Development Level

Tchem 26 | 1,598
Tbio 23 | 11,445
Tclin 10 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal gait 3 | 69
decreased body weight 3 | 161
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
decreased total body fat amoun... 2 | 207
increased neutrophil cell numb... 2 | 46
thrombocytopenia 2 | 56
abnormal cornea morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
cataract 1 | 92
decreased bone mineral density 1 | 126
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hypoactivity 1 | 132
impaired righting response 1 | 26
increased CD4-positive, alpha ... 1 | 4
increased blood urea nitrogen ... 1 | 48
increased heart left ventricle... 1 | 4
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
polycystic kidney 1 | 15
small spleen 1 | 19

Disease

Carcinoma 49 | 11,493
Cancer 47 | 2,499
osteosarcoma 40 | 7,950
ovarian cancer 40 | 8,520
psoriasis 28 | 6,694
glioblastoma 27 | 5,792
lung cancer 27 | 4,740
medulloblastoma, large-cell 26 | 6,241
atypical teratoid / rhabdoid tumor 20 | 5,112
Breast cancer 19 | 3,578
group 4 medulloblastoma 19 | 1,855
Kidney cancer 17 | 2,613
ependymoma 16 | 4,679
invasive ductal carcinoma 15 | 2,951
tuberculosis 15 | 2,010
Breast Neoplasms 14 | 445
Mammary Neoplasms 14 | 425
Schizophrenia 14 | 1,160
Short stature 14 | 531
adult high grade glioma 14 | 3,801
group 3 medulloblastoma 14 | 4,104
lung carcinoma 14 | 2,843
subependymal giant cell astrocytoma 14 | 2,287
Stomach Neoplasms 13 | 300
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
malignant mesothelioma 13 | 3,232
non-small cell lung cancer 13 | 2,890
Arthritis 12 | 290
Vascular disease 12 | 319
Alzheimer's disease 11 | 658
Astrocytoma, Pilocytic 11 | 3,081
Heart disease 11 | 306
Lung Neoplasms 11 | 232
Orbital separation excessive 11 | 244
astrocytoma 11 | 1,146
diabetes mellitus 11 | 1,728
Blepharoptosis 10 | 231
Byzanthine arch palate 10 | 194
Cognitive delay 10 | 608
Downward slant of palpebral fissure 10 | 158
Frontal bossing 10 | 157
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
Multiple myeloma 10 | 1,332
Rheumatoid arthritis 10 | 1,191
astrocytic glioma 10 | 2,597
ductal carcinoma in situ 10 | 1,745
interstitial cystitis 10 | 2,312
lung adenocarcinoma 10 | 2,716
ulcerative colitis 10 | 1,819
Acquired scoliosis 9 | 281
Bipolar Disorder 9 | 666
Concave bridge of nose 9 | 195
Congenital Epicanthus 9 | 177
Cryptorchidism 9 | 296
Curvature of spine 9 | 282
Delayed bone age 9 | 136
Depressed nasal bridge 9 | 195
Depressed nasal root/bridge 9 | 195
Dull intelligence 9 | 645
Intellectual disability 9 | 1,016
Low intelligence 9 | 645
Melanoma 9 | 711
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Muscle hypotonia 9 | 571
Obesity 9 | 678
Pectus excavatum 9 | 100
Pick disease 9 | 1,894
Poor school performance 9 | 645
juvenile dermatomyositis 9 | 1,187
oligodendroglioma 9 | 2,850
pancreatic cancer 9 | 2,398
pituitary cancer 9 | 1,972
primary Sjogren syndrome 9 | 735
primitive neuroectodermal tumor 9 | 3,035
Anemia 8 | 365
Hypoplastic mandible condyle 8 | 275
Kidney disease 8 | 430
Mandibular hypoplasia 8 | 275
Micrognathism 8 | 275
Multiple Sclerosis 8 | 540
Neoplasm Invasiveness 8 | 161
Neoplasm Metastasis 8 | 168
Renal Cell Carcinoma 8 | 214
Sensorineural Hearing Loss (disorder) 8 | 284
Small head 8 | 374
Strabismus 8 | 270
Waldenstrons macroglobulinemia 8 | 765
cutaneous lupus erythematosus 8 | 1,057
cystic fibrosis 8 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Asthma 7 | 385
Depressive disorder 7 | 409
Feeding difficulties in infancy 7 | 175
Immune system cancer 7 | 140
Prostatic Neoplasms 7 | 495
Short neck 7 | 140
dermatomyositis 7 | 966

Tissue

Blood and immune system 58 | 16,909
Cardiovascular System 58 | 15,192
Digestive Tract 58 | 17,369
Endocrine System 58 | 18,159
Female tissues 58 | 17,400
Liver and Pancreas 58 | 16,750
Male tissues 58 | 17,142
Nervous System 58 | 16,725
Respiratory system 58 | 16,393
Skin and soft tissues 58 | 17,230
Urinary Tract 58 | 16,678

Target Family

Kinase 22 | 634
Non-IDG 18 | 12,091
Transcription Factor 11 | 1,400
Enzyme 7 | 4,145
Epigenetic 1 | 242

WikiPathways Pathway

Kit receptor signaling pathway 59 | 59
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Zinc finger protein SNAI2 SNAI2 Tbio Transcription Factor -3.25853 1689.4 685
Megakaryocyte-associated tyrosine-protein kinase MATK Tbio Kinase -2.98596 792.3 265
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
Ribosomal protein S6 kinase alpha-3 RPS6KA3 Tchem Kinase -2.50143 325.4 425
40S ribosomal protein S6 RPS6 Tbio Non-IDG -2.76789 501.6 920
GRB2-associated-binding protein 2 GAB2 Tbio Non-IDG -2.08460 139.8 494
Ribosomal protein S6 kinase beta-1 RPS6KB1 Tchem Kinase -3.18361 0.00000 1818