Development Level

Tchem 37 | 1,598
Tbio 22 | 11,445
Tclin 17 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal behavior 4 | 298
decreased body weight 4 | 161
abnormal gait 3 | 69
decreased total body fat amoun... 3 | 207
increased circulating alkaline... 3 | 122
increased neutrophil cell numb... 3 | 46
increased total body fat amoun... 3 | 134
preweaning lethality, incomple... 3 | 499
abnormal retina morphology 2 | 71
decreased bone mineral density 2 | 126
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased fasted circulating g... 2 | 65
decreased hematocrit 2 | 46
decreased lean body mass 2 | 135
decreased spleen weight 2 | 10
impaired righting response 2 | 26
increased lean body mass 2 | 172
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
tremors 2 | 39
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal digit morphology 1 | 10
abnormal eye size 1 | 7
abnormal femur morphology 1 | 14
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal skin condition 1 | 6
absent vibrissae 1 | 12
cataract 1 | 92
decreased IgG3 level 1 | 1
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating glycerol... 1 | 16
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased monocyte cell number 1 | 8
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
enlarged liver 1 | 2
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hyperactivity 1 | 148
hypoactivity 1 | 132
increased IgM level 1 | 1
increased T cell number 1 | 6
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
limb grasping 1 | 41
short tibia 1 | 97
small seminal vesicle 1 | 10
thrombocytopenia 1 | 56
trunk curl 1 | 16

Disease

Cancer 60 | 2,499
Carcinoma 60 | 11,493
ovarian cancer 52 | 8,520
osteosarcoma 48 | 7,950
lung cancer 38 | 4,740
glioblastoma 35 | 5,792
psoriasis 35 | 6,694
medulloblastoma, large-cell 33 | 6,241
atypical teratoid / rhabdoid tumor 31 | 5,112
Kidney cancer 30 | 2,613
ependymoma 28 | 4,679
Breast cancer 27 | 3,578
diabetes mellitus 27 | 1,728
Obesity 24 | 678
adult high grade glioma 24 | 3,801
Schizophrenia 22 | 1,160
tuberculosis 21 | 2,010
Vascular disease 20 | 319
invasive ductal carcinoma 19 | 2,951
group 3 medulloblastoma 18 | 4,104
group 4 medulloblastoma 18 | 1,855
oligodendroglioma 18 | 2,850
Astrocytoma, Pilocytic 17 | 3,081
Breast Neoplasms 17 | 445
Mammary Neoplasms 17 | 425
Stomach Neoplasms 17 | 300
breast carcinoma 17 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
Alzheimer's disease 16 | 658
Hyperglycemia 16 | 137
Multiple myeloma 16 | 1,332
Prostatic Neoplasms 16 | 495
ductal carcinoma in situ 16 | 1,745
Arthritis 15 | 290
Hypertension 15 | 396
Rheumatoid arthritis 15 | 1,191
malignant mesothelioma 15 | 3,232
pancreatic cancer 15 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
Heart disease 14 | 306
interstitial cystitis 14 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
non-small cell lung cancer 14 | 2,890
Carcinoma, Hepatocellular 13 | 228
Liver carcinoma 13 | 240
Lung Neoplasms 13 | 232
Neoplasm Invasiveness 13 | 161
astrocytoma 13 | 1,146
lung adenocarcinoma 13 | 2,716
subependymal giant cell astrocytoma 13 | 2,287
Asthma 12 | 385
Autosomal recessive predisposition 12 | 1,442
Bipolar Disorder 12 | 666
Cell Transformation, Neoplastic 12 | 97
Depressive disorder 12 | 409
Short stature 12 | 531
lung carcinoma 12 | 2,843
pituitary cancer 12 | 1,972
primitive neuroectodermal tumor 12 | 3,035
Neoplastic Cell Transformation 11 | 89
Pick disease 11 | 1,894
astrocytic glioma 11 | 2,597
cystic fibrosis 11 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
juvenile dermatomyositis 11 | 1,187
ulcerative colitis 11 | 1,819
Adenocarcinoma 10 | 122
Brain Ischemia 10 | 110
Byzanthine arch palate 10 | 194
Colonic Neoplasms 10 | 142
Hypertensive disease 10 | 292
Insulin Resistance 10 | 72
Intellectual disability 10 | 1,016
Kidney disease 10 | 430
Mental Depression 10 | 333
Neoplasm Metastasis 10 | 168
Orbital separation excessive 10 | 244
Renal Cell Carcinoma 10 | 214
spina bifida 10 | 1,074
Acquired scoliosis 9 | 281
Cognitive delay 9 | 608
Curvature of spine 9 | 282
Disease Models, Animal 9 | 155
Epilepsy 9 | 792
Global developmental delay 9 | 608
Hyperinsulinism 9 | 133
Lung disease 9 | 142
Mammary Neoplasms, Experimental 9 | 154
Mental and motor retardation 9 | 608
Muscle hypotonia 9 | 571
Myocardial Infarction 9 | 151
Parkinson's disease 9 | 392
Seizures 9 | 596
Squamous cell carcinoma 9 | 129
primary pancreatic ductal adenocarcinoma 9 | 1,109
Diabetes Mellitus, Non-Insulin-Dependent 8 | 145
Diabetes Mellitus, Type 2 8 | 142
acute quadriplegic myopathy 8 | 1,158
colon cancer 8 | 1,478
dermatomyositis 8 | 966

Tissue

Blood and immune system 76 | 16,909
Cardiovascular System 76 | 15,192
Digestive Tract 76 | 17,369
Endocrine System 76 | 18,159
Female tissues 76 | 17,400
Liver and Pancreas 76 | 16,750
Male tissues 76 | 17,142
Nervous System 76 | 16,725
Respiratory system 76 | 16,393
Skin and soft tissues 76 | 17,230
Urinary Tract 76 | 16,678

Target Family

Kinase 27 | 634
Non-IDG 23 | 12,091
Enzyme 14 | 4,145
Transcription Factor 10 | 1,400
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

WikiPathways Pathway

Leptin signaling pathway 76 | 76
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
Leptin receptor LEPR Tclin Non-IDG -3.01833 782.6 615
Suppressor of cytokine signaling 7 SOCS7 Tbio Non-IDG -1.64336 42.5 122
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Focal adhesion kinase 1 PTK2 Tchem Kinase -3.06733 1038.3 2013
Acetyl-CoA carboxylase 2 ACACB Tchem Enzyme -2.25387 171.9 125