Development Level

Tchem 28 | 1,598
Tbio 16 | 11,445
Tclin 10 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 3 | 125
RFA-RM-18-021 3 | 328

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased body weight 3 | 161
preweaning lethality, incomple... 3 | 499
decreased circulating creatini... 2 | 39
increased circulating alkaline... 2 | 122
short tibia 2 | 97
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
increased blood urea nitrogen ... 1 | 48
increased caudal vertebrae num... 1 | 7
increased circulating LDL chol... 1 | 13
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased heart left ventricle... 1 | 4
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
prenatal lethality 1 | 28
thrombocytosis 1 | 27

Disease

Carcinoma 46 | 11,493
ovarian cancer 43 | 8,520
Cancer 40 | 2,499
osteosarcoma 36 | 7,950
glioblastoma 31 | 5,792
medulloblastoma, large-cell 28 | 6,241
atypical teratoid / rhabdoid tumor 27 | 5,112
Breast cancer 25 | 3,578
lung cancer 25 | 4,740
psoriasis 25 | 6,694
ependymoma 23 | 4,679
Kidney cancer 21 | 2,613
oligodendroglioma 17 | 2,850
Byzanthine arch palate 16 | 194
Orbital separation excessive 16 | 244
adult high grade glioma 16 | 3,801
Blepharoptosis 15 | 231
Short stature 15 | 531
group 4 medulloblastoma 15 | 1,855
Acquired scoliosis 14 | 281
Curvature of spine 14 | 282
Muscle hypotonia 14 | 571
Schizophrenia 14 | 1,160
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
Astrocytoma, Pilocytic 13 | 3,081
Downward slant of palpebral fissure 13 | 158
Intellectual disability 13 | 1,016
astrocytic glioma 13 | 2,597
juvenile dermatomyositis 13 | 1,187
Cognitive delay 12 | 608
Concave bridge of nose 12 | 195
Cryptorchidism 12 | 296
Depressed nasal bridge 12 | 195
Depressed nasal root/bridge 12 | 195
Dull intelligence 12 | 645
Global developmental delay 12 | 608
High forehead 12 | 102
Hypoplastic mandible condyle 12 | 275
Joint hyperflexibility 12 | 78
Low intelligence 12 | 645
Mandibular hypoplasia 12 | 275
Mental Retardation 12 | 645
Mental and motor retardation 12 | 608
Mental deficiency 12 | 645
Micrognathism 12 | 275
Multiple myeloma 12 | 1,332
Noonan syndrome 12 | 34
Pectus excavatum 12 | 100
Poor school performance 12 | 645
Stomach Neoplasms 12 | 300
Strabismus 12 | 270
Tall forehead 12 | 102
group 3 medulloblastoma 12 | 4,104
pancreatic cancer 12 | 2,398
subependymal giant cell astrocytoma 12 | 2,287
Breast Neoplasms 11 | 445
Carcinoma, Squamous Cell 11 | 110
Epilepsy 11 | 792
Frontal bossing 11 | 157
Mammary Neoplasms 11 | 425
Neck webbing 11 | 35
Renal Cell Carcinoma 11 | 214
Rheumatoid arthritis 11 | 1,191
Seizures 11 | 596
Squamous cell carcinoma 11 | 129
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
invasive ductal carcinoma 11 | 2,951
non-small cell lung cancer 11 | 2,890
primitive neuroectodermal tumor 11 | 3,035
ulcerative colitis 11 | 1,819
Abnormal dermatoglyphic pattern 10 | 24
Big calvaria 10 | 147
Congenital Epicanthus 10 | 177
Increased head circumference 10 | 147
Increased size of cranium 10 | 147
Increased size of skull 10 | 147
Large auricle 10 | 87
Large dysplastic ears 10 | 87
Large pinnae 10 | 87
Large prominent ears 10 | 87
Large protruding ears 10 | 87
Large, floppy ears 10 | 87
Lung Neoplasms 10 | 232
Macrotia 10 | 87
Melanoma 10 | 711
Short neck 10 | 140
Triangular face 10 | 58
diabetes mellitus 10 | 1,728
tuberculosis 10 | 2,010
Carcinoma, Hepatocellular 9 | 228
Cardiac Arrhythmia 9 | 103
Delayed bone age 9 | 136
Feeding difficulties in infancy 9 | 175
Liver carcinoma 9 | 240
Low-set, posteriorly rotated ears 9 | 110
Pick disease 9 | 1,894
Ventricular Septal Defects 9 | 119
breast carcinoma 9 | 1,638
lung adenocarcinoma 9 | 2,716

Tissue

Digestive Tract 55 | 17,369
Endocrine System 55 | 18,159
Female tissues 55 | 17,400
Liver and Pancreas 55 | 16,750
Male tissues 55 | 17,142
Nervous System 55 | 16,725
Respiratory system 55 | 16,393
Skin and soft tissues 55 | 17,230
Urinary Tract 55 | 16,678
Blood and immune system 54 | 16,909
Cardiovascular System 54 | 15,192

Target Family

Kinase 26 | 634
Enzyme 13 | 4,145
Non-IDG 13 | 12,091
Transcription Factor 3 | 1,400

WikiPathways Pathway

MET in type 1 papillary renal ... 55 | 55
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
ALK tyrosine kinase receptor ALK Tclin Kinase -3.44312 2942.9 976
Rap guanine nucleotide exchange factor 1 RAPGEF1 Tbio Non-IDG -2.41980 281.2 167
Elongin-A ELOA Tbio Non-IDG -1.28526 22.1 289
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114