... 2 | 18
decreased grip strength 2 | 123
decreased lean body mass 2 | 195
decreased prepulse inhibition 2 | 52
decreased total body fat amoun... 2 | 186
increased circulating iron lev... 2 | 25
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular vol... 2 | 91
male infertility 2 | 62
small testis 2 | 37
thrombocytopenia 2 | 46
abnormal coat/hair pigmentatio... 1 | 54
abnormal cornea morphology 1 | 24
abnormal lens morphology 1 | 73
abnormal liver morphology 1 | 5
abnormal lung morphology 1 | 15
abnormal midbrain development 1 | 22
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal sensory capabilities/... 1 | 3
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 23
abnormal testis morphology 1 | 30
abnormal urinary bladder morph... 1 | 2
cardiovascular system phenotyp... 1 | 35
decreased B cell number 1 | 30
decreased IgE level 1 | 3
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 19
decreased thermal nociceptive ... 1 | 4
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
hydrops fetalis 1 | 22
hyperactivity 1 | 108
hypoactivity 1 | 89
increased IgG1 level 1 | 1
increased T cell number 1 | 15
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating calcium ... 1 | 32
increased circulating chloride... 1 | 43
increased circulating free fat... 1 | 17
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 26
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased monocyte cell number 1 | 27
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 57
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82
small epididymis 1 | 3
small kidney 1 | 10
small superior vagus ganglion 1 | 20
urinary bladder obstruction 1 | 2

Disease

medulloblastoma, large-cell 94 | 6,234
glioblastoma 86 | 5,572
ovarian cancer 82 | 8,484
osteosarcoma 81 | 7,933
psoriasis 76 | 6,685
atypical teratoid / rhabdoid tumor 63 | 4,369
pilocytic astrocytoma 58 | 3,086
lung cancer 57 | 4,466
primitive neuroectodermal tumor 56 | 3,031
lung adenocarcinoma 53 | 2,713
malignant mesothelioma 50 | 3,162
lung carcinoma 49 | 2,844
oligodendroglioma 49 | 2,849
pediatric high grade glioma 46 | 2,712
ulcerative colitis 46 | 2,087
Cancer 44 | 2,346
ependymoma 44 | 2,514
non-small cell lung cancer 44 | 2,798
pancreatic cancer 44 | 2,300
intraductal papillary-mucinous carcinoma (IPMC) 43 | 2,988
pituitary cancer 43 | 1,972
astrocytic glioma 40 | 2,241
Breast cancer 39 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 38 | 2,956
invasive ductal carcinoma 38 | 2,950
interstitial cystitis 36 | 2,299
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,289
group 4 medulloblastoma 35 | 1,875
subependymal giant cell astrocytoma 33 | 2,287
adult high grade glioma 32 | 2,148
Pick disease 31 | 1,893
Carcinoma 29 | 2,147
cystic fibrosis 29 | 1,665
colon cancer 28 | 1,475
medulloblastoma 27 | 1,524
breast carcinoma 26 | 1,614
Obesity 25 | 616
astrocytoma 25 | 1,493
Rheumatoid Arthritis 23 | 1,160
diabetes mellitus 23 | 1,663
posterior fossa group A ependymoma 23 | 1,511
acute quadriplegic myopathy 22 | 1,157
group 3 medulloblastoma 21 | 2,254
tuberculosis 21 | 1,557
Hypertension 20 | 287
Schizophrenia 20 | 501
adrenocortical carcinoma 20 | 1,427
dermatomyositis 20 | 933
primary pancreatic ductal adenocarcinoma 20 | 1,271
ductal carcinoma in situ 19 | 1,745
juvenile dermatomyositis 18 | 1,189
Down syndrome 17 | 548
posterior fossa group B ependymoma 17 | 1,530
atypical teratoid/rhabdoid tumor 16 | 1,095
Duchenne muscular dystrophy 15 | 602
Kidney disease 15 | 396
Multiple myeloma 15 | 1,327
aldosterone-producing adenoma 15 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 499
Heart disease 14 | 279
Prostatic Neoplasms 14 | 471
active Crohn's disease 14 | 918
hepatocellular carcinoma 14 | 532
Alzheimer's disease 13 | 644
Waldenstrons macroglobulinemia 13 | 765
pancreatic carcinoma 13 | 567
primary Sjogren syndrome 13 | 789
sonic hedgehog group medulloblastoma 13 | 1,482
Cerebrovascular disease 12 | 231
Hypertensive disease 12 | 193
gastric carcinoma 12 | 832
spina bifida 12 | 1,064
Crohn's disease 11 | 304
Diabetes Mellitus, Non-Insulin-Dependent 11 | 157
Parkinson's disease 11 | 364
non primary Sjogren syndrome sicca 11 | 840
Adenoma 10 | 165
Atopic dermatitis 10 | 944
Autistic Disorder 10 | 320
Bipolar Disorder 10 | 266
Carney complex 10 | 23
Diabetes Mellitus, Experimental 10 | 106
Myocardial Ischemia 10 | 169
head and neck cancer 10 | 270
tuberculosis and treatment for 3 months 10 | 327
Cushing's syndrome 9 | 47
Endometriosis 9 | 535
Mammary Neoplasms 9 | 410
Myocardial Infarction 9 | 126
Osteoporosis 9 | 257
Pain agnosia 9 | 99
Seizures 9 | 95
cutaneous lupus erythematosus 9 | 1,056
inflammatory breast cancer 9 | 404
sarcoidosis 9 | 358
urothelial carcinoma 9 | 318
esophageal adenocarcinoma 8 | 737
gastric cancer 8 | 430
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
periodontitis 8 | 269

Tissue

Digestive Tract 155 | 18,473
Endocrine System 155 | 18,512
Female tissues 155 | 18,647
Liver and Pancreas 155 | 18,136
Nervous System 155 | 18,561
Urinary Tract 155 | 18,444
Blood and immune system 154 | 17,995
Cardiovascular System 154 | 17,958
Male tissues 154 | 17,969
Respiratory system 153 | 17,484
Skin and soft tissues 153 | 18,115

Target Family

Non-IDG 77 | 11,971
Enzyme 29 | 4,146
Kinase 19 | 634
Transcription Factor 15 | 1,400
GPCR 7 | 406
Ion Channel 7 | 341
Transporter 3 | 473

WikiPathways Pathway

Myometrial Relaxation and Cont... 157 | 157
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Cyclic AMP-responsive element-binding protein 3 CREB3 Tbio Transcription Factor -1.61736 42.0 159
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 PLCD1 Tchem Enzyme -2.16125 137.5 96
Regulator of G-protein signaling 16 RGS16 Tbio Non-IDG -1.59717 42.2 162
Adenylate cyclase type 1 ADCY1 Tchem Enzyme -1.58202 42.2 123
Regulator of G-protein signaling 5 RGS5 Tbio Non-IDG -1.60212 47.5 222
ADM ADM Tchem Non-IDG -3.25380 1832.5 293