Development Level

Tchem 25 | 1,598
Tbio 17 | 11,445
Tclin 3 | 613

IMPC Phenotype

decreased mean corpuscular vol... 3 | 79
hyperactivity 3 | 148
preweaning lethality, incomple... 3 | 499
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased circulating sodium l... 2 | 71
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96
increased mean corpuscular hem... 2 | 36
preweaning lethality, complete... 2 | 979
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal spinal cord morpholog... 1 | 9
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
edema 1 | 59
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
female infertility 1 | 60
impaired righting response 1 | 26
increased bone mineral content 1 | 108
increased fasted circulating g... 1 | 76
increased lymphocyte cell numb... 1 | 32
increased neutrophil cell numb... 1 | 46
male infertility 1 | 123
microphthalmia 1 | 26
small seminal vesicle 1 | 10
small testis 1 | 58

Disease

Cancer 37 | 2,499
Carcinoma 34 | 11,493
ovarian cancer 34 | 8,520
glioblastoma 30 | 5,792
lung cancer 28 | 4,740
medulloblastoma, large-cell 28 | 6,241
Breast cancer 27 | 3,578
osteosarcoma 27 | 7,950
atypical teratoid / rhabdoid tumor 26 | 5,112
malignant mesothelioma 24 | 3,232
psoriasis 23 | 6,694
Kidney cancer 20 | 2,613
group 3 medulloblastoma 20 | 4,104
ependymoma 17 | 4,679
primitive neuroectodermal tumor 17 | 3,035
Breast Neoplasms 16 | 445
Mammary Neoplasms 16 | 425
non-small cell lung cancer 16 | 2,890
Prostatic Neoplasms 15 | 495
adult high grade glioma 15 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
breast carcinoma 13 | 1,638
Astrocytoma, Pilocytic 12 | 3,081
adrenocortical carcinoma 12 | 1,428
ductal carcinoma in situ 12 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
invasive ductal carcinoma 12 | 2,951
lung adenocarcinoma 12 | 2,716
nasopharyngeal carcinoma 12 | 1,058
Autosomal recessive predisposition 11 | 1,442
Lymphoma 11 | 81
Melanoma 11 | 711
Stomach Neoplasms 11 | 300
colon cancer 11 | 1,478
pancreatic cancer 11 | 2,398
Carcinoma, Hepatocellular 10 | 228
Liver carcinoma 10 | 240
Lung Neoplasms 10 | 232
Vascular disease 10 | 319
dermatomyositis 10 | 966
diabetes mellitus 10 | 1,728
oligodendroglioma 10 | 2,850
tuberculosis 10 | 2,010
Adenoma 9 | 167
Ataxia telangiectasia 9 | 34
Leukemia 9 | 104
subependymal giant cell astrocytoma 9 | 2,287
Asthma 8 | 385
Multiple myeloma 8 | 1,332
Nijmegen breakage syndrome 8 | 24
Pancreatic Neoplasm 8 | 85
Short stature 8 | 531
acute quadriplegic myopathy 8 | 1,158
juvenile dermatomyositis 8 | 1,187
ulcerative colitis 8 | 1,819
Colonic Neoplasms 7 | 142
Colorectal Neoplasms 7 | 243
Epilepsy 7 | 792
Hereditary Breast and Ovarian Cancer Syndrome 7 | 14
Schizophrenia 7 | 1,160
Seizures 7 | 596
astrocytic glioma 7 | 2,597
group 4 medulloblastoma 7 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
pituitary cancer 7 | 1,972
Alzheimer's disease 6 | 658
Amyotrophic lateral sclerosis 6 | 451
Carcinoma, Non-Small-Cell Lung 6 | 107
Cell Transformation, Neoplastic 6 | 97
Chronic Lymphocytic Leukemia 6 | 262
Glioma 6 | 74
Hypertension 6 | 396
Immune system cancer 6 | 140
Liver cancer 6 | 604
Lymphoid leukemia 6 | 160
Neoplasm Metastasis 6 | 168
Ovarian Neoplasms 6 | 102
Pancreatic Neoplasms 6 | 85
Polycystic ovary syndrome 6 | 360
Squamous cell carcinoma 6 | 129
Stomach cancer 6 | 30
cutaneous lupus erythematosus 6 | 1,057
interstitial cystitis 6 | 2,312
lung carcinoma 6 | 2,843
non-small cell lung carcinoma 6 | 317
ovarian neoplasm 6 | 99
pediatric high grade glioma 6 | 1,064
primary Sjogren syndrome 6 | 735
Atopic dermatitis 5 | 952
Brain Ischemia 5 | 110
Depressive disorder 5 | 409
Endometriosis 5 | 540
Heart disease 5 | 306
Kidney disease 5 | 430
Lung disease 5 | 142
Multiple Sclerosis 5 | 540
Waldenstrons macroglobulinemia 5 | 765
astrocytoma 5 | 1,146
esophageal adenocarcinoma 5 | 737
hepatocellular carcinoma 5 | 547

Tissue

Blood and immune system 44 | 16,909
Cardiovascular System 44 | 15,192
Digestive Tract 44 | 17,369
Endocrine System 44 | 18,159
Female tissues 44 | 17,400
Liver and Pancreas 44 | 16,750
Male tissues 44 | 17,142
Nervous System 44 | 16,725
Respiratory system 44 | 16,393
Skin and soft tissues 44 | 17,230
Urinary Tract 44 | 16,678

Target Family

Enzyme 12 | 4,145
Non-IDG 12 | 12,091
Kinase 11 | 634
Transcription Factor 9 | 1,400
Epigenetic 1 | 242

WikiPathways Pathway

Integrated Cancer Pathway 45 | 45
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bcl-2-binding component 3 BBC3 Tbio Non-IDG -2.02081 88.0 559
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
DNA mismatch repair protein Msh6 MSH6 Tbio Epigenetic -2.72594 572.3 479
Caspase-9 CASP9 Tchem Enzyme -3.44725 2332.0 1313
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150
Serine/threonine-protein kinase Chk2 CHEK2 Tchem Kinase -3.00304 978.7 1374
Bcl2-associated agonist of cell death BAD Tchem Non-IDG -2.08893 103.4 2565
Serine/threonine-protein kinase Chk1 CHEK1 Tchem Kinase -3.04423 1089.6 1375
Cyclic AMP-dependent transcription factor ATF-1 ATF1 Tchem Transcription Factor -1.74625 53.7 445
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.76784 6081.3 1542