Development Level

Tchem 86 | 1,890
Tbio 64 | 10,625
Tclin 10 | 602

Collection

Eligible Kinase Proteins 5 | 134

IMPC Term

preweaning lethality, complete... 6 | 633
decreased body weight 5 | 174
increased mean corpuscular hem... 5 | 93
preweaning lethality, incomple... 4 | 260
abnormal embryo size 3 | 112
abnormal retinal pigmentation 3 | 61
decreased body length 3 | 108
decreased circulating creatini... 3 | 31
decreased total body fat amoun... 3 | 186
embryonic lethality prior to t... 3 | 187
increased circulating alkaline... 3 | 119
increased circulating choleste... 3 | 53
increased mean corpuscular vol... 3 | 91
abnormal bone mineralization 2 | 55
abnormal bone structure 2 | 131
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal lens morphology 2 | 73
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal retina morphology 2 | 100
abnormal spinal cord morpholog... 2 | 8
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 37
decreased circulating choleste... 2 | 85
decreased circulating glucose ... 2 | 121
decreased circulating glycerol... 2 | 19
decreased circulating triglyce... 2 | 83
decreased fasted circulating g... 2 | 49
decreased grip strength 2 | 123
decreased lean body mass 2 | 195
decreased lumbar vertebrae num... 2 | 62
increased circulating LDL chol... 2 | 15
increased circulating chloride... 2 | 43
increased erythrocyte cell num... 2 | 26
increased hematocrit 2 | 36
male infertility 2 | 62
abnormal behavior 1 | 226
abnormal behavioral response t... 1 | 52
abnormal eyelid aperture 1 | 3
abnormal gait 1 | 51
abnormal glucose homeostasis 1 | 5
abnormal optic disc morphology 1 | 10
abnormal respiratory quotient 1 | 9
abnormal retinal vasculature m... 1 | 15
abnormal sleep behavior 1 | 63
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
abnormal vibrissa morphology 1 | 17
absent heartbeat 1 | 6
absent seminal vesicle 1 | 2
cataract 1 | 26
decreased IgG1 level 1 | 4
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral content 1 | 157
decreased cervical vertebrae n... 1 | 12
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating fructosa... 1 | 31
decreased circulating sodium l... 1 | 18
decreased erythrocyte cell num... 1 | 43
decreased leukocyte cell numbe... 1 | 54
decreased lymphocyte cell numb... 1 | 9
decreased prepulse inhibition 1 | 52
decreased startle reflex 1 | 48
decreased threshold for audito... 1 | 32
embryonic lethality prior to o... 1 | 148
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
female infertility 1 | 34
hypoactivity 1 | 89
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating calcium ... 1 | 32
increased circulating iron lev... 1 | 25
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 20
increased grip strength 1 | 83
increased heart rate 1 | 17
increased hemoglobin content 1 | 45
increased neutrophil cell numb... 1 | 15
increased sacral vertebrae num... 1 | 62
microphthalmia 1 | 15
prolonged PQ interval 1 | 3
prolonged QRS complex duration 1 | 2
short tibia 1 | 82
shortened RR interval 1 | 19
shortened ST segment 1 | 9
small superior vagus ganglion 1 | 20
small testis 1 | 37
thrombocytopenia 1 | 46
thrombocytosis 1 | 23
vertebral fusion 1 | 23

