Development Level

Tbio 54 | 11,445
Tchem 30 | 1,598
Tclin 15 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 3 | 125
RFA-RM-18-021 3 | 328

IMPC Phenotype

preweaning lethality, complete... 9 | 979
decreased body weight 3 | 161
increased circulating triglyce... 3 | 42
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal retina morphology 2 | 71
decreased neutrophil cell numb... 2 | 42
embryonic lethality prior to o... 2 | 239
increased circulating alkaline... 2 | 122
increased hematocrit 2 | 46
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal lens morphology 1 | 81
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
hemorrhage 1 | 23
hyperactivity 1 | 148
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased caudal vertebrae num... 1 | 7
increased circulating LDL chol... 1 | 13
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
short tibia 1 | 97
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
tremors 1 | 39
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 85 | 11,493
osteosarcoma 59 | 7,950
Cancer 57 | 2,499
ovarian cancer 54 | 8,520
glioblastoma 50 | 5,792
psoriasis 38 | 6,694
lung cancer 35 | 4,740
medulloblastoma, large-cell 35 | 6,241
atypical teratoid / rhabdoid tumor 33 | 5,112
Kidney cancer 29 | 2,613
ependymoma 29 | 4,679
Breast cancer 28 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
invasive ductal carcinoma 27 | 2,951
Astrocytoma, Pilocytic 26 | 3,081
adult high grade glioma 26 | 3,801
malignant mesothelioma 26 | 3,232
group 3 medulloblastoma 25 | 4,104
lung carcinoma 25 | 2,843
non-small cell lung cancer 25 | 2,890
pancreatic cancer 25 | 2,398
tuberculosis 24 | 2,010
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,989
diabetes mellitus 20 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,955
astrocytic glioma 18 | 2,597
cystic fibrosis 18 | 1,696
interstitial cystitis 18 | 2,312
oligodendroglioma 18 | 2,850
colon cancer 17 | 1,478
lung adenocarcinoma 17 | 2,716
Intellectual disability 16 | 1,016
subependymal giant cell astrocytoma 16 | 2,287
Autosomal recessive predisposition 15 | 1,442
group 4 medulloblastoma 15 | 1,855
ulcerative colitis 15 | 1,819
primitive neuroectodermal tumor 14 | 3,035
Dull intelligence 13 | 645
Low intelligence 13 | 645
Mental Retardation 13 | 645
Mental deficiency 13 | 645
Poor school performance 13 | 645
primary pancreatic ductal adenocarcinoma 13 | 1,109
Liver Cirrhosis, Experimental 12 | 769
Schizophrenia 12 | 1,160
breast carcinoma 12 | 1,638
juvenile dermatomyositis 12 | 1,187
Epilepsy 11 | 792
Multiple myeloma 11 | 1,332
Orbital separation excessive 11 | 244
Short stature 11 | 531
astrocytoma 11 | 1,146
ductal carcinoma in situ 11 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Blepharoptosis 10 | 231
Byzanthine arch palate 10 | 194
Duchenne muscular dystrophy 10 | 601
Muscle hypotonia 10 | 571
pediatric high grade glioma 10 | 1,064
pituitary cancer 10 | 1,972
Acquired scoliosis 9 | 281
Breast Neoplasms 9 | 445
Concave bridge of nose 9 | 195
Curvature of spine 9 | 282
Depressed nasal bridge 9 | 195
Depressed nasal root/bridge 9 | 195
Hypertrophic Cardiomyopathy 9 | 117
Mammary Neoplasms 9 | 425
Melanoma 9 | 711
Pick disease 9 | 1,894
Prostatic Neoplasms 9 | 495
Seizures 9 | 596
Vascular disease 9 | 319
dermatomyositis 9 | 966
Arthritis 8 | 290
Big calvaria 8 | 147
Cardiomyopathy 8 | 116
Cognitive delay 8 | 608
Gliosis 8 | 56
Global developmental delay 8 | 608
Heart disease 8 | 306
Increased head circumference 8 | 147
Increased size of cranium 8 | 147
Increased size of skull 8 | 147
Large auricle 8 | 87
Large dysplastic ears 8 | 87
Large pinnae 8 | 87
Large prominent ears 8 | 87
Large protruding ears 8 | 87
Large, floppy ears 8 | 87
Macrotia 8 | 87
Mental and motor retardation 8 | 608
Neoplasm Invasiveness 8 | 161
Stomach Neoplasms 8 | 300
Strabismus 8 | 270
Bipolar Disorder 7 | 666
Endometriosis 7 | 540
Rheumatoid arthritis 7 | 1,191
adrenocortical carcinoma 7 | 1,428
cutaneous lupus erythematosus 7 | 1,057

Tissue

Blood and immune system 99 | 16,909
Digestive Tract 99 | 17,369
Endocrine System 99 | 18,159
Female tissues 99 | 17,400
Liver and Pancreas 99 | 16,750
Male tissues 99 | 17,142
Skin and soft tissues 99 | 17,230
Urinary Tract 98 | 16,678
Cardiovascular System 97 | 15,192
Nervous System 97 | 16,725
Respiratory system 97 | 16,393

Target Family

Non-IDG 59 | 12,091
Kinase 31 | 634
Enzyme 9 | 4,145
GPCR 1 | 408

WikiPathways Pathway

Integrin-mediated Cell Adhesio... 100 | 100
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Integrin alpha-7 ITGA7 Tbio Non-IDG -1.63563 42.4 193
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Tensin-1 TNS1 Tbio Non-IDG -2.74141 354.5 133
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Calpain-10 CAPN10 Tbio Non-IDG -2.27096 197.8 112
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Integrin alpha-8 ITGA8 Tbio Non-IDG -1.36974 22.0 145
Sorbin and SH3 domain-containing protein 1 SORBS1 Tbio Non-IDG -1.57341 40.2 224
Calpain-11 CAPN11 Tdark Non-IDG -0.74806 4.84 136