Development Level

Tchem 96 | 1,890
Tbio 59 | 10,625
Tclin 11 | 602
Tdark 1 | 7,003

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 12 | 633
abnormal bone structure 6 | 131
decreased total body fat amoun... 5 | 186
embryonic lethality prior to t... 5 | 187
decreased body weight 4 | 174
decreased lean body mass 4 | 195
increased circulating alkaline... 4 | 119
abnormal embryo size 3 | 112
abnormal lens morphology 3 | 73
abnormal retina morphology 3 | 100
decreased circulating sodium l... 3 | 18
embryonic lethality prior to o... 3 | 148
increased circulating choleste... 3 | 53
increased lean body mass 3 | 107
increased or absent threshold ... 3 | 128
abnormal behavior 2 | 226
abnormal coat/hair pigmentatio... 2 | 54
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal neural tube closure 2 | 37
abnormal retinal pigmentation 2 | 61
decreased body length 2 | 108
decreased bone mineral content 2 | 157
decreased caudal vertebrae num... 2 | 49
decreased circulating alanine ... 2 | 53
decreased circulating choleste... 2 | 85
decreased circulating glucose ... 2 | 121
decreased circulating triglyce... 2 | 83
decreased fasted circulating g... 2 | 49
decreased leukocyte cell numbe... 2 | 54
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular hem... 2 | 19
decreased rib number 2 | 59
decreased thoracic vertebrae n... 2 | 7
increased blood urea nitrogen ... 2 | 44
increased body length 2 | 20
increased body weight 2 | 42
increased bone mineral content 2 | 92
increased circulating HDL chol... 2 | 63
increased circulating iron lev... 2 | 25
increased circulating phosphat... 2 | 24
increased erythrocyte cell num... 2 | 26
increased prepulse inhibition 2 | 21
male infertility 2 | 62
small superior vagus ganglion 2 | 20
thrombocytopenia 2 | 46
abnormal coat/ hair morphology 1 | 18
abnormal cornea morphology 1 | 24
abnormal gait 1 | 51
abnormal optic disc morphology 1 | 10
abnormal respiratory quotient 1 | 9
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal rib morphology 1 | 28
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 63
abnormal startle reflex 1 | 14
cardiovascular system phenotyp... 1 | 35
cataract 1 | 26
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating creatini... 1 | 31
decreased circulating iron lev... 1 | 25
decreased circulating magnesiu... 1 | 11
decreased circulating potassiu... 1 | 17
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased prepulse inhibition 1 | 52
decreased total retina thickne... 1 | 20
dilated heart left ventricle 1 | 10
female infertility 1 | 34
hydrops fetalis 1 | 22
impaired glucose tolerance 1 | 52
increased bone mineral density 1 | 52
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating free fat... 1 | 17
increased circulating glucose ... 1 | 16
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased heart weight 1 | 37
increased hematocrit 1 | 36
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased respiratory quotient 1 | 12
increased sacral vertebrae num... 1 | 62
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
oligodactyly 1 | 14
persistence of hyaloid vascula... 1 | 22
polycystic kidney 1 | 9
short tibia 1 | 82
small adrenal glands 1 | 15
small testis 1 | 37
thrombocytosis 1 | 23
vertebral fusion 1 | 23

