Development Level

Tbio 110 | 11,445
Tchem 25 | 1,598
Tdark 8 | 6,588
Tclin 4 | 613

IMPC Phenotype

preweaning lethality, complete... 18 | 979
preweaning lethality, incomple... 8 | 499
embryonic lethality prior to t... 7 | 278
abnormal embryo size 6 | 220
abnormal bone structure 5 | 187
embryonic lethality prior to o... 5 | 239
decreased prepulse inhibition 4 | 82
enlarged heart 4 | 210
increased bone mineral density 4 | 72
increased lean body mass 4 | 172
microphthalmia 4 | 26
abnormal craniofacial morpholo... 3 | 33
abnormal heart morphology 3 | 162
abnormal tooth morphology 3 | 24
corneal opacity 3 | 32
decreased body weight 3 | 161
decreased lean body mass 3 | 135
decreased total body fat amoun... 3 | 207
hypoactivity 3 | 132
increased heart weight 3 | 62
increased mean corpuscular vol... 3 | 92
increased monocyte cell number 3 | 63
increased or absent threshold ... 3 | 101
increased total body fat amoun... 3 | 134
abnormal bone mineralization 2 | 38
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal limb morphology 2 | 13
abnormal retina morphology 2 | 71
anophthalmia 2 | 33
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating choleste... 2 | 93
decreased circulating glycerol... 2 | 16
decreased erythrocyte cell num... 2 | 62
decreased mean corpuscular vol... 2 | 79
decreased startle reflex 2 | 75
decreased vertical activity 2 | 208
increased bone mineral content 2 | 108
prenatal lethality 2 | 28
abnormal behavioral response t... 1 | 66
abnormal body wall morphology 1 | 9
abnormal cornea morphology 1 | 31
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal eye anterior chamber ... 1 | 9
abnormal facial morphology 1 | 17
abnormal head shape 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal optic disc morphology 1 | 10
abnormal response to new envir... 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal sleep behavior 1 | 70
abnormal urinary bladder morph... 1 | 11
abnormal whole-body plethysmog... 1 | 4
absent startle reflex 1 | 24
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased mature B cell number 1 | 7
dilated heart left ventricle 1 | 11
edema 1 | 59
hydrometra 1 | 53
increased B cell number 1 | 9
increased T cell number 1 | 6
increased aggression 1 | 4
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased circulating potassiu... 1 | 29
increased fasted circulating g... 1 | 76
increased lactate dehydrogenas... 1 | 3
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
increased total retina thickne... 1 | 4
long tibia 1 | 25
prolonged PR interval 1 | 15
short tibia 1 | 97
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

