Development Level

Tbio 10 | 11,445
Tchem 4 | 1,598
Tclin 3 | 613

IMPC Phenotype

abnormal behavior 1 | 298
abnormal gait 1 | 69
abnormal locomotor behavior 1 | 24
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating chloride... 1 | 30
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased spleen weight 1 | 10
enlarged liver 1 | 2
hypoactivity 1 | 132
impaired righting response 1 | 26
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
preweaning lethality, complete... 1 | 979
small seminal vesicle 1 | 10
thrombocytopenia 1 | 56
tremors 1 | 39
trunk curl 1 | 16

Disease

Cancer 15 | 2,499
Carcinoma 12 | 11,493
ovarian cancer 12 | 8,520
Obesity 10 | 678
diabetes mellitus 10 | 1,728
osteosarcoma 10 | 7,950
psoriasis 10 | 6,694
Breast cancer 9 | 3,578
atypical teratoid / rhabdoid tumor 9 | 5,112
lung cancer 9 | 4,740
Hyperglycemia 8 | 137
invasive ductal carcinoma 8 | 2,951
Hyperinsulinism 7 | 133
adult high grade glioma 7 | 3,801
medulloblastoma, large-cell 7 | 6,241
Arthritis 6 | 290
Astrocytoma, Pilocytic 6 | 3,081
Atopic dermatitis 6 | 952
Diabetes Mellitus, Non-Insulin-Dependent 6 | 145
Fatty liver disease 6 | 103
Insulin Resistance 6 | 72
Kidney cancer 6 | 2,613
Liver disease 6 | 237
Prostatic Neoplasms 6 | 495
breast carcinoma 6 | 1,638
ependymoma 6 | 4,679
glioblastoma 6 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
Alzheimer's disease 5 | 658
Breast Neoplasms 5 | 445
Diabetes Mellitus, Experimental 5 | 108
Diabetes Mellitus, Type 2 5 | 142
Liver Cirrhosis, Experimental 5 | 769
Mammary Neoplasms 5 | 425
Polycystic ovary syndrome 5 | 360
cystic fibrosis 5 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
malignant mesothelioma 5 | 3,232
tuberculosis 5 | 2,010
Anemia 4 | 365
Asthma 4 | 385
Atherosclerosis 4 | 291
Fibrosis 4 | 44
Glucose Intolerance 4 | 19
Gynecomastia 4 | 64
Heart disease 4 | 306
Hypertension 4 | 396
Hypertensive disease 4 | 292
Hypothyroidism 4 | 122
Inflammation 4 | 120
Kidney disease 4 | 430
Lipid metabolism disorder 4 | 114
Rheumatoid arthritis 4 | 1,191
Schizophrenia 4 | 1,160
Vascular disease 4 | 319
active ulcerative colitis 4 | 764
ductal carcinoma in situ 4 | 1,745
lung adenocarcinoma 4 | 2,716
lung carcinoma 4 | 2,843
non-small cell lung cancer 4 | 2,890
pituitary cancer 4 | 1,972
primary Sjogren syndrome 4 | 735
ulcerative colitis 4 | 1,819
Advanced bone age 3 | 35
Alzheimer Disease 3 | 83
Bipolar Disorder 3 | 666
Byzanthine arch palate 3 | 194
Carcinoma, Hepatocellular 3 | 228
Cardiomegaly 3 | 116
Cognitive delay 3 | 608
Coronary artery disease 3 | 268
Depressive disorder 3 | 409
Fatty Liver 3 | 70
Global developmental delay 3 | 608
Heart failure 3 | 162
Hepatitis C 3 | 94
Hyperandrogenism 3 | 34
Hypersensitivity reaction type II disease 3 | 253
Hypoglycemia 3 | 152
Hypogonadism 3 | 173
Impaired glucose tolerance 3 | 28
Infertility 3 | 188
Inflammatory bowel disease 3 | 151
Liver carcinoma 3 | 240
Mental and motor retardation 3 | 608
Osteoporosis 3 | 363
Seizures 3 | 596
Stomach Neoplasms 3 | 300
Weight decreased 3 | 103
adrenocortical carcinoma 3 | 1,428
cutaneous lupus erythematosus 3 | 1,057
group 3 medulloblastoma 3 | 4,104
interstitial cystitis 3 | 2,312
medulloblastoma 3 | 720
pancreatic cancer 3 | 2,398
pancreatic carcinoma 3 | 562
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
primitive neuroectodermal tumor 3 | 3,035
subependymal giant cell astrocytoma 3 | 2,287

Tissue

Digestive Tract 17 | 17,369
Endocrine System 17 | 18,159
Female tissues 17 | 17,400
Nervous System 17 | 16,725
Skin and soft tissues 17 | 17,230
Blood and immune system 16 | 16,909
Cardiovascular System 16 | 15,192
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Respiratory system 16 | 16,393
Urinary Tract 16 | 16,678

Target Family

Non-IDG 9 | 12,091
Kinase 5 | 634
Enzyme 2 | 4,145
Transcription Factor 1 | 1,400

WikiPathways Pathway

Leptin Insulin Overlap 17 | 17
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Leptin receptor LEPR Tclin Non-IDG -3.01833 782.6 615
Insulin receptor substrate 4 IRS4 Tbio Non-IDG -1.60429 0.00000 121
Insulin receptor INSR Tclin Kinase -2.50045 306.8 1417
Insulin receptor substrate 2 IRS2 Tbio Non-IDG -2.64133 414.7 227
Diacylglycerol kinase zeta DGKZ Tbio Enzyme -1.89662 90.6 157
3-phosphoinositide-dependent protein kinase 1 PDPK1 Tchem Kinase -2.12025 204.9 608
Suppressor of cytokine signaling 1 SOCS1 Tbio Non-IDG -3.05851 1163.8 469
Suppressor of cytokine signaling 3 SOCS3 Tbio Non-IDG -3.05657 1157.2 518
Suppressor of cytokine signaling 2 SOCS2 Tbio Non-IDG -2.90841 804.7 196
Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 Tbio Enzyme -1.57214 38.2 155