Development Level

Tbio 121 | 11,651
Tchem 92 | 1,388
Tclin 24 | 612
Tdark 8 | 6,593

Collection

RFA-RM-18-021 19 | 328
Ion Channel: IDG Consortium (T... 14 | 99
Kinase: IDG Consortium (Target... 5 | 125
Kinase: IDG Consortium (Comple... 3 | 37

IMPC Phenotype

preweaning lethality, complete... 21 | 979
abnormal bone structure 10 | 187
embryonic lethality prior to t... 6 | 278
abnormal behavior 5 | 298
abnormal embryo size 5 | 220
decreased body weight 5 | 161
decreased total body fat amoun... 5 | 207
increased circulating alkaline... 5 | 122
increased circulating choleste... 5 | 66
decreased bone mineral content 4 | 151
decreased circulating choleste... 4 | 93
decreased circulating glucose ... 4 | 126
decreased circulating sodium l... 4 | 22
decreased lean body mass 4 | 135
increased circulating sodium l... 4 | 71
increased startle reflex 4 | 112
preweaning lethality, incomple... 4 | 499
abnormal cornea morphology 3 | 31
abnormal lens morphology 3 | 81
abnormal retina morphology 3 | 71
cataract 3 | 92
decreased circulating triglyce... 3 | 79
decreased fasted circulating g... 3 | 65
decreased grip strength 3 | 116
decreased neutrophil cell numb... 3 | 42
embryonic lethality prior to o... 3 | 239
increased bone mineral content 3 | 108
increased circulating HDL chol... 3 | 80
increased or absent threshold ... 3 | 101
increased total body fat amoun... 3 | 134
short tibia 3 | 97
abnormal bone mineralization 2 | 38
abnormal coat-hair pigmentatio... 2 | 64
abnormal gait 2 | 69
abnormal optic disc morphology 2 | 10
abnormal retinal vasculature m... 2 | 27
abnormal rib morphology 2 | 10
abnormal startle reflex 2 | 15
corneal opacity 2 | 32
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating alanine ... 2 | 47
decreased circulating creatini... 2 | 39
decreased circulating fructosa... 2 | 30
decreased circulating serum al... 2 | 82
decreased hematocrit 2 | 46
decreased prepulse inhibition 2 | 82
decreased spleen weight 2 | 10
decreased vertical activity 2 | 208
edema 2 | 59
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
hemorrhage 2 | 23
impaired pupillary reflex 2 | 26
increased body length 2 | 32
increased bone mineral density 2 | 72
increased circulating free fat... 2 | 20
increased circulating glucose ... 2 | 24
increased circulating triglyce... 2 | 42
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
limb grasping 2 | 41
male infertility 2 | 123
prenatal lethality 2 | 28
thrombocytopenia 2 | 56
abnormal body wall morphology 1 | 9
abnormal cranium morphology 1 | 36
abnormal joint morphology 1 | 23
abnormal neural tube closure 1 | 46
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating potassiu... 1 | 20
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased circulating alanine ... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased lactate dehydrogenas... 1 | 3
increased mean corpuscular vol... 1 | 92
iris synechia 1 | 3
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
shortened RR interval 1 | 17
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Carcinoma 179 | 11,493
ovarian cancer 128 | 8,520
glioblastoma 125 | 5,792
osteosarcoma 121 | 7,950
Cancer 113 | 2,499
medulloblastoma, large-cell 109 | 6,241
psoriasis 107 | 6,694
atypical teratoid / rhabdoid tumor 105 | 5,112
ependymoma 97 | 4,679
lung cancer 95 | 4,740
adult high grade glioma 81 | 3,801
malignant mesothelioma 78 | 3,232
Breast cancer 77 | 3,578
Astrocytoma, Pilocytic 70 | 3,081
oligodendroglioma 66 | 2,850
group 3 medulloblastoma 65 | 4,104
primitive neuroectodermal tumor 60 | 3,035
Kidney cancer 58 | 2,613
