Development Level

Tbio 73 | 10,625
Tchem 59 | 1,890
Tclin 16 | 602
Tdark 4 | 7,003

IMPC Term

preweaning lethality, complete... 10 | 633
preweaning lethality, incomple... 7 | 260
decreased lean body mass 6 | 195
embryonic lethality prior to t... 6 | 187
abnormal tooth morphology 3 | 24
decreased body weight 3 | 174
decreased bone mineral content 3 | 157
decreased circulating creatini... 3 | 31
decreased mean corpuscular hem... 3 | 34
embryonic lethality prior to o... 3 | 148
abnormal bone structure 2 | 131
abnormal embryo size 2 | 112
abnormal maxilla morphology 2 | 16
abnormal snout morphology 2 | 18
decreased blood urea nitrogen ... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased total body fat amoun... 2 | 186
increased circulating sodium l... 2 | 71
increased mean corpuscular hem... 2 | 93
abnormal bone mineralization 1 | 55
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal eye morphology 1 | 38
abnormal forebrain development 1 | 18
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 24
abnormal iris morphology 1 | 12
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal placement of pupils 1 | 4
abnormal seminal vesicle morph... 1 | 47
abnormal skin condition 1 | 6
abnormal startle reflex 1 | 14
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating aspartat... 1 | 27
decreased circulating fructosa... 1 | 31
decreased circulating glycerol... 1 | 19
decreased circulating magnesiu... 1 | 11
decreased circulating sodium l... 1 | 18
decreased erythrocyte cell num... 1 | 43
decreased lactate dehydrogenas... 1 | 14
decreased leukocyte cell numbe... 1 | 54
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased respiratory quotient 1 | 12
decreased rib number 1 | 59
decreased thermal nociceptive ... 1 | 4
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
female infertility 1 | 34
hydrops fetalis 1 | 22
impaired glucose tolerance 1 | 52
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating LDL chol... 1 | 15
increased circulating alkaline... 1 | 119
increased circulating free fat... 1 | 17
increased circulating triglyce... 1 | 24
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased kidney weight 1 | 4
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 57
irregularly shaped pupil 1 | 7
male infertility 1 | 62
microphthalmia 1 | 15
narrow eye opening 1 | 15
persistence of hyaloid vascula... 1 | 22
small superior vagus ganglion 1 | 20
thrombocytopenia 1 | 46

Disease

ovarian cancer 111 | 8,484
osteosarcoma 91 | 7,933
Cancer 90 | 2,346
psoriasis 77 | 6,685
glioblastoma 76 | 5,572
medulloblastoma, large-cell 72 | 6,234
lung cancer 70 | 4,466
atypical teratoid / rhabdoid tumor 65 | 4,369
Breast cancer 62 | 3,094
malignant mesothelioma 49 | 3,162
Carcinoma 46 | 2,147
pediatric high grade glioma 46 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 42 | 3,289
primitive neuroectodermal tumor 41 | 3,031
invasive ductal carcinoma 40 | 2,950
Mammary Neoplasms 38 | 410
pilocytic astrocytoma 37 | 3,086
astrocytoma 33 | 1,493
non-small cell lung cancer 33 | 2,798
oligodendroglioma 33 | 2,849
ependymoma 32 | 2,514
Prostatic Neoplasms 31 | 471
lung adenocarcinoma 31 | 2,713
lung carcinoma 31 | 2,844
pancreatic cancer 31 | 2,300
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,988
subependymal giant cell astrocytoma 29 | 2,287
tuberculosis 29 | 1,557
ductal carcinoma in situ 28 | 1,745
diabetes mellitus 27 | 1,663
acute quadriplegic myopathy 26 | 1,157
ulcerative colitis 26 | 2,087
juvenile dermatomyositis 25 | 1,189
group 4 medulloblastoma 24 | 1,875
adult high grade glioma 23 | 2,148
Multiple myeloma 22 | 1,327
adrenocortical carcinoma 22 | 1,427
breast carcinoma 22 | 1,614
colon cancer 22 | 1,475
dermatomyositis 22 | 933
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,956
Liver carcinoma 21 | 217
Neoplastic Syndromes, Hereditary 21 | 48
Colorectal Neoplasms 20 | 217
group 3 medulloblastoma 20 | 2,254
Adenoma 19 | 165
Pick disease 19 | 1,893
Stomach Neoplasms 19 | 282
pituitary cancer 19 | 1,972
Alzheimer's disease 18 | 644
Lung Neoplasms 18 | 171
astrocytic glioma 18 | 2,241
cystic fibrosis 18 | 1,665
interstitial cystitis 18 | 2,299
sonic hedgehog group medulloblastoma 18 | 1,482
Rheumatoid Arthritis 17 | 1,160
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,795
Endometriosis 16 | 535
Melanoma 16 | 261
Neoplasm Metastasis 16 | 138
Peripheral Neuropathy 16 | 303
nasopharyngeal carcinoma 16 | 1,056
posterior fossa group A ependymoma 16 | 1,511
Adenocarcinoma 15 | 115
Obesity 15 | 616
Vascular disease 15 | 281
medulloblastoma 15 | 1,524
Colonic Neoplasms 14 | 126
Intellectual disability 14 | 573
Pancreatic Neoplasm 14 | 79
atypical teratoid/rhabdoid tumor 14 | 1,095
cutaneous lupus erythematosus 14 | 1,056
ovarian neoplasm 14 | 97
pancreatic carcinoma 14 | 567
Amyotrophic Lateral Sclerosis 13 | 431
IGA Glomerulonephritis 13 | 454
Kidney disease 13 | 396
Neoplastic Cell Transformation 13 | 81
Parkinson's disease 13 | 364
Squamous cell carcinoma 13 | 94
Waldenstrons macroglobulinemia 13 | 765
posterior fossa group B ependymoma 13 | 1,530
Kidney cancer 12 | 118
Mammary Neoplasms, Experimental 12 | 150
gastric cancer 12 | 430
non primary Sjogren syndrome sicca 12 | 840
non-small cell lung carcinoma 12 | 413
primary pancreatic ductal adenocarcinoma 12 | 1,271
Atopic dermatitis 11 | 944
Esophageal Neoplasms 11 | 67
Prostate cancer 11 | 172
Schizophrenia 11 | 501
esophageal adenocarcinoma 11 | 737
spina bifida 11 | 1,064
Animal Mammary Neoplasms 10 | 136
Chronic Lymphocytic Leukemia 10 | 242
Heart disease 10 | 279
Polycystic Ovary Syndrome 10 | 332
active Crohn's disease 10 | 918
acute myeloid leukemia 10 | 780

Tissue

Endocrine System 152 | 18,512
Female tissues 152 | 18,647
Nervous System 152 | 18,561
Blood and immune system 151 | 17,995
Cardiovascular System 151 | 17,958
Digestive Tract 151 | 18,473
Liver and Pancreas 151 | 18,136
Male tissues 151 | 17,969
Urinary Tract 151 | 18,444
Respiratory system 150 | 17,484
Skin and soft tissues 149 | 18,115

Target Family

Non-IDG 47 | 11,971
Enzyme 38 | 4,146
Kinase 34 | 634
Transcription Factor 23 | 1,400
Epigenetic 7 | 242
Nuclear Receptor 2 | 48
GPCR 1 | 406

WikiPathways Pathway

Integrated Breast Cancer Pathw... 152 | 152
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062