Development Level

Tchem 7 | 1,598
Tbio 3 | 11,445
Tclin 3 | 613

IMPC Phenotype

abnormal sleep behavior 1 | 70
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
hypoactivity 1 | 132
increased circulating HDL chol... 1 | 80
increased circulating bilirubi... 1 | 16
increased kidney weight 1 | 6
increased total body fat amoun... 1 | 134
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 13 | 11,493
Cancer 9 | 2,499
psoriasis 8 | 6,694
Adverse reaction to drug 7 | 61
Drug-Related Side Effects and Adverse Reactions 7 | 62
lung cancer 6 | 4,740
medulloblastoma, large-cell 6 | 6,241
osteosarcoma 6 | 7,950
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Breast Neoplasms 5 | 445
Kidney cancer 5 | 2,613
Mammary Neoplasms 5 | 425
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
lung carcinoma 5 | 2,843
ovarian cancer 5 | 8,520
Autosomal recessive predisposition 4 | 1,442
Bilirubin metabolic disorder 4 | 41
Chemical and Drug Induced Liver Injury 4 | 195
Liver disease 4 | 237
cutaneous lupus erythematosus 4 | 1,057
lung adenocarcinoma 4 | 2,716
non-small cell lung cancer 4 | 2,890
Carcinoma, squamous cell of head and neck 3 | 31
Cholestasis 3 | 155
Cocaine-Related Disorders 3 | 92
Colorectal Neoplasms 3 | 243
Diarrhea 3 | 253
Epilepsy 3 | 792
Hypertension 3 | 396
Icterus 3 | 82
Neonatal Jaundice 3 | 30
Neutropenia 3 | 72
Obesity 3 | 678
Rheumatoid arthritis 3 | 1,191
Seizures 3 | 596
Sickle Cell Anemia 3 | 53
Squamous cell carcinoma of the head and neck 3 | 29
active Crohn's disease 3 | 922
ependymoma 3 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
malignant mesothelioma 3 | 3,232
Acute kidney injury 2 | 70
Anemia 2 | 365
Arthritis, Rheumatoid 2 | 174
Astrocytoma, Pilocytic 2 | 3,081
Attention deficit hyperactivity disorder 2 | 278
BILIARY TRACT ABNORMALITY 2 | 16
Biliary Tract Diseases 2 | 16
Biliary cirrhosis 2 | 45
Conjugated hyperbilirubinemia 2 | 14
Dementia 2 | 175
Echinococcosis 2 | 26
Gout 2 | 106
Heart Diseases 2 | 43
Human immunodeficiency virus infection 2 | 6
Hyperbilirubinemia 2 | 4
Hyperuricemia 2 | 49
Kernicterus 2 | 11
Liver Cirrhosis 2 | 181
Liver Cirrhosis, Biliary 2 | 33
Liver Cirrhosis, Experimental 2 | 769
Liver cancer 2 | 604
Myopathy 2 | 185
Nervous System Diseases 2 | 53
Neurotoxicity Syndromes 2 | 26
Pericholangitis 2 | 8
Prolonged neonatal jaundice 2 | 17
Prostatic Neoplasms 2 | 495
Schizophrenia 2 | 1,160
Toxic encephalopathy 2 | 141
adrenocortical adenoma 2 | 131
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
astrocytic glioma 2 | 2,597
atypical teratoid / rhabdoid tumor 2 | 5,112
colon cancer 2 | 1,478
drug-induced hepatitis 2 | 44
glioblastoma 2 | 5,792
interstitial cystitis 2 | 2,312
medulloblastoma 2 | 720
nervous system disorder 2 | 53
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
tuberculosis 2 | 2,010
ulcerative colitis 2 | 1,819
Abnormal pigmentation 1 | 25
Chronic schizophrenia 1 | 16
Drug allergy 1 | 36
HYPERBILIRUBINEMIA, ROTOR TYPE 1 | 2
Human immunodeficiency virus infectious disease 1 | 138
Hypertriglyceridemia 1 | 17
Keratoconjunctivitis sicca 1 | 25
Muscular Dystrophies 1 | 8
Prevention of Cardiac Transplant Rejection 1 | 15
Prevention of Kidney Transplant Rejection 1 | 17
Prevention of Liver Transplant Rejection 1 | 15
Rotor Syndrome 1 | 2
Severe Recalcitrant Psoriasis 1 | 12
Tear film insufficiency 1 | 15

Tissue

Liver and Pancreas 13 | 16,750
Urinary Tract 13 | 16,678
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Male tissues 12 | 17,142
Skin and soft tissues 12 | 17,230
Blood and immune system 11 | 16,909
Nervous System 10 | 16,725
Respiratory system 9 | 16,393
Cardiovascular System 7 | 15,192

Target Family

Enzyme 8 | 4,145
Transporter 4 | 473
Non-IDG 1 | 12,091

WikiPathways Pathway

Irinotecan Pathway 13 | 13
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Niemann-Pick C1 protein NPC1 Tbio Non-IDG -2.71962 551.3 284
Multidrug resistance-associated protein 1 ABCC1 Tchem Transporter -2.81072 662.2 328
UDP-glucuronosyltransferase 1-1 UGT1A1 Tchem Enzyme -2.95436 932.5 146
Canalicular multispecific organic anion transporter 1 ABCC2 Tchem Transporter -2.90204 834.9 234
Cytochrome P450 3A4 CYP3A4 Tclin Enzyme -3.65839 4688.0 397
Solute carrier organic anion transporter family member 1B1 SLCO1B1 Tchem Transporter -2.77788 574.0 124
Liver carboxylesterase 1 CES1 Tchem Enzyme -2.62475 722.3 209
UDP-glucuronosyltransferase 1-10 UGT1A10 Tbio Enzyme -1.69563 49.3 17
ATP-binding cassette sub-family G member 2 ABCG2 Tchem Transporter -3.41877 2731.1 246
Cocaine esterase CES2 Tchem Enzyme -2.43360 271.1 276