Development Level

Tbio 112 | 11,445
Tchem 35 | 1,598
Tdark 13 | 6,588
Tclin 12 | 613

Collection

Ion Channel: IDG Consortium (T... 2 | 99

IMPC Phenotype

hypoactivity 4 | 132
preweaning lethality, complete... 4 | 979
abnormal behavior 3 | 298
decreased circulating phosphat... 3 | 27
decreased total body fat amoun... 3 | 207
hyperactivity 3 | 148
increased circulating alkaline... 3 | 122
increased startle reflex 3 | 112
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal vibrissa morphology 2 | 25
cataract 2 | 92
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased lean body mass 2 | 135
decreased mean corpuscular vol... 2 | 79
improved glucose tolerance 2 | 79
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
small kidney 2 | 16
abnormal clavicle morphology 1 | 6
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal fibula morphology 1 | 2
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal locomotor behavior 1 | 24
abnormal male genitalia morpho... 1 | 3
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal retina morphology 1 | 71
abnormal rib morphology 1 | 10
abnormal scapula morphology 1 | 3
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
absent external male genitalia 1 | 1
absent mammary gland 1 | 1
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean platelet volume 1 | 25
decreased pulmonary respirator... 1 | 5
decreased skeletal muscle mass 1 | 1
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged spleen 1 | 41
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
increased IgA level 1 | 1
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating unsatura... 1 | 1
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
oligodactyly 1 | 1
persistence of hyaloid vascula... 1 | 33
polydactyly 1 | 7
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small heart 1 | 10
small ovary 1 | 1
small spleen 1 | 19
small uterus 1 | 3
thin skin 1 | 2
thrombocytopenia 1 | 56

Disease

Carcinoma 114 | 11,493
psoriasis 78 | 6,694
ovarian cancer 60 | 8,520
glioblastoma 50 | 5,792
medulloblastoma, large-cell 49 | 6,241
Cancer 48 | 2,499
osteosarcoma 46 | 7,950
ependymoma 44 | 4,679
lung cancer 43 | 4,740
atypical teratoid / rhabdoid tumor 39 | 5,112
lung carcinoma 39 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 36 | 1,962
group 3 medulloblastoma 34 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 34 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 33 | 3,291
interstitial cystitis 32 | 2,312
non-small cell lung cancer 32 | 2,890
Astrocytoma, Pilocytic 31 | 3,081
malignant mesothelioma 31 | 3,232
adult high grade glioma 30 | 3,801
Breast cancer 29 | 3,578
Prostatic Neoplasms 29 | 495
tuberculosis 27 | 2,010
invasive ductal carcinoma 25 | 2,951
lung adenocarcinoma 25 | 2,716
oligodendroglioma 25 | 2,850
primitive neuroectodermal tumor 24 | 3,035
pituitary cancer 23 | 1,972
Autosomal recessive predisposition 22 | 1,442
pancreatic cancer 22 | 2,398
Chemical and Drug Induced Liver Injury 20 | 195
Schizophrenia 20 | 1,160
adrenocortical carcinoma 20 | 1,428
cystic fibrosis 20 | 1,696
ductal carcinoma in situ 20 | 1,745
astrocytic glioma 19 | 2,597
ulcerative colitis 19 | 1,819
colon cancer 16 | 1,478
cutaneous lupus erythematosus 14 | 1,057
subependymal giant cell astrocytoma 14 | 2,287
Endometriosis 13 | 540
fibroadenoma 13 | 559
Breast Neoplasms 12 | 445
Cholestasis 12 | 155
Hypertension 12 | 396
Liver Cirrhosis, Experimental 12 | 769
Liver disease 12 | 237
Mammary Neoplasms 12 | 425
Pick disease 12 | 1,894
group 4 medulloblastoma 12 | 1,855
Epilepsy 11 | 792
aldosterone-producing adenoma 11 | 665
astrocytoma 11 | 1,146
breast carcinoma 11 | 1,638
diabetes mellitus 11 | 1,728
esophageal adenocarcinoma 11 | 737
head and neck cancer and chronic obstructive pulmonary disease 11 | 239
nephrosclerosis 11 | 333
Alcoholic Intoxication, Chronic 10 | 289
Anemia 10 | 365
Kidney cancer 10 | 2,613
Rheumatoid arthritis 10 | 1,191
active Crohn's disease 10 | 922
acute quadriplegic myopathy 10 | 1,158
pediatric high grade glioma 10 | 1,064
Atopic dermatitis 9 | 952
Carcinoma, Hepatocellular 9 | 228
Contact Dermatitis 9 | 81
Dermatitis, Contact 9 | 71
Failure to gain weight 9 | 365
Liver carcinoma 9 | 240
Lung Neoplasms 9 | 232
Melanoma 9 | 711
Osteoporosis 9 | 363
Pediatric failure to thrive 9 | 365
Polycystic ovary syndrome 9 | 360
nasopharyngeal carcinoma 9 | 1,058
non primary Sjogren syndrome sicca 9 | 891
Acute kidney injury 8 | 70
Bipolar Disorder 8 | 666
Congenital adrenal hyperplasia 8 | 73
Drug-Related Side Effects and Adverse Reactions 8 | 62
Hypertensive disease 8 | 292
Intellectual disability 8 | 1,016
Neurodegenerative Diseases 8 | 38
Neurodegenerative Disorders 8 | 79
Obesity 8 | 678
Sickle Cell Anemia 8 | 53
chronic rhinosinusitis 8 | 512
Bladder Neoplasm 7 | 112
Delayed bone age 7 | 136
Depressive disorder 7 | 409
Multiple myeloma 7 | 1,332
Muscle hypotonia 7 | 571
active ulcerative colitis 7 | 764
juvenile dermatomyositis 7 | 1,187
medulloblastoma 7 | 720
non diabetic and post-ischemic heart failure 7 | 200
substance-related disorder 7 | 162

Tissue

Digestive Tract 164 | 17,369
Endocrine System 160 | 18,159
Female tissues 160 | 17,400
Liver and Pancreas 158 | 16,750
Skin and soft tissues 156 | 17,230
Male tissues 154 | 17,142
Urinary Tract 152 | 16,678
Blood and immune system 147 | 16,909
Nervous System 139 | 16,725
Respiratory system 135 | 16,393
Cardiovascular System 108 | 15,192

Target Family

Enzyme 141 | 4,145
Non-IDG 28 | 12,091
Ion Channel 3 | 344

WikiPathways Pathway

Metapathway biotransformation ... 172 | 172
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cholesterol 24-hydroxylase CYP46A1 Tbio Enzyme -1.84856 68.6 197
Heparan sulfate glucosamine 3-O-sulfotransferase 4 HS3ST4 Tdark Enzyme -0.45852 2.98 18
Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 Tbio Enzyme -0.79764 6.35 32
Galactose-3-O-sulfotransferase 4 GAL3ST4 Tdark Enzyme -0.48192 3.06 142
Heparan sulfate glucosamine 3-O-sulfotransferase 6 HS3ST6 Tdark Enzyme -0.31878 2.19 19
UDP-glucuronosyltransferase 2B7 UGT2B7 Tchem Enzyme -2.31570 219.0 131
Cytochrome P450 26A1 CYP26A1 Tchem Enzyme -2.44772 290.1 197
Carbohydrate sulfotransferase 2 CHST2 Tbio Enzyme -1.29443 20.9 188
N-acetyltransferase 14 NAT14 Tbio Enzyme -1.00750 8.01 80
Cytochrome P450 4Z1 CYP4Z1 Tbio Non-IDG -0.68998 9.87 74