Disease

ovarian cancer 104 | 8,492
osteosarcoma 91 | 7,933
psoriasis 81 | 6,685
medulloblastoma, large-cell 71 | 6,234
Cancer 67 | 2,346
glioblastoma 67 | 5,572
atypical teratoid / rhabdoid tumor 58 | 4,369
lung cancer 58 | 4,473
diabetes mellitus 43 | 1,663
Carcinoma 42 | 2,147
ependymoma 40 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 37 | 3,289
Breast cancer 36 | 3,099
lung carcinoma 36 | 2,844
malignant mesothelioma 35 | 3,163
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,988
invasive ductal carcinoma 34 | 2,950
pilocytic astrocytoma 34 | 3,086
subependymal giant cell astrocytoma 34 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,956
non-small cell lung cancer 32 | 2,798
astrocytoma 31 | 1,493
group 4 medulloblastoma 31 | 1,875
oligodendroglioma 31 | 2,849
primitive neuroectodermal tumor 31 | 3,031
pediatric high grade glioma 30 | 2,712
lung adenocarcinoma 28 | 2,714
ulcerative colitis 28 | 2,087
pancreatic cancer 27 | 2,300
Obesity 25 | 616
Pick disease 24 | 1,893
astrocytic glioma 24 | 2,241
group 3 medulloblastoma 23 | 2,254
Vascular disease 22 | 281
breast carcinoma 22 | 1,614
interstitial cystitis 22 | 2,299
pituitary cancer 22 | 1,972
adult high grade glioma 21 | 2,148
colon cancer 21 | 1,475
ductal carcinoma in situ 21 | 1,745
juvenile dermatomyositis 21 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,795
Rheumatoid Arthritis 20 | 1,171
adrenocortical carcinoma 20 | 1,427
acute quadriplegic myopathy 19 | 1,157
dermatomyositis 19 | 967
medulloblastoma 19 | 1,524
primary pancreatic ductal adenocarcinoma 18 | 1,271
tuberculosis 18 | 1,563
cystic fibrosis 16 | 1,670
Multiple myeloma 15 | 1,328
posterior fossa group A ependymoma 15 | 1,511
Alzheimer's disease 14 | 644
Hyperglycemia 14 | 120
Mammary Neoplasms 14 | 410
Diabetes Mellitus, Non-Insulin-Dependent 13 | 161
Intellectual disability 13 | 573
Liver carcinoma 13 | 217
Parkinson's disease 13 | 364
Renal Cell Carcinoma 13 | 199
Schizophrenia 13 | 503
Waldenstrons macroglobulinemia 13 | 765
acute myeloid leukemia 13 | 785
progressive supranuclear palsy 13 | 674
Lung Neoplasms 12 | 171
cutaneous lupus erythematosus 12 | 1,056
Metabolic syndrome X 11 | 155
aldosterone-producing adenoma 11 | 664
posterior fossa group B ependymoma 11 | 1,530
spina bifida 11 | 1,064
Atopic dermatitis 10 | 944
Down syndrome 10 | 548
Insulin Resistance 10 | 50
Polycystic Ovary Syndrome 10 | 335
Prostatic Neoplasms 10 | 471
Stomach Neoplasms 10 | 282
sonic hedgehog group medulloblastoma 10 | 1,482
Arthritis 9 | 248
Blastic phase chronic myeloid leukemia 9 | 58
Chronic Myelocytic Leukemia Accelerated Phase 9 | 59
Diabetes Mellitus, Experimental 9 | 106
Heart disease 9 | 279
Hyperinsulinism 9 | 63
Noonan Syndrome 9 | 33
active Crohn's disease 9 | 918
esophageal adenocarcinoma 9 | 737
pancreatic carcinoma 9 | 567
primary Sjogren syndrome 9 | 789
Asthma 8 | 349
Cardiomegaly 8 | 66
Cardiomyopathies 8 | 90
Epilepsy 8 | 346
Kidney disease 8 | 397
Melanoma 8 | 261
Toxic encephalopathy 8 | 131
fibroadenoma 8 | 557
gastric carcinoma 8 | 832
nasopharyngeal carcinoma 8 | 1,056
non primary Sjogren syndrome sicca 8 | 840
Myocardial Ischemia 7 | 169

Tissue

Blood and immune system 160 | 17,995
Female tissues 160 | 18,647
Liver and Pancreas 160 | 18,136
Nervous System 160 | 18,561
Digestive Tract 159 | 18,473
Endocrine System 159 | 18,512
Male tissues 159 | 17,969
Cardiovascular System 158 | 17,958
Urinary Tract 158 | 18,444
Respiratory system 157 | 17,484
Skin and soft tissues 157 | 18,115

Target Family

Kinase 81 | 634
Non-IDG 40 | 11,969
Enzyme 29 | 4,146
Transcription Factor 8 | 1,400
Transporter 2 | 473

WikiPathways Pathway

Insulin Signaling 160 | 160
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase kinase kinase kinase 5 MAP4K5 Tchem Kinase -1.76072 56.9 0
Adenylyl cyclase-associated protein 1 CAP1 Tbio Enzyme -0.87211 7.62 129
Mitogen-activated protein kinase kinase kinase 3 MAP3K3 Tchem Kinase -1.70303 53.0 162
Kinesin-like protein KIF3A KIF3A Tbio Non-IDG -2.03835 107.4 139
Insulin receptor substrate 2 IRS2 Tbio Non-IDG -2.62322 398.1 207
Protein kinase C beta type PRKCB Tchem Kinase -1.97915 83.5 530
Mitogen-activated protein kinase kinase kinase 5 MAP3K5 Tchem Kinase -2.61089 467.7 1104
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.51668 46.0 252
Mitogen-activated protein kinase kinase kinase 2 MAP3K2 Tchem Kinase -1.45286 25.5 179
Mitogen-activated protein kinase kinase kinase 10 MAP3K10 Tchem Kinase -1.13158 14.2 196