Development Level

Tbio 76 | 11,651
Tchem 73 | 1,388
Tclin 11 | 612

Collection

Kinase: IDG Consortium (Target... 5 | 125

IMPC Phenotype

preweaning lethality, complete... 14 | 979
preweaning lethality, incomple... 8 | 499
decreased body weight 6 | 161
increased mean corpuscular hem... 5 | 96
embryonic lethality prior to t... 4 | 278
abnormal embryo size 3 | 220
decreased circulating creatini... 3 | 39
decreased circulating glucose ... 3 | 126
decreased total body fat amoun... 3 | 207
decreased vertical activity 3 | 208
increased circulating choleste... 3 | 66
increased lean body mass 3 | 172
increased mean corpuscular vol... 3 | 92
increased total body fat amoun... 3 | 134
male infertility 3 | 123
abnormal bone mineralization 2 | 38
abnormal bone structure 2 | 187
abnormal coat appearance 2 | 31
abnormal lens morphology 2 | 81
abnormal retina morphology 2 | 71
decreased body length 2 | 101
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating glycerol... 2 | 16
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased prepulse inhibition 2 | 82
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
increased circulating HDL chol... 2 | 80
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased circulating chloride... 2 | 41
increased hematocrit 2 | 46
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retinal vasculature m... 1 | 27
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
absent seminal vesicle 1 | 4
cataract 1 | 92
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating fructosa... 1 | 30
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased mean platelet volume 1 | 25
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
female infertility 1 | 60
hypoactivity 1 | 132
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased heart left ventricle... 1 | 4
increased heart rate 1 | 23
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
microphthalmia 1 | 26
prolonged PQ interval 1 | 5
prolonged PR interval 1 | 15
short tibia 1 | 97
shortened RR interval 1 | 17
shortened ST segment 1 | 10
small testis 1 | 58
small uterus 1 | 3
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Carcinoma 130 | 11,493
ovarian cancer 104 | 8,520
osteosarcoma 91 | 7,950
psoriasis 81 | 6,694
medulloblastoma, large-cell 71 | 6,241
glioblastoma 70 | 5,792
Cancer 69 | 2,499
lung cancer 63 | 4,740
atypical teratoid / rhabdoid tumor 61 | 5,112
ependymoma 55 | 4,679
Kidney cancer 46 | 2,613
Breast cancer 44 | 3,578
diabetes mellitus 43 | 1,728
group 3 medulloblastoma 42 | 4,104
adult high grade glioma 39 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 37 | 3,291
malignant mesothelioma 37 | 3,232
lung carcinoma 36 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,989
invasive ductal carcinoma 34 | 2,951
subependymal giant cell astrocytoma 34 | 2,287
Astrocytoma, Pilocytic 33 | 3,081
astrocytic glioma 33 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,955
non-small cell lung cancer 32 | 2,890
oligodendroglioma 31 | 2,850
primitive neuroectodermal tumor 31 | 3,035
group 4 medulloblastoma 30 | 1,855
Schizophrenia 28 | 1,160
lung adenocarcinoma 28 | 2,716
pancreatic cancer 28 | 2,398
Obesity 25 | 678
breast carcinoma 25 | 1,638
tuberculosis 25 | 2,010
Pick disease 24 | 1,894
Vascular disease 23 | 319
astrocytoma 23 | 1,146
interstitial cystitis 22 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,962
pituitary cancer 22 | 1,972
Rheumatoid arthritis 21 | 1,191
colon cancer 21 | 1,478
ductal carcinoma in situ 21 | 1,745
juvenile dermatomyositis 21 | 1,187
adrenocortical carcinoma 20 | 1,428
ulcerative colitis 20 | 1,819
Autosomal recessive predisposition 19 | 1,442
Hyperglycemia 19 | 137
acute quadriplegic myopathy 19 | 1,158
dermatomyositis 19 | 966
Intellectual disability 18 | 1,016
cystic fibrosis 17 | 1,696
primary pancreatic ductal adenocarcinoma 17 | 1,109
Breast Neoplasms 16 | 445
Cognitive delay 16 | 608
Epilepsy 16 | 792
Global developmental delay 16 | 608
Mental and motor retardation 16 | 608
Orbital separation excessive 16 | 244
Insulin Resistance 15 | 72
Mammary Neoplasms 15 | 425
Multiple myeloma 15 | 1,332
Renal Cell Carcinoma 15 | 214
Short stature 15 | 531
active ulcerative colitis 15 | 764
Alzheimer's disease 14 | 658
Bipolar Disorder 14 | 666
Carcinoma, Hepatocellular 14 | 228
Dull intelligence 14 | 645
Liver carcinoma 14 | 240
Low intelligence 14 | 645
Lung Neoplasms 14 | 232
Mental Retardation 14 | 645
Mental deficiency 14 | 645
Parkinson's disease 14 | 392
Poor school performance 14 | 645
Seizures 14 | 596
progressive supranuclear palsy 14 | 676
Byzanthine arch palate 13 | 194
Concave bridge of nose 13 | 195
Depressed nasal bridge 13 | 195
Depressed nasal root/bridge 13 | 195
Diabetes Mellitus, Non-Insulin-Dependent 13 | 145
Downward slant of palpebral fissure 13 | 158
Hypertension 13 | 396
Liver Cirrhosis, Experimental 13 | 769
Muscle hypotonia 13 | 571
Polycystic ovary syndrome 13 | 360
Waldenstrons macroglobulinemia 13 | 765
acute myeloid leukemia 13 | 783
Diabetes Mellitus, Type 2 12 | 142
Hyperinsulinism 12 | 133
Pectus excavatum 12 | 100
cutaneous lupus erythematosus 12 | 1,057
pediatric high grade glioma 12 | 1,064
Hypoplastic mandible condyle 11 | 275
Mandibular hypoplasia 11 | 275
Micrognathism 11 | 275
aldosterone-producing adenoma 11 | 665
spina bifida 11 | 1,074

Tissue

Digestive Tract 158 | 17,369
Endocrine System 158 | 18,159
Skin and soft tissues 158 | 17,230
Female tissues 157 | 17,400
Male tissues 157 | 17,142
Blood and immune system 156 | 16,909
Liver and Pancreas 156 | 16,750
Nervous System 156 | 16,725
Urinary Tract 156 | 16,678
Cardiovascular System 155 | 15,192
Respiratory system 155 | 16,393

Target Family

Kinase 81 | 634
Non-IDG 40 | 12,091
Enzyme 29 | 4,145
Transcription Factor 8 | 1,400
Transporter 2 | 473

WikiPathways Pathway

Insulin Signaling 160 | 160
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase CBL-B CBLB Tbio Enzyme -0.82313 6.58 193
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
ATP-dependent 6-phosphofructokinase, liver type PFKL Tbio Kinase -2.07015 107.6 240
Glycogen [starch] synthase, liver GYS2 Tbio Enzyme -1.61077 38.6 69
5'-AMP-activated protein kinase catalytic subunit alpha-2 PRKAA2 Tchem Kinase -1.42705 21.1 603
Kinesin-like protein KIF3A KIF3A Tbio Non-IDG -2.06068 113.6 153
Mitogen-activated protein kinase kinase kinase 3 MAP3K3 Tchem Kinase -1.73612 54.7 183
Adenylyl cyclase-associated protein 1 CAP1 Tbio Enzyme -1.03272 8.93 160
Insulin receptor substrate 2 IRS2 Tbio Non-IDG -2.64133 414.7 227
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452