Carcinoma 110 | 11,493
ovarian cancer 80 | 8,520
osteosarcoma 76 | 7,950
Cancer 66 | 2,499
psoriasis 66 | 6,694
lung cancer 60 | 4,740
medulloblastoma, large-cell 60 | 6,241
glioblastoma 58 | 5,792
Breast cancer 52 | 3,578
atypical teratoid / rhabdoid tumor 52 | 5,112
malignant mesothelioma 49 | 3,232
group 3 medulloblastoma 41 | 4,104
ependymoma 39 | 4,679
invasive ductal carcinoma 39 | 2,951
lung adenocarcinoma 38 | 2,716
Kidney cancer 37 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 35 | 3,291
primitive neuroectodermal tumor 34 | 3,035
interstitial cystitis 29 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,989
non-small cell lung cancer 29 | 2,890
adult high grade glioma 28 | 3,801
oligodendroglioma 28 | 2,850
breast carcinoma 26 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,955
lung carcinoma 26 | 2,843
group 4 medulloblastoma 25 | 1,855
ulcerative colitis 25 | 1,819
cystic fibrosis 24 | 1,696
pancreatic cancer 24 | 2,398
Astrocytoma, Pilocytic 23 | 3,081
Intellectual disability 22 | 1,016
astrocytic glioma 22 | 2,597
colon cancer 21 | 1,478
ductal carcinoma in situ 21 | 1,745
pituitary cancer 21 | 1,972
Breast Neoplasms 20 | 445
subependymal giant cell astrocytoma 19 | 2,287
Mammary Neoplasms 18 | 425
Short stature 17 | 531
tuberculosis 17 | 2,010
Dull intelligence 16 | 645
Low intelligence 16 | 645
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Pick disease 16 | 1,894
Poor school performance 16 | 645
adrenocortical carcinoma 16 | 1,428
diabetes mellitus 16 | 1,728
pediatric high grade glioma 16 | 1,064
Craniofacial Abnormalities 15 | 151
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
spina bifida 15 | 1,074
Cognitive delay 14 | 608
Cryptorchidism 14 | 296
Global developmental delay 14 | 608
Mental and motor retardation 14 | 608
Schizophrenia 14 | 1,160
acute quadriplegic myopathy 14 | 1,158
cutaneous lupus erythematosus 14 | 1,057
primary pancreatic ductal adenocarcinoma 14 | 1,109
Cleft Palate 13 | 271
Orbital separation excessive 13 | 244
juvenile dermatomyositis 13 | 1,187
Autosomal recessive predisposition 12 | 1,442
Epilepsy 12 | 792
Liver cancer 12 | 604
Muscle hypotonia 12 | 571
Rheumatoid arthritis 12 | 1,191
astrocytoma 12 | 1,146
esophageal adenocarcinoma 12 | 737
gastric carcinoma 12 | 807
Failure to gain weight 11 | 365
Pediatric failure to thrive 11 | 365
Prostatic Neoplasms 11 | 495
Seizures 11 | 596
Waldenstrons macroglobulinemia 11 | 765
nasopharyngeal carcinoma 11 | 1,058
Alzheimer's disease 10 | 658
Congenital heart disease 10 | 93
Holoprosencephaly 10 | 56
Hypoplastic mandible condyle 10 | 275
Mandibular hypoplasia 10 | 275
Micrognathism 10 | 275
Obesity 10 | 678
Osteoporosis 10 | 363
Polycystic ovary syndrome 10 | 360
Strabismus 10 | 270
dermatomyositis 10 | 966
Acquired scoliosis 9 | 281
Curvature of spine 9 | 282
Liver Cirrhosis, Experimental 9 | 769
Multiple myeloma 9 | 1,332
Parkinson's disease 9 | 392
Stomach Neoplasms 9 | 300
Ventricular Septal Defects 9 | 119
acute myeloid leukemia 9 | 783
primary Sjogren syndrome 9 | 735
Congenital hypoplasia of penis 8 | 176
Small head 8 | 374

Tissue

Endocrine System 145 | 18,159
Skin and soft tissues 142 | 17,230
Female tissues 141 | 17,400
Digestive Tract 140 | 17,369
Male tissues 139 | 17,142
Nervous System 139 | 16,725
Blood and immune system 138 | 16,909
Urinary Tract 138 | 16,678
Liver and Pancreas 137 | 16,750
Respiratory system 137 | 16,393
Cardiovascular System 130 | 15,192

Target Family

Transcription Factor 54 | 1,400
Non-IDG 53 | 12,091
Enzyme 14 | 4,145
Kinase 10 | 634
Epigenetic 7 | 242
GPCR 3 | 408
Nuclear Receptor 3 | 48
Transporter 2 | 473
TF/Epigenetic 1 | 38

WikiPathways Pathway

Mesodermal Commitment Pathway 147 | 147
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor SOX-21 SOX21 Tbio Transcription Factor -1.47198 29.1 106
Huntingtin HTT Tchem Non-IDG -3.36282 2294.8 599
Eomesodermin homolog EOMES Tbio Transcription Factor -2.37902 230.4 333
T-box transcription factor TBX6 TBX6 Tbio Transcription Factor -1.78720 63.0 315
Condensin-2 complex subunit G2 NCAPG2 Tbio Non-IDG -0.75957 5.48 110
Transcriptional-regulating factor 1 TRERF1 Tbio Transcription Factor -0.69436 6.18 146
Forkhead box protein C2 FOXC2 Tbio Transcription Factor -2.23435 187.0 419
MBT domain-containing protein 1 MBTD1 Tdark Epigenetic -0.59314 4.06 83
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 DDAH1 Tchem Enzyme -2.13636 144.4 205
Sestrin-1 SESN1 Tbio Non-IDG -1.95681 82.0 172