Disease

Cancer 96 | 2,346
ovarian cancer 96 | 8,484
osteosarcoma 92 | 7,933
glioblastoma 84 | 5,572
psoriasis 80 | 6,685
medulloblastoma, large-cell 74 | 6,234
lung cancer 70 | 4,466
atypical teratoid / rhabdoid tumor 58 | 4,369
pilocytic astrocytoma 54 | 3,086
malignant mesothelioma 53 | 3,162
Breast cancer 47 | 3,094
oligodendroglioma 44 | 2,849
pediatric high grade glioma 44 | 2,712
subependymal giant cell astrocytoma 44 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 43 | 3,289
lung carcinoma 40 | 2,844
ulcerative colitis 40 | 2,087
ependymoma 39 | 2,514
primitive neuroectodermal tumor 39 | 3,031
diabetes mellitus 37 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,988
non-small cell lung cancer 33 | 2,798
pancreatic cancer 33 | 2,300
invasive ductal carcinoma 32 | 2,950
Carcinoma 31 | 2,147
lung adenocarcinoma 31 | 2,713
group 4 medulloblastoma 30 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,956
Rheumatoid Arthritis 29 | 1,160
astrocytic glioma 29 | 2,241
astrocytoma 29 | 1,493
interstitial cystitis 29 | 2,299
Pick disease 28 | 1,893
Vascular disease 28 | 281
tuberculosis 27 | 1,557
cystic fibrosis 26 | 1,665
adrenocortical carcinoma 25 | 1,427
medulloblastoma 25 | 1,524
adult high grade glioma 23 | 2,148
pituitary cancer 23 | 1,972
posterior fossa group A ependymoma 23 | 1,511
Lung Neoplasms 22 | 171
Parkinson's disease 22 | 364
juvenile dermatomyositis 22 | 1,189
Mammary Neoplasms 21 | 410
group 3 medulloblastoma 21 | 2,254
Alzheimer's disease 20 | 644
Toxic encephalopathy 20 | 131
primary pancreatic ductal adenocarcinoma 20 | 1,271
Arthritis 19 | 248
Endometriosis 19 | 535
Multiple myeloma 19 | 1,327
acute quadriplegic myopathy 19 | 1,157
ductal carcinoma in situ 19 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,795
Intellectual disability 18 | 573
colon cancer 18 | 1,475
dermatomyositis 18 | 933
Obesity 17 | 616
Schizophrenia 17 | 501
cutaneous lupus erythematosus 17 | 1,056
Kidney disease 16 | 396
Stomach Neoplasms 16 | 282
Liver carcinoma 15 | 217
Prostatic Neoplasms 15 | 471
acute myeloid leukemia 15 | 780
Amyotrophic Lateral Sclerosis 14 | 431
Brain Ischemia 14 | 87
Renal Cell Carcinoma 14 | 199
Waldenstrons macroglobulinemia 14 | 765
active Crohn's disease 14 | 918
gastric carcinoma 14 | 832
sonic hedgehog group medulloblastoma 14 | 1,482
Melanoma 13 | 261
Neoplasm Metastasis 13 | 138
Neurodegenerative disease 13 | 383
breast carcinoma 13 | 1,614
gastric cancer 13 | 430
Asthma 12 | 349
Lung disease 12 | 132
Myocardial Ischemia 12 | 169
Osteoporosis 12 | 257
Reperfusion Injury 12 | 84
atypical teratoid/rhabdoid tumor 12 | 1,095
esophageal adenocarcinoma 12 | 737
non primary Sjogren syndrome sicca 12 | 840
non-small cell lung carcinoma 12 | 413
pancreatic carcinoma 12 | 567
posterior fossa group B ependymoma 12 | 1,530
Chronic Lymphocytic Leukemia 11 | 242
Colonic Neoplasms 11 | 126
Colorectal Neoplasms 11 | 217
Diabetes Mellitus, Non-Insulin-Dependent 11 | 157
Eye disease 11 | 55
Heart disease 11 | 279
Status Epilepticus 11 | 85
hepatocellular carcinoma 11 | 532
inflammatory breast cancer 11 | 404
nasopharyngeal carcinoma 11 | 1,056
spina bifida 11 | 1,064

Tissue

Blood and immune system 167 | 17,995
Endocrine System 167 | 18,512
Female tissues 167 | 18,647
Liver and Pancreas 167 | 18,136
Nervous System 167 | 18,561
Urinary Tract 167 | 18,444
Cardiovascular System 166 | 17,958
Digestive Tract 166 | 18,473
Male tissues 166 | 17,969
Respiratory system 165 | 17,484
Skin and soft tissues 165 | 18,115

Target Family

Kinase 70 | 634
Non-IDG 44 | 11,971
Enzyme 37 | 4,146
Transcription Factor 14 | 1,400
Ion Channel 1 | 341
Nuclear Receptor 1 | 48

WikiPathways Pathway

MAPK Signaling Pathway 167 | 167
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
C-Jun-amino-terminal kinase-interacting protein 3 MAPK8IP3 Tbio Enzyme -1.63360 51.0 128
Interleukin-1 receptor type 2 IL1R2 Tbio Non-IDG -1.85724 72.1 361
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416
Tumor necrosis factor receptor superfamily member 6 FAS Tbio Non-IDG -3.27492 2052.7 1794
Interleukin-1 receptor type 1 IL1R1 Tclin Non-IDG -2.63413 362.9 482
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 Tbio Enzyme -1.83055 69.0 145