Development Level

Tchem 37 | 1,598
Tbio 27 | 11,445
Tclin 17 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, incomple... 6 | 499
preweaning lethality, complete... 5 | 979
decreased body weight 3 | 161
decreased circulating creatini... 3 | 39
abnormal bone mineralization 2 | 38
abnormal retina morphology 2 | 71
decreased circulating LDL chol... 2 | 38
decreased circulating glucose ... 2 | 126
decreased mean corpuscular hem... 2 | 31
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased bone mineral density 2 | 72
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased mean corpuscular hem... 2 | 96
increased total body fat amoun... 2 | 134
abnormal cornea morphology 1 | 31
abnormal duodenum morphology 1 | 4
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
abnormal startle reflex 1 | 15
abnormal vocalization 1 | 21
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased granulocyte number 1 | 6
decreased hematocrit 1 | 46
decreased mean corpuscular vol... 1 | 79
decreased thermal nociceptive ... 1 | 2
edema 1 | 59
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
limb grasping 1 | 41
male infertility 1 | 123
mammalian phenotype 1 | 17
shortened RR interval 1 | 17
thrombocytosis 1 | 27

Disease

Carcinoma 62 | 11,493
Cancer 58 | 2,499
osteosarcoma 47 | 7,950
ovarian cancer 46 | 8,520
glioblastoma 45 | 5,792
atypical teratoid / rhabdoid tumor 37 | 5,112
medulloblastoma, large-cell 37 | 6,241
ependymoma 34 | 4,679
psoriasis 34 | 6,694
lung cancer 33 | 4,740
adult high grade glioma 31 | 3,801
Breast cancer 26 | 3,578
Kidney cancer 26 | 2,613
malignant mesothelioma 26 | 3,232
diabetes mellitus 25 | 1,728
Astrocytoma, Pilocytic 23 | 3,081
Schizophrenia 22 | 1,160
primitive neuroectodermal tumor 20 | 3,035
Depressive disorder 19 | 409
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
subependymal giant cell astrocytoma 19 | 2,287
group 3 medulloblastoma 18 | 4,104
tuberculosis 18 | 2,010
Cardiomegaly 17 | 116
Heart disease 17 | 306
interstitial cystitis 17 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
invasive ductal carcinoma 17 | 2,951
non-small cell lung cancer 17 | 2,890
oligodendroglioma 17 | 2,850
Kidney disease 16 | 430
Obesity 16 | 678
astrocytic glioma 16 | 2,597
pancreatic cancer 16 | 2,398
Hypertension 15 | 396
Intellectual disability 15 | 1,016
Lung Neoplasms 15 | 232
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
Autosomal recessive predisposition 14 | 1,442
Breast Neoplasms 14 | 445
Mammary Neoplasms 14 | 425
Mental Depression 14 | 333
Vascular disease 14 | 319
cystic fibrosis 14 | 1,696
lung carcinoma 14 | 2,843
ulcerative colitis 14 | 1,819
Alzheimer's disease 13 | 658
Arthritis 13 | 290
Cognitive delay 13 | 608
Dull intelligence 13 | 645
Global developmental delay 13 | 608
Low intelligence 13 | 645
Mental Retardation 13 | 645
Mental and motor retardation 13 | 608
Mental deficiency 13 | 645
Multiple myeloma 13 | 1,332
Pick disease 13 | 1,894
Poor school performance 13 | 645
Prostatic Neoplasms 13 | 495
group 4 medulloblastoma 13 | 1,855
lung adenocarcinoma 13 | 2,716
Frontal bossing 12 | 157
Hyperglycemia 12 | 137
Hypertensive disease 12 | 292
Hypoplastic mandible condyle 12 | 275
Lung disease 12 | 142
Mandibular hypoplasia 12 | 275
Micrognathism 12 | 275
Neoplasm Metastasis 12 | 168
Orbital separation excessive 12 | 244
Osteoporosis 12 | 363
Seizures 12 | 596
Short stature 12 | 531
breast carcinoma 12 | 1,638
juvenile dermatomyositis 12 | 1,187
Asthma 11 | 385
Bipolar Disorder 11 | 666
Epilepsy 11 | 792
Heart failure 11 | 162
Rheumatoid arthritis 11 | 1,191
Stomach Neoplasms 11 | 300
pituitary cancer 11 | 1,972
Big calvaria 10 | 147
Cardiomyopathies 10 | 110
Cell Transformation, Neoplastic 10 | 97
Cerebrovascular disease 10 | 238
Coronary artery disease 10 | 268
Increased head circumference 10 | 147
Increased size of cranium 10 | 147
Increased size of skull 10 | 147
Liver Cirrhosis, Experimental 10 | 769
Myocardial Ischemia 10 | 169
Neoplasm Invasiveness 10 | 161
Neoplastic Cell Transformation 10 | 89
Polycystic ovary syndrome 10 | 360
Reperfusion Injury 10 | 86
Small head 10 | 374
ductal carcinoma in situ 9 | 1,745
spina bifida 9 | 1,074

Tissue

Digestive Tract 81 | 17,369
Female tissues 81 | 17,400
Male tissues 81 | 17,142
Respiratory system 81 | 16,393
Blood and immune system 80 | 16,909
Endocrine System 80 | 18,159
Liver and Pancreas 80 | 16,750
Cardiovascular System 79 | 15,192
Skin and soft tissues 79 | 17,230
Urinary Tract 79 | 16,678
Nervous System 78 | 16,725

Target Family

Kinase 41 | 634
Non-IDG 23 | 12,091
Enzyme 8 | 4,145
Epigenetic 4 | 242
Transcription Factor 4 | 1,400
GPCR 2 | 408

WikiPathways Pathway

MicroRNAs in cardiomyocyte hyp... 82 | 82
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone deacetylase 9 HDAC9 Tclin Epigenetic -2.27309 185.2 431
Nuclear factor of activated T-cells, cytoplasmic 4 NFATC4 Tbio Transcription Factor -1.93766 88.3 358
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform PPP3CB Tbio Enzyme -1.53531 28.2 147
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Leukemia inhibitory factor LIF Tbio Non-IDG -2.86943 538.7 413
Phospholipase A2, membrane associated PLA2G2A Tchem Enzyme -2.83666 743.3 137
Low-density lipoprotein receptor-related protein 5 LRP5 Tbio Non-IDG -3.10429 1247.5 302
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.14048 137.8 104