Development Level

Tbio 18 | 10,625
Tchem 18 | 1,890
Tclin 4 | 602

IMPC Term

decreased body weight 3 | 174
decreased circulating creatini... 2 | 31
decreased circulating triglyce... 2 | 83
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal rib morphology 1 | 28
abnormal spinal cord morpholog... 1 | 8
absent heartbeat 1 | 6
cataract 1 | 26
decreased B cell number 1 | 30
decreased NK cell number 1 | 16
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating aspartat... 1 | 27
decreased circulating bilirubi... 1 | 14
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating magnesiu... 1 | 11
decreased circulating serum al... 1 | 79
decreased grip strength 1 | 123
decreased lumbar vertebrae num... 1 | 62
decreased lymphocyte cell numb... 1 | 9
decreased mature B cell number 1 | 25
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged lymph nodes 1 | 27
fusion of vertebral arches 1 | 7
impaired righting response 1 | 19
increased IgG1 level 1 | 1
increased T cell number 1 | 15
increased bone mineral content 1 | 92
increased eosinophil cell numb... 1 | 9
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased neutrophil cell numb... 1 | 15
increased red blood cell distr... 1 | 21
increased rib number 1 | 41
increased spleen weight 1 | 3
persistence of hyaloid vascula... 1 | 22
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260
stereotypic behavior 1 | 3
trunk curl 1 | 15
vertebral fusion 1 | 23

Disease

osteosarcoma 27 | 7,933
ovarian cancer 27 | 8,492
invasive ductal carcinoma 25 | 2,950
interstitial cystitis 24 | 2,299
lung cancer 22 | 4,473
lung carcinoma 22 | 2,844
glioblastoma 21 | 5,572
subependymal giant cell astrocytoma 20 | 2,287
cutaneous lupus erythematosus 19 | 1,056
ulcerative colitis 18 | 2,087
medulloblastoma, large-cell 17 | 6,234
pilocytic astrocytoma 17 | 3,086
Cancer 16 | 2,346
psoriasis 16 | 6,685
non-small cell lung cancer 15 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,956
tuberculosis 13 | 1,563
Carcinoma 12 | 2,147
diabetes mellitus 12 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,289
pancreatic cancer 12 | 2,300
pediatric high grade glioma 12 | 2,712
primary Sjogren syndrome 12 | 789
astrocytoma 11 | 1,493
juvenile dermatomyositis 11 | 1,189
IGA Glomerulonephritis 10 | 454
adrenocortical carcinoma 10 | 1,427
head and neck cancer and chronic obstructive pulmonary disease 10 | 237
malignant mesothelioma 9 | 3,163
Waldenstrons macroglobulinemia 8 | 765
atypical teratoid / rhabdoid tumor 8 | 4,369
Duchenne muscular dystrophy 7 | 602
adult high grade glioma 7 | 2,148
gastric carcinoma 7 | 832
group 3 medulloblastoma 7 | 2,254
lung adenocarcinoma 7 | 2,714
mucosa-associated lymphoid tissue lymphoma 7 | 480
Breast cancer 6 | 3,099
cystic fibrosis 6 | 1,670
dermatomyositis 6 | 967
esophageal adenocarcinoma 6 | 737
medulloblastoma 6 | 1,524
posterior fossa group A ependymoma 6 | 1,511
Chronic granulomatous disease 5 | 13
Kidney disease 5 | 397
colon cancer 5 | 1,475
ductal carcinoma in situ 5 | 1,745
group 4 medulloblastoma 5 | 1,875
periodontitis 5 | 269
Arthritis 4 | 248
Becker muscular dystrophy 4 | 187
Diffuse large B-cell lymphoma 4 | 42
Down syndrome 4 | 548
Hypertension 4 | 293
Hypertensive disease 4 | 193
Liver diseases 4 | 66
Lupus erythematosus 4 | 80
Multiple myeloma 4 | 1,328
acute myeloid leukemia 4 | 785
acute quadriplegic myopathy 4 | 1,157
breast carcinoma 4 | 1,614
chronic lymphosyte leukemia 4 | 232
inflammatory breast cancer 4 | 404
nasopharyngeal carcinoma 4 | 1,056
nephrosclerosis 4 | 329
primary pancreatic ductal adenocarcinoma 4 | 1,271
primitive neuroectodermal tumor 4 | 3,031
spina bifida 4 | 1,064
systemic lupus erythematosus 4 | 172
Asthma 3 | 349
Atherosclerosis 3 | 275
Barrett's esophagus 3 | 185
C1q DEFICIENCY 3 | 3
Calcinosis 3 | 63
Cerebrovascular disease 3 | 231
Cherubism 3 | 14
Complement component C1q deficiency 3 | 3
Diabetes Mellitus, Experimental 3 | 106
Heart Diseases 3 | 42
Heart disease 3 | 279
Heart failure 3 | 80
Heart valve disease 3 | 24
Kidney Failure, Chronic 3 | 45
Melanoma 3 | 261
Multiple Sclerosis 3 | 498
Pneumonia 3 | 133
Prostatic Neoplasms 3 | 471
Rheumatoid Arthritis 3 | 1,171
Schizophrenia 3 | 503
active Crohn's disease 3 | 918
ependymoma 3 | 2,514
limb girdle muscular dystrophy 2A 3 | 156
pituitary cancer 3 | 1,972
Pick disease 2 | 1,893
Vascular disease 2 | 281
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
limb girdle muscular dystrophy 2I 2 | 56
pancreatic carcinoma 2 | 567
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795

Tissue

Blood and immune system 40 | 17,995
Cardiovascular System 40 | 17,958
Digestive Tract 40 | 18,473
Female tissues 40 | 18,647
Male tissues 40 | 17,969
Nervous System 40 | 18,561
Respiratory system 40 | 17,484
Urinary Tract 40 | 18,444
Endocrine System 39 | 18,512
Liver and Pancreas 39 | 18,136
Skin and soft tissues 39 | 18,115

Target Family

Non-IDG 20 | 11,969
Kinase 10 | 634
Enzyme 9 | 4,146
Ion Channel 1 | 341

WikiPathways Pathway

Microglia Pathogen Phagocytosi... 40 | 40
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related C3 botulinum toxin substrate 2 RAC2 Tchem Enzyme -2.87547 633.7 216
Guanine nucleotide exchange factor VAV2 VAV2 Tbio Non-IDG -1.78476 58.3 173
Guanine nucleotide exchange factor VAV3 VAV3 Tbio Non-IDG -1.78968 69.0 206
Linker for activation of T-cells family member 1 LAT Tchem Non-IDG -2.15070 165.9 570
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.49806 301.3 641
TYRO protein tyrosine kinase-binding protein TYROBP Tbio Enzyme -2.30132 203.5 188
Phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3C3 Tchem Kinase -2.29900 181.8 641
Cytochrome b-245 light chain CYBA Tbio Non-IDG -2.56763 358.8 154
Complement C1q subcomponent subunit C C1QC Tbio Non-IDG -1.27627 17.5 141
Complement C1q subcomponent subunit B C1QB Tbio Non-IDG -1.65078 41.3 161