Development Level

Tbio 14 | 11,445
Tchem 7 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased body length 2 | 101
embryonic lethality prior to o... 2 | 239
male infertility 2 | 123
abnormal behavior 1 | 298
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating glucose ... 1 | 126
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased food intake 1 | 13
decreased granulocyte number 1 | 6
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
embryonic lethality prior to t... 1 | 278
female infertility 1 | 60
increased blood urea nitrogen ... 1 | 48
increased lean body mass 1 | 172
increased startle reflex 1 | 112

Disease

ovarian cancer 14 | 8,520
Carcinoma 11 | 11,493
medulloblastoma, large-cell 11 | 6,241
osteosarcoma 10 | 7,950
psoriasis 10 | 6,694
Cancer 6 | 2,499
Multiple myeloma 6 | 1,332
lung adenocarcinoma 6 | 2,716
pancreatic cancer 6 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
invasive ductal carcinoma 5 | 2,951
Autosomal recessive predisposition 4 | 1,442
Dull intelligence 4 | 645
Homocystinuria 4 | 21
Intellectual disability 4 | 1,016
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Poor school performance 4 | 645
atypical teratoid / rhabdoid tumor 4 | 5,112
group 4 medulloblastoma 4 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
lung cancer 4 | 4,740
lung carcinoma 4 | 2,843
malignant mesothelioma 4 | 3,232
non-small cell lung cancer 4 | 2,890
spina bifida 4 | 1,074
tuberculosis 4 | 2,010
Bipolar Disorder 3 | 666
Breast cancer 3 | 3,578
Cleft Palate 3 | 271
Hyperhomocysteinemia 3 | 37
Hypermethioninemia 3 | 11
Schizophrenia 3 | 1,160
Secondary progressive multiple sclerosis 3 | 10
Sleeping sickness 3 | 37
acute quadriplegic myopathy 3 | 1,158
astrocytic glioma 3 | 2,597
dermatomyositis 3 | 966
diabetes mellitus 3 | 1,728
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
hepatocellular carcinoma 3 | 547
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
oligodendroglioma 3 | 2,850
primary pancreatic ductal adenocarcinoma 3 | 1,109
primitive neuroectodermal tumor 3 | 3,035
Adenocarcinoma of lung 2 | 142
Amino Acid Metabolism, Inborn Errors 2 | 13
Astrocytoma, Pilocytic 2 | 3,081
Atopic dermatitis 2 | 952
Cleft Lip 2 | 141
Cognitive delay 2 | 608
Coronary artery disease 2 | 268
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Disease Models, Animal 2 | 155
Down syndrome 2 | 499
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Global developmental delay 2 | 608
Hepatic methionine adenosyltransferase deficiency 2 | 7
Hepatolenticular Degeneration 2 | 24
Leishmaniasis 2 | 47
Mental and motor retardation 2 | 608
Muscle hypotonia 2 | 571
Pediatric failure to thrive 2 | 365
Polycystic ovary syndrome 2 | 360
Prostatic Neoplasms 2 | 495
Seizures 2 | 596
Vascular disease 2 | 319
adrenocortical carcinoma 2 | 1,428
breast carcinoma 2 | 1,638
chronic rhinosinusitis 2 | 512
cystic fibrosis 2 | 1,696
ductal carcinoma in situ 2 | 1,745
gastric carcinoma 2 | 807
glioblastoma 2 | 5,792
inflammatory breast cancer 2 | 286
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
medulloblastoma 2 | 720
nephrosclerosis 2 | 333
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
progressive supranuclear palsy 2 | 676
ulcerative colitis 2 | 1,819
Adult respiratory distress syndrome 1 | 3
Broad-based gait 1 | 19
Carcinoma of colon 1 | 32
Central nervous system demyelination 1 | 28
Chromosome 17q11.2 deletion syndrome, 1.4Mb 1 | 15
Dyskeratosis congenita 1 | 24
Fatty Liver 1 | 70
Hearing Loss 1 | 17
Mastitis 1 | 48
Nevus 1 | 19
Palmoplantar keratosis 1 | 74
Poor coordination 1 | 11
Tall stature 1 | 34

Tissue

Digestive Tract 22 | 17,369
Endocrine System 22 | 18,159
Female tissues 22 | 17,400
Liver and Pancreas 22 | 16,750
Nervous System 22 | 16,725
Skin and soft tissues 22 | 17,230
Urinary Tract 22 | 16,678
Blood and immune system 21 | 16,909
Male tissues 21 | 17,142
Respiratory system 21 | 16,393
Cardiovascular System 20 | 15,192

Target Family

Enzyme 21 | 4,145
Non-IDG 1 | 12,091

WikiPathways Pathway

Methionine De Novo and Salvage... 22 | 22
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
L-amino-acid oxidase IL4I1 Tbio Enzyme -2.79074 622.3 53
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase ADI1 Tbio Enzyme -2.05198 103.3 194
Methylthioribose-1-phosphate isomerase MRI1 Tbio Enzyme -2.37285 221.6 146
Methionine synthase MTR Tbio Enzyme -2.56900 300.2 87
Mitochondrial peptide methionine sulfoxide reductase MSRA Tbio Enzyme -1.92325 88.1 167
S-adenosylmethionine decarboxylase proenzyme AMD1 Tchem Enzyme -3.21826 1586.8 141
Spermine synthase SMS Tchem Enzyme -1.50353 28.6 215
Choline dehydrogenase, mitochondrial CHDH Tbio Enzyme -1.44261 27.1 85
Spermidine synthase SRM Tchem Enzyme -1.65951 38.0 172
S-adenosylmethionine synthase isoform type-2 MAT2A Tbio Enzyme -1.91969 84.1 242