Development Level

Tbio 80 | 11,651
Tchem 52 | 1,388
Tclin 16 | 612
Tdark 4 | 6,593

IMPC Phenotype

preweaning lethality, complete... 16 | 979
preweaning lethality, incomple... 8 | 499
embryonic lethality prior to t... 7 | 278
embryonic lethality prior to o... 6 | 239
abnormal embryo size 4 | 220
abnormal bone structure 3 | 187
decreased body weight 3 | 161
decreased circulating creatini... 3 | 39
decreased mean corpuscular hem... 3 | 50
female infertility 3 | 60
increased total body fat amoun... 3 | 134
male infertility 3 | 123
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased caudal vertebrae num... 2 | 53
decreased circulating glucose ... 2 | 126
decreased circulating serum al... 2 | 82
decreased lean body mass 2 | 135
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating sodium l... 2 | 71
increased mean corpuscular hem... 2 | 96
increased neutrophil cell numb... 2 | 46
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
abnormal spinal cord morpholog... 1 | 9
abnormal startle reflex 1 | 15
abnormal tooth morphology 1 | 24
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating creatine... 1 | 4
decreased circulating fructosa... 1 | 30
decreased circulating glycerol... 1 | 16
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased lactate dehydrogenas... 1 | 16
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
decreased thermal nociceptive ... 1 | 2
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating choleste... 1 | 66
increased circulating creatine... 1 | 5
increased circulating free fat... 1 | 20
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased kidney weight 1 | 6
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
mammalian phenotype 1 | 17
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
sclerocornea 1 | 2
short tibia 1 | 97
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56

Disease

Carcinoma 114 | 11,493
ovarian cancer 114 | 8,520
Cancer 92 | 2,499
osteosarcoma 92 | 7,950
glioblastoma 80 | 5,792
atypical teratoid / rhabdoid tumor 77 | 5,112
psoriasis 77 | 6,694
lung cancer 75 | 4,740
Breast cancer 73 | 3,578
medulloblastoma, large-cell 72 | 6,241
ependymoma 55 | 4,679
Kidney cancer 54 | 2,613
malignant mesothelioma 51 | 3,232
adult high grade glioma 49 | 3,801
group 3 medulloblastoma 48 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 42 | 3,291
primitive neuroectodermal tumor 41 | 3,035
invasive ductal carcinoma 40 | 2,951
Breast Neoplasms 38 | 445
Mammary Neoplasms 38 | 425
pancreatic cancer 36 | 2,398
Astrocytoma, Pilocytic 34 | 3,081
Prostatic Neoplasms 34 | 495
breast carcinoma 33 | 1,638
non-small cell lung cancer 33 | 2,890
oligodendroglioma 33 | 2,850
tuberculosis 32 | 2,010
Schizophrenia 31 | 1,160
lung adenocarcinoma 31 | 2,716
lung carcinoma 31 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,989
subependymal giant cell astrocytoma 29 | 2,287
astrocytoma 28 | 1,146
ductal carcinoma in situ 28 | 1,745
diabetes mellitus 27 | 1,728
acute quadriplegic myopathy 26 | 1,158
Autosomal recessive predisposition 25 | 1,442
juvenile dermatomyositis 25 | 1,187
Carcinoma, Hepatocellular 24 | 228
Liver carcinoma 24 | 240
Stomach Neoplasms 24 | 300
astrocytic glioma 24 | 2,597
Intellectual disability 23 | 1,016
Multiple myeloma 23 | 1,332
ulcerative colitis 23 | 1,819
Neoplasm Metastasis 22 | 168
adrenocortical carcinoma 22 | 1,428
colon cancer 22 | 1,478
dermatomyositis 22 | 966
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,955
Melanoma 21 | 711
Colorectal Neoplasms 20 | 243
Dull intelligence 20 | 645
Low intelligence 20 | 645
Mental Retardation 20 | 645
Mental deficiency 20 | 645
Poor school performance 20 | 645
Squamous cell carcinoma 20 | 129
group 4 medulloblastoma 20 | 1,855
pediatric high grade glioma 20 | 1,064
Adenoma 19 | 167
Alzheimer's disease 19 | 658
Epilepsy 19 | 792
Lung Neoplasms 19 | 232
Obesity 19 | 678
Pick disease 19 | 1,894
Short stature 19 | 531
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
pituitary cancer 19 | 1,972
Adenocarcinoma 18 | 122
Rheumatoid arthritis 18 | 1,191
Seizures 18 | 596
Vascular disease 18 | 319
cystic fibrosis 18 | 1,696
interstitial cystitis 18 | 2,312
Bipolar Disorder 17 | 666
Carcinoma, Squamous Cell 17 | 110
Pancreatic Neoplasm 17 | 85
Cognitive delay 16 | 608
Colonic Neoplasms 16 | 142
Endometrial cancer 16 | 311
Endometriosis 16 | 540
Global developmental delay 16 | 608
Liver cancer 16 | 604
Lymphoid leukemia 16 | 160
Mental and motor retardation 16 | 608
Pancreatic Neoplasms 16 | 85
nasopharyngeal carcinoma 16 | 1,058
Cell Transformation, Neoplastic 15 | 97
Hypertension 15 | 396
Hypertensive disease 15 | 292
Immune system cancer 15 | 140
Small head 15 | 374
Depressive disorder 14 | 409
Muscle hypotonia 14 | 571
Neoplastic Cell Transformation 14 | 89
Ovarian Neoplasms 14 | 102
cutaneous lupus erythematosus 14 | 1,057
ovarian neoplasm 14 | 99
Waldenstrons macroglobulinemia 13 | 765

Tissue

Nervous System 150 | 16,725
Digestive Tract 149 | 17,369
Endocrine System 149 | 18,159
Female tissues 149 | 17,400
Blood and immune system 148 | 16,909
Skin and soft tissues 148 | 17,230
Liver and Pancreas 147 | 16,750
Male tissues 147 | 17,142
Respiratory system 147 | 16,393
Urinary Tract 147 | 16,678
Cardiovascular System 146 | 15,192

Target Family

Non-IDG 47 | 12,091
Enzyme 38 | 4,145
Kinase 34 | 634
Transcription Factor 23 | 1,400
Epigenetic 7 | 242
Nuclear Receptor 2 | 48
GPCR 1 | 408

WikiPathways Pathway

Integrated Breast Cancer Pathw... 152 | 152
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610
Nuclear receptor coactivator 3 NCOA3 Tbio Epigenetic -2.64583 480.2 417
Ubiquitin carboxyl-terminal hydrolase 16 USP16 Tbio Enzyme -0.67094 5.97 248
BH3-interacting domain death agonist BID Tbio Non-IDG -1.85313 58.9 981
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Tumor necrosis factor receptor superfamily member EDAR EDAR Tbio Non-IDG -2.21203 161.3 194
Mitogen-activated protein kinase kinase kinase 13 MAP3K13 Tchem Kinase -1.97318 83.8 177
Granulins GRN Tbio Non-IDG -3.03490 1139.8 416
Protein kinase C-binding protein 1 ZMYND8 Tbio Epigenetic -1.07898 13.9 128