Development Level

Tbio 9 | 11,445
Tchem 3 | 1,598

IMPC Phenotype

embryonic lethality prior to t... 2 | 278
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
decreased bone mineral content 1 | 151
decreased erythrocyte cell num... 1 | 62
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
hyperactivity 1 | 148
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased mean corpuscular hem... 1 | 96
long tibia 1 | 25
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Anemia 9 | 365
Carcinoma 9 | 11,493
medulloblastoma, large-cell 8 | 6,241
Hemochromatosis 7 | 54
ovarian cancer 7 | 8,520
atypical teratoid / rhabdoid tumor 6 | 5,112
glioblastoma 6 | 5,792
osteosarcoma 6 | 7,950
psoriasis 6 | 6,694
Aceruloplasminemia 5 | 16
Breast cancer 5 | 3,578
Atransferrinemia 4 | 8
Cancer 4 | 2,499
Hyperferritinaemia 4 | 14
Increased ferritin 4 | 14
Iron Overload 4 | 5
Liver disease 4 | 237
Neoplasm Invasiveness 4 | 161
Serum ferritin increased 4 | 14
Thalassemia 4 | 53
ependymoma 4 | 4,679
invasive ductal carcinoma 4 | 2,951
malignant mesothelioma 4 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
primitive neuroectodermal tumor 4 | 3,035
Astrocytoma, Pilocytic 3 | 3,081
Autosomal recessive predisposition 3 | 1,442
Beta thalassemia 3 | 16
Hemoglobin low 3 | 124
Iron deficiency anemia 3 | 12
Kidney disease 3 | 430
Malaria 3 | 160
Obesity 3 | 678
Parkinson's disease 3 | 392
Pick disease 3 | 1,894
aldosterone-producing adenoma 3 | 665
beta-Thalassemia 3 | 10
cystic fibrosis 3 | 1,696
ductal carcinoma in situ 3 | 1,745
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung adenocarcinoma 3 | 2,716
lung cancer 3 | 4,740
lung carcinoma 3 | 2,843
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
pancreatic cancer 3 | 2,398
pituitary cancer 3 | 1,972
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 2,010
Abnormality of the liver 2 | 21
Alcoholic Intoxication, Chronic 2 | 289
Alzheimer's disease 2 | 658
Anemia, Hypochromic Microcytic, With Iron Overload 2 | 2
Anemia, Iron-Deficiency 2 | 4
Autistic Disorder 2 | 364
Cell Transformation, Neoplastic 2 | 97
Diarrhea 2 | 253
Duchenne muscular dystrophy 2 | 601
Fatty liver disease 2 | 103
Glioma 2 | 74
Hemochromatosis type 1 2 | 9
Hepatitis C 2 | 94
Inflammation 2 | 120
Iron metabolism disease 2 | 20
Kidney cancer 2 | 2,613
Liver diseases 2 | 87
Liver neoplasms 2 | 130
Mesothelioma, Malignant 2 | 105
Multiple myeloma 2 | 1,332
Neoplastic Cell Transformation 2 | 89
Neurodegenerative disease 2 | 414
Peripheral vascular disease 2 | 87
Porphyria cutanea tarda 2 | 12
Siderosis 2 | 9
Waldenstrons macroglobulinemia 2 | 765
acute myeloid leukemia 2 | 783
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
astrocytic glioma 2 | 2,597
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
esophageal adenocarcinoma 2 | 737
group 4 medulloblastoma 2 | 1,855
hepatocellular carcinoma 2 | 547
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
non diabetic and post-ischemic heart failure 2 | 200
nutritional deficiency disease 2 | 9
pediatric high grade glioma 2 | 1,064
progressive supranuclear palsy 2 | 676
substance-related disorder 2 | 162
type II diabetes mellitus and post-ischemic heart failure 2 | 88
ulcerative colitis 2 | 1,819
Abdominal Pain 1 | 98
Animal Mammary Neoplasms 1 | 136
Arthralgia 1 | 90
Breast Neoplasms 1 | 445
Leukemia, Lymphocytic, Chronic, B-Cell 1 | 34
Mammary Neoplasms, Experimental 1 | 154

Tissue

Blood and immune system 12 | 16,909
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 11 | 16,750
Nervous System 11 | 16,725
Skin and soft tissues 11 | 17,230
Cardiovascular System 10 | 15,192
Male tissues 10 | 17,142
Respiratory system 10 | 16,393
Urinary Tract 10 | 16,678

Target Family

Non-IDG 6 | 12,091
Enzyme 3 | 4,145
Transporter 2 | 473
Ion Channel 1 | 344

WikiPathways Pathway

Iron metabolism in placenta 12 | 12
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serotransferrin TF Tbio Non-IDG -4.15070 13447.9 1168
Iron-responsive element-binding protein 2 IREB2 Tbio Non-IDG -2.33609 211.7 253
Transferrin receptor protein 1 TFRC Tbio Non-IDG -3.43851 2558.3 1677
Natural resistance-associated macrophage protein 2 SLC11A2 Tchem Transporter -2.53965 373.5 250
Cytoplasmic aconitate hydratase ACO1 Tbio Enzyme -2.59601 396.5 350
Mucolipin-1 MCOLN1 Tchem Ion Channel -2.43459 272.2 132
Hephaestin-like protein 1 HEPHL1 Tbio Non-IDG 0.19 0.54 56
Hepcidin HAMP Tbio Non-IDG -3.30891 2214.4 306
Transferrin receptor protein 2 TFR2 Tbio Enzyme -2.11882 135.2 149
Ferritin heavy chain FTH1 Tbio Non-IDG -3.00480 982.1 562