Development Level

Tbio 24 | 11,445
Tchem 11 | 1,598
Tclin 5 | 613

IMPC Phenotype

decreased body weight 3 | 161
decreased circulating amylase ... 2 | 28
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased hemoglobin content 2 | 68
increased lean body mass 2 | 172
increased spleen weight 2 | 10
increased total body fat amoun... 2 | 134
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
cataract 1 | 92
decreased IgG3 level 1 | 1
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
fusion of vertebral arches 1 | 7
impaired righting response 1 | 26
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating amylase ... 1 | 25
increased erythrocyte cell num... 1 | 39
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
persistence of hyaloid vascula... 1 | 33
stereotypic behavior 1 | 3
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56
trunk curl 1 | 16
vertebral fusion 1 | 23

Disease

Carcinoma 27 | 11,493
osteosarcoma 27 | 7,950
ovarian cancer 27 | 8,520
invasive ductal carcinoma 25 | 2,951
interstitial cystitis 24 | 2,312
glioblastoma 23 | 5,792
lung cancer 22 | 4,740
lung carcinoma 22 | 2,843
subependymal giant cell astrocytoma 20 | 2,287
cutaneous lupus erythematosus 19 | 1,057
Cancer 18 | 2,499
Astrocytoma, Pilocytic 17 | 3,081
medulloblastoma, large-cell 17 | 6,241
psoriasis 16 | 6,694
ulcerative colitis 16 | 1,819
non-small cell lung cancer 15 | 2,890
Liver Cirrhosis, Experimental 14 | 769
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
tuberculosis 14 | 2,010
adult high grade glioma 13 | 3,801
diabetes mellitus 12 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
pancreatic cancer 12 | 2,398
primary Sjogren syndrome 12 | 735
Autosomal recessive predisposition 11 | 1,442
Schizophrenia 11 | 1,160
juvenile dermatomyositis 11 | 1,187
adrenocortical carcinoma 10 | 1,428
astrocytoma 10 | 1,146
head and neck cancer and chronic obstructive pulmonary disease 10 | 239
Breast cancer 9 | 3,578
Kidney cancer 9 | 2,613
group 3 medulloblastoma 9 | 4,104
malignant mesothelioma 9 | 3,232
Waldenstrons macroglobulinemia 8 | 765
atypical teratoid / rhabdoid tumor 8 | 5,112
Duchenne muscular dystrophy 7 | 601
cystic fibrosis 7 | 1,696
gastric carcinoma 7 | 807
lung adenocarcinoma 7 | 2,716
mucosa-associated lymphoid tissue lymphoma 7 | 484
Systemic lupus erythematosus 6 | 194
dermatomyositis 6 | 966
ependymoma 6 | 4,679
esophageal adenocarcinoma 6 | 737
group 4 medulloblastoma 6 | 1,855
pediatric high grade glioma 6 | 1,064
periodontitis 6 | 293
Arthritis 5 | 290
Chronic granulomatous disease 5 | 13
Fever 5 | 138
Hyperpigmented macules 5 | 42
Hypertension 5 | 396
Kidney disease 5 | 430
Malabsorption 5 | 82
Melanoma 5 | 711
Paranasal Sinus Diseases 5 | 34
Recurrent respiratory infections 5 | 141
Sinusitis 5 | 65
Splenomegaly 5 | 190
breast carcinoma 5 | 1,638
colon cancer 5 | 1,478
ductal carcinoma in situ 5 | 1,745
Becker muscular dystrophy 4 | 191
Chronic Obstructive Airway Disease 4 | 37
Diffuse large B-cell lymphoma 4 | 39
Down syndrome 4 | 499
Epilepsy 4 | 792
Hepatomegaly 4 | 285
Hypertensive disease 4 | 292
Immunologic Deficiency Syndromes 4 | 113
Liver diseases 4 | 87
Lymphadenopathy 4 | 62
Lymphoma, Large B-Cell, Diffuse 4 | 34
Mediastinal lymphadenopathy 4 | 10
Multiple myeloma 4 | 1,332
Neutrophil abnormality 4 | 20
Otitis Media 4 | 52
Perirectal abscess 4 | 5
Photosensitivity of skin 4 | 51
Pyloric Stenosis 4 | 47
Rectal abscess 4 | 5
Recurrent infections 4 | 48
Seizures 4 | 596
Tracheoesophageal Fistula 4 | 36
active ulcerative colitis 4 | 764
acute myeloid leukemia 4 | 783
acute quadriplegic myopathy 4 | 1,158
follicular lymphoma 4 | 20
limb girdle muscular dystrophy 2A 4 | 213
nasopharyngeal carcinoma 4 | 1,058
nephrosclerosis 4 | 333
posterior fossa group A ependymoma 4 | 468
primitive neuroectodermal tumor 4 | 3,035
spina bifida 4 | 1,074
Alzheimer's disease 3 | 658
Depressive disorder 3 | 409
active Crohn's disease 3 | 922
chronic lymphosyte leukemia 3 | 204

Tissue

Blood and immune system 40 | 16,909
Cardiovascular System 40 | 15,192
Digestive Tract 40 | 17,369
Endocrine System 40 | 18,159
Female tissues 40 | 17,400
Liver and Pancreas 40 | 16,750
Male tissues 40 | 17,142
Nervous System 40 | 16,725
Respiratory system 40 | 16,393
Skin and soft tissues 40 | 17,230
Urinary Tract 40 | 16,678

Target Family

Non-IDG 20 | 12,091
Kinase 10 | 634
Enzyme 9 | 4,145
Ion Channel 1 | 344

WikiPathways Pathway

Microglia Pathogen Phagocytosi... 40 | 40
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Linker for activation of T-cells family member 1 LAT Tbio Non-IDG -2.16291 169.4 667
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
Cytochrome b-245 heavy chain CYBB Tchem Ion Channel -3.09698 1276.8 315
Complement C1q subcomponent subunit A C1QA Tbio Non-IDG -1.73823 51.2 241
Triggering receptor expressed on myeloid cells 1 TREM1 Tbio Non-IDG -2.50690 350.6 473
Integrin alpha-M ITGAM Tbio Non-IDG -3.63427 3939.5 2165
Ras-related C3 botulinum toxin substrate 3 RAC3 Tbio Enzyme -0.30344 1.49 56
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha PIK3C2A Tchem Kinase -3.50398 3129.0 525
Tyrosine-protein kinase HCK HCK Tclin Kinase -3.53517 3192.7 428
Neutrophil cytosol factor 4 NCF4 Tbio Non-IDG -2.45708 273.9 346