Schizophrenia 56 | 1,160
lung carcinoma 55 | 2,843
subependymal giant cell astrocytoma 54 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 52 | 3,291
astrocytic glioma 49 | 2,597
invasive ductal carcinoma 48 | 2,951
pancreatic cancer 48 | 2,398
group 4 medulloblastoma 46 | 1,855
Pick disease 45 | 1,894
non-small cell lung cancer 44 | 2,890
diabetes mellitus 42 | 1,728
ulcerative colitis 42 | 1,819
tuberculosis 41 | 2,010
intraductal papillary-mucinous adenoma (IPMA) 39 | 2,955
lung adenocarcinoma 39 | 2,716
pituitary cancer 39 | 1,972
interstitial cystitis 38 | 2,312
cystic fibrosis 36 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 36 | 2,989
Depressive disorder 35 | 409
Epilepsy 34 | 792
Bipolar Disorder 33 | 666
Intellectual disability 32 | 1,016
Rheumatoid arthritis 32 | 1,191
astrocytoma 32 | 1,146
Vascular disease 30 | 319
colon cancer 30 | 1,478
Lung Neoplasms 29 | 232
Parkinson's disease 28 | 392
Short stature 28 | 531
adrenocortical carcinoma 28 | 1,428
Breast Neoplasms 27 | 445
Mammary Neoplasms 27 | 425
primary pancreatic ductal adenocarcinoma 27 | 1,109
Orbital separation excessive 26 | 244
Seizures 26 | 596
Mental Depression 25 | 333
ductal carcinoma in situ 25 | 1,745
Alzheimer's disease 24 | 658
Autosomal recessive predisposition 24 | 1,442
pancreatic ductal adenocarcinoma liver metastasis 24 | 1,962
Acquired scoliosis 23 | 281
Byzanthine arch palate 23 | 194
Curvature of spine 23 | 282
breast carcinoma 23 | 1,638
Cryptorchidism 22 | 296
Downward slant of palpebral fissure 22 | 158
Dull intelligence 22 | 645
Low intelligence 22 | 645
Mental Retardation 22 | 645
Mental deficiency 22 | 645
Poor school performance 22 | 645
juvenile dermatomyositis 22 | 1,187
Cleft Palate 21 | 271
Melanoma 21 | 711
Multiple myeloma 21 | 1,332
dermatomyositis 21 | 966
pediatric high grade glioma 21 | 1,064
Arthritis 20 | 290
Blepharoptosis 20 | 231
Hypoplastic mandible condyle 20 | 275
Liver Cirrhosis, Experimental 20 | 769
Mandibular hypoplasia 20 | 275
Micrognathism 20 | 275
Osteoporosis 20 | 363
cutaneous lupus erythematosus 20 | 1,057
Hypertensive disease 19 | 292
Obesity 19 | 678
Prostatic Neoplasms 19 | 495
Stomach Neoplasms 19 | 300
Toxic encephalopathy 19 | 141
acute quadriplegic myopathy 19 | 1,158
Carcinoma, Hepatocellular 18 | 228
Concave bridge of nose 18 | 195
Depressed nasal bridge 18 | 195
Depressed nasal root/bridge 18 | 195
Endometriosis 18 | 540
Heart disease 18 | 306
Liver carcinoma 18 | 240
Lung disease 18 | 142
Strabismus 18 | 270
Muscle hypotonia 17 | 571

Tissue

Endocrine System 244 | 18,159
Digestive Tract 237 | 17,369
Nervous System 236 | 16,725
Blood and immune system 234 | 16,909
Female tissues 234 | 17,400
Male tissues 234 | 17,142
Skin and soft tissues 233 | 17,230
Urinary Tract 230 | 16,678
Liver and Pancreas 226 | 16,750
Respiratory system 226 | 16,393
Cardiovascular System 214 | 15,192

Target Family

Non-IDG 78 | 12,091
Kinase 76 | 634
Enzyme 45 | 4,145
Ion Channel 26 | 344
Transcription Factor 19 | 1,400
Nuclear Receptor 1 | 48

WikiPathways Pathway

MAPK Signaling Pathway 245 | 245
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Tyrosine-protein phosphatase non-receptor type 5 PTPN5 Tchem Enzyme -1.85420 70.8 225
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Voltage-dependent calcium channel gamma-2 subunit CACNG2 Tbio Ion Channel -1.92203 89.6 173
Cyclic AMP-dependent transcription factor ATF-2 ATF2 Tbio Transcription Factor -2.23104 170.7 1819
Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D Tclin Ion Channel -2.43448 273